PMID- 31462282
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20240117
IS  - 1532-429X (Electronic)
IS  - 1097-6647 (Print)
IS  - 1097-6647 (Linking)
VI  - 21
IP  - 1
DP  - 2019 Aug 29
TI  - Multiparametric cardiovascular magnetic resonance imaging in acute myocarditis: a 
      comparison of different measurement approaches.
PG  - 54
LID - 10.1186/s12968-019-0568-x [doi]
LID - 54
AB  - BACKGROUND: Myocardial T1 and T2 mapping are reliable diagnostic markers for the 
      detection and follow up of acute myocarditis. The aim of this study was to 
      compare the diagnostic performance of current mapping measurement approaches to 
      differentiate between myocarditis patients and healthy individuals. METHODS: 
      Fifty patients with clinically defined acute myocarditis and 30 healthy controls 
      underwent cardiovascular magnetic resonance (CMR). Myocardial T1 relaxation 
      times, T2 relaxation times, left ventricular (LV) function, T2 ratio, early 
      gadolinium enhancement ratio, and presence of late gadolinium enhancement (LGE) 
      were analysed. Native T1 and T2 relaxation times, as well as extracellular volume 
      fraction (ECV) were measured for the entire LV myocardium (global), within the 
      midventricular short axis slice (mSAX), within the midventricular septal wall 
      (ConSept), and within the remote myocardium (remote). Receiver operating 
      characteristics analysis was performed to compare diagnostic performance. 
      RESULTS: All measurement approaches revealed significantly higher native T1 and 
      T2 relaxation times as well as ECV values in patients compared to healthy 
      controls (p < 0.05 for all parameters). The global measurement approach showed 
      highest diagnostic performance regarding all mapping parameters (AUCs, native T1: 
      0.903, T2: 0.847, ECV: 0.731). Direct comparison of the different measurement 
      approaches revealed significant differences in diagnostic performance between the 
      global and the remote approach regarding T1 relaxation times and ECV (p = 0.001 
      and p = 0.002 respectively). Further, the global measurement approach revealed 
      significantly higher T1 relaxation times compared to the ConSept approach (AUCs: 
      0.903 vs. 0.783; p = 0.003) and nearly significant differences compared to the 
      mSAX approach (AUC: 0.850; p = 0.051). T2 relaxation times showed no significant 
      differences between all measurement approaches (p > 0.050 for all parameters). 
      CONCLUSIONS: Native T1 and T2 mapping allow for accurate detection of acute 
      myocarditis irrespective of the measurement approach used. Even measurements 
      performed exclusively within remote myocardium allow for reliable detection of 
      acute myocarditis, demonstrating diffuse involvement of disease despite a mostly 
      regional or patchy distribution pattern of visible pathologies. The global 
      measurement approach provides the overall best diagnostic performance in acute 
      myocarditis for both T1 and T2 mapping.
FAU - Dabir, Darius
AU  - Dabir D
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Vollbrecht, Thomas M
AU  - Vollbrecht TM
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Luetkens, Julian A
AU  - Luetkens JA
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Kuetting, Daniel L R
AU  - Kuetting DLR
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Isaak, Alexander
AU  - Isaak A
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Feisst, Andreas
AU  - Feisst A
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Fimmers, Rolf
AU  - Fimmers R
AD  - Department of Medical Biometry, Computer Science, and Epidemiology (IMBIE), 
      University of Bonn, Bonn, Germany.
FAU - Sprinkart, Alois M
AU  - Sprinkart AM
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Schild, Hans H
AU  - Schild HH
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany.
FAU - Thomas, Daniel
AU  - Thomas D
AD  - Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, 
      Germany. daniel.thomas@ukb.uni-bonn.de.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20190829
PL  - England
TA  - J Cardiovasc Magn Reson
JT  - Journal of cardiovascular magnetic resonance : official journal of the Society 
      for Cardiovascular Magnetic Resonance
JID - 9815616
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Case-Control Studies
MH  - Contrast Media/administration & dosage
MH  - Female
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnostic imaging/pathology
MH  - Myocardium/*pathology
MH  - Organometallic Compounds/administration & dosage
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Young Adult
PMC - PMC6714458
OTO - NOTNLM
OT  - Accuracy
OT  - ECV
OT  - Mapping
OT  - Measurement approach
OT  - Myocarditis
COIS- The authors declare that they have no competing interests.
EDAT- 2019/08/30 06:00
MHDA- 2020/05/06 06:00
PMCR- 2019/08/29
CRDT- 2019/08/30 06:00
PHST- 2019/03/11 00:00 [received]
PHST- 2019/07/23 00:00 [accepted]
PHST- 2019/08/30 06:00 [entrez]
PHST- 2019/08/30 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/08/29 00:00 [pmc-release]
AID - S1097-6647(23)00227-2 [pii]
AID - 568 [pii]
AID - 10.1186/s12968-019-0568-x [doi]
PST - epublish
SO  - J Cardiovasc Magn Reson. 2019 Aug 29;21(1):54. doi: 10.1186/s12968-019-0568-x.