PMID- 31461866
OWN - NLM
STAT- MEDLINE
DCOM- 20201020
LR  - 20201020
IS  - 2072-6651 (Electronic)
IS  - 2072-6651 (Linking)
VI  - 11
IP  - 9
DP  - 2019 Aug 27
TI  - A Novel Magnetic Molecular Imprinted Polymer for Selective Extraction of 
      Zearalenone from Cereal Flours before Liquid Chromatography-Tandem Mass 
      Spectrometry Determination.
LID - 10.3390/toxins11090493 [doi]
LID - 493
AB  - Zearalenone (ZEN) is a nonsteroidal estrogenic mycotoxin produced by various 
      Fusarium species and commonly occurring in corn and other cereals. Even though 
      its acute toxicity is low, still the estrogenic activity of ZEN and metabolites 
      is a matter of concern. In this work, a new magnetic molecularly imprinted 
      polymer (mMIP) for the selective extraction of ZEN from cereal flours is 
      presented. The mMIP was synthesized previously using quercetin as dummy template, 
      and here we wanted to test its applicability to complex food samples. Analyte 
      determination was carried out by high-performance liquid chromatography coupled 
      to tandem mass spectrometry. The selectivity of the mMIP and the main validation 
      method parameters were assessed. In particular, even in samples as complex as 
      cereals, matrix effect was negligible. Although the mMIP showed cross-selectivity 
      towards both ZEN-related and quercetin-related compounds, nonetheless ZEN 
      recovery was > 95% for the two lower spiking levels, and the quantification limit 
      was 0.14 ng g(-1), i.e., ca. 500 times lower than the maximum limit fixed for 
      most cereals by European law. Therefore, the material, also in comparison with a 
      commercial sorbent, appears suitable for the application in food analysis, also 
      to isolate ZEN at trace levels.
FAU - Cavaliere, Chiara
AU  - Cavaliere C
AUID- ORCID: 0000-0003-1332-682X
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy.
FAU - Antonelli, Michela
AU  - Antonelli M
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy.
FAU - Cerrato, Andrea
AU  - Cerrato A
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy.
FAU - La Barbera, Giorgia
AU  - La Barbera G
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy. 
      giorgia.labarbera@uniroma1.it.
FAU - Lagana, Aldo
AU  - Lagana A
AUID- ORCID: 0000-0003-4963-3020
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy. 
      aldo.lagana@uniroma1.it.
AD  - CNR, NANOTEC - Campus Ecotekne, Universita del Salento, 73100 Lecce, Italy. 
      aldo.lagana@uniroma1.it.
FAU - Laus, Michele
AU  - Laus M
AD  - Department of Science and Technological Innovation, Universita del Piemonte 
      Orientale "A. Avogadro", 15121 Alessandria, Italy.
FAU - Piovesana, Susy
AU  - Piovesana S
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy.
FAU - Capriotti, Anna Laura
AU  - Capriotti AL
AD  - Department of Chemistry, Universita di Roma "La Sapienza", 00185 Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190827
PL  - Switzerland
TA  - Toxins (Basel)
JT  - Toxins
JID - 101530765
RN  - 0 (Magnetite Nanoparticles)
RN  - 0 (Methacrylates)
RN  - 0 (Polymers)
RN  - 0 (Pyridines)
RN  - 5W827M159J (Zearalenone)
RN  - 7BK5G69305 (ethylene dimethacrylate)
RN  - 9IKM0I5T1E (Quercetin)
RN  - I56G67XM8D (4-vinylpyridine)
SB  - IM
MH  - Chromatography, Liquid
MH  - Edible Grain/*chemistry
MH  - Flour/analysis
MH  - Food Analysis/instrumentation/*methods
MH  - Food Contamination/*analysis
MH  - Limit of Detection
MH  - Magnetic Phenomena
MH  - Magnetite Nanoparticles/chemistry
MH  - Methacrylates/chemistry
MH  - Molecular Imprinting/*methods
MH  - Polymers/*chemistry
MH  - Pyridines/chemistry
MH  - Quercetin/chemistry
MH  - Solid Phase Extraction
MH  - Tandem Mass Spectrometry
MH  - Zearalenone/*analysis
PMC - PMC6784151
OTO - NOTNLM
OT  - dispersive solid-phase extraction
OT  - dummy template
OT  - liquid chromatography-tandem mass spectrometry
OT  - magnetic molecularly imprinted polymers
OT  - sample preparation
OT  - zearalenone
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/30 06:00
MHDA- 2020/10/21 06:00
PMCR- 2019/09/01
CRDT- 2019/08/30 06:00
PHST- 2019/08/01 00:00 [received]
PHST- 2019/08/22 00:00 [revised]
PHST- 2019/08/23 00:00 [accepted]
PHST- 2019/08/30 06:00 [entrez]
PHST- 2019/08/30 06:00 [pubmed]
PHST- 2020/10/21 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - toxins11090493 [pii]
AID - toxins-11-00493 [pii]
AID - 10.3390/toxins11090493 [doi]
PST - epublish
SO  - Toxins (Basel). 2019 Aug 27;11(9):493. doi: 10.3390/toxins11090493.