PMID- 31464233
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200210
IS  - 1319-2442 (Print)
IS  - 1319-2442 (Linking)
VI  - 30
IP  - 4
DP  - 2019 Jul-Aug
TI  - Early and late effects of therapeutic plasma exchange in patients with systemic 
      lupus erythematosus and antineutrophil cytoplasmic antibody-associated 
      vasculitis: A single-center experience.
PG  - 775-780
LID - 10.4103/1319-2442.265452 [doi]
AB  - Therapeutic plasma exchanges (TPE) is considered as one of the treatment 
      modalities that is used in systemic autoimmune diseases. This study aimed to 
      describe the early and late effect of TPE in patients with systemic lupus 
      erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis 
      (AAV) presented with acute kidney injury (AKI). Retrospective study comprised 
      patients with SLE and AAV with AKI seen between January 2000 and June 2014 at 
      King Faisal Specialist Hospital and Research Center in Riyadh. All patients 
      underwent TPE. Retrospectively, all patients were assessed for early and late 
      renal outcome at 12- month and 24-month intervals. Renal outcome was assessed 
      according to serum creatinine level, glomerular filtration rate, active urine 
      sediment, and proteinuria. P <0.05 was considered significant. A total of 68 
      patients were included, 58 patients (51 females) had SLE and 10 patients (7 
      females) had AAV completed TPE. All patients had active disease and had AKI. At 
      the first 12 months, 18 patients (17 SLE and 1 AAV) showed complete response and 
      14 patients had partial response while 22 patients did not show therapeutic 
      benefit. The nonresponders (22 patients) entered the late assessment interval (24 
      months) without any therapeutic response. Statistically, there was no significant 
      difference between the patient's response to TPE at the first and second 
      assessment intervals and the baseline serum creatinine level. TPE might be an 
      alternative rescue treatment in lupus nephritis with AKI.
FAU - Al Hamzi, Hanan A
AU  - Al Hamzi HA
AD  - Department of Medicine, Prince Mohammed Bin Abdulaziz Hospital, Riyadh, Saudi 
      Arabia.
FAU - Al-Mayouf, Sulaiman M
AU  - Al-Mayouf SM
AD  - Department of Pediatric Rheumatology, King Faisal Specialist Hospital and 
      Research Center, Riyadh, Saudi Arabia.
FAU - Al Shaikh, Ahmad A
AU  - Al Shaikh AA
AD  - Adult Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, 
      Saudi Arabia.
FAU - Al-Sheikh, Haifa A
AU  - Al-Sheikh HA
AD  - Adult Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, 
      Saudi Arabia.
FAU - Alshomar, Ahmad A
AU  - Alshomar AA
AD  - Adult Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, 
      Saudi Arabia.
FAU - Al Humaidan, Hind A
AU  - Al Humaidan HA
AD  - Blood Bank and Transfusion Services; Pathology and Laboratory Medicine, King 
      Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
FAU - Al Dalaan, Abdullah N
AU  - Al Dalaan AN
AD  - Adult Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, 
      Saudi Arabia.
FAU - Al Saleh, Salman S
AU  - Al Saleh SS
AD  - Adult Rheumatology, King Faisal Specialist Hospital and Research Center, Riyadh, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi J Kidney Dis Transpl
JT  - Saudi journal of kidney diseases and transplantation : an official publication of 
      the Saudi Center for Organ Transplantation, Saudi Arabia
JID - 9436968
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Biomarkers)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Kidney Injury/blood/diagnosis/immunology/*therapy
MH  - Adult
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/blood/diagnosis/immunology/*therapy
MH  - Antibodies, Antineutrophil Cytoplasmic/blood
MH  - Biomarkers/blood
MH  - Creatinine/blood
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Lupus Erythematosus, Systemic/blood/diagnosis/immunology/*therapy
MH  - Male
MH  - Middle Aged
MH  - *Plasma Exchange/adverse effects
MH  - Proteinuria/blood/immunology/therapy
MH  - Retrospective Studies
MH  - Saudi Arabia
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2019/08/30 06:00
MHDA- 2020/02/11 06:00
CRDT- 2019/08/30 06:00
PHST- 2019/08/30 06:00 [entrez]
PHST- 2019/08/30 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
AID - SaudiJKidneyDisTranspl_2019_30_4_775_265452 [pii]
AID - 10.4103/1319-2442.265452 [doi]
PST - ppublish
SO  - Saudi J Kidney Dis Transpl. 2019 Jul-Aug;30(4):775-780. doi: 
      10.4103/1319-2442.265452.