PMID- 31464408
OWN - NLM
STAT- MEDLINE
DCOM- 20200211
LR  - 20200211
IS  - 1440-6047 (Electronic)
IS  - 0964-7058 (Linking)
VI  - 28
IP  - 3
DP  - 2019
TI  - Relationship between retinol and risk of diabetic retinopathy: a case-control 
      study.
PG  - 607-613
LID - 10.6133/apjcn.201909_28(3).0021 [doi]
AB  - BACKGROUND AND OBJECTIVES: The aim of the present study was to evaluate the 
      relationship between retinol and risk of diabetic retinopathy in Chinese adults. 
      METHODS AND STUDY DESIGN: Eighty-six subjects with type 2 diabetes mellitus 
      (T2DM) and 40 healthy subjects (healthy comparison group, HCG) were recruited in 
      Beijing Luhe Hospital. Of the 86 T2DM subjects, 43 subjects were diagnosed with 
      diabetic retinopathy (DRG), and 43 subjects had no retinopathy (DNRG). RESULTS: 
      Dietary intake of retinol (p<0.001) and retinol equivalent (p<0.05) was 
      significantly higher but serum retinol and (p<0.001) retinol binding protein 4 
      (RBP4) (p<0.05) were significantly lower in DNRG compared with HCG. Dietary 
      intake of retinol (p<0.05) and retinol equivalent (p<0.05) was significantly 
      lower, and serum retinol and (p<0.01) retinol binding protein 4 (RBP4) (p<0.01) 
      were significantly higher in DRG compared with DNRG. In T2DM subjects, per 100 
      mug/day higher dietary retinol intake was associated with 17% lower risk of 
      diabetic retinopathy (odds ratio (OR), 0.83; 95% CI, 0.70 to 0.98; p=0.032), and 
      after adjusting for potential confounding factors, the OR was 0.82 (95% CI, 0.69 
      to 0.99; p=0.036); per 100 mug/day higher in dietary retinol equivalent intake was 
      associated with 12% lower risk of diabetic retinopathy (OR, 0.88; 95% CI, 0.79 to 
      0.97; p=0.010), and after adjusting for potential confounding factors, the OR was 
      0.88 (95% CI, 0.79 to 0.98; p=0.025). CONCLUSIONS: Higher dietary intake of 
      retinol or retinol equivalent is associated with lower risk of diabetic 
      retinopathy.
FAU - Zhang, Chunmei
AU  - Zhang C
AD  - Beijing Luhe Hospital, Capital Medical University, China.
FAU - Li, Kelei
AU  - Li K
AD  - Institute of Nutrition and Health, Qingdao University, Qingdao, China.
FAU - Zhang, Jiayu
AU  - Zhang J
AD  - Beijing Luhe Hospital, Capital Medical University, China.
FAU - Kuang, Xiaotong
AU  - Kuang X
AD  - Institute of Nutrition and Health, Qingdao University, Qingdao, China.
FAU - Liu, Chunxiao
AU  - Liu C
AD  - Institute of Nutrition and Health, Qingdao University, Qingdao, China.
FAU - Deng, Qingxue
AU  - Deng Q
AD  - Institute of Nutrition and Health, Qingdao University, Qingdao, China.
FAU - Li, Duo
AU  - Li D
AD  - Institute of Nutrition and Health, Qingdao University, Qingdao, China. 
      duoli@qdu.edu.cn; duoli@zju.edu.cn.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
RN  - 0 (Blood Glucose)
RN  - 11103-57-4 (Vitamin A)
RN  - 36-88-4 (Carotenoids)
SB  - IM
MH  - Aged
MH  - Blood Glucose
MH  - Carotenoids
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Retinopathy/*prevention & control
MH  - Diet/standards
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nutritional Status
MH  - Odds Ratio
MH  - Risk Factors
MH  - Vitamin A/*administration & dosage/*pharmacology
EDAT- 2019/08/30 06:00
MHDA- 2020/02/12 06:00
CRDT- 2019/08/30 06:00
PHST- 2019/08/30 06:00 [entrez]
PHST- 2019/08/30 06:00 [pubmed]
PHST- 2020/02/12 06:00 [medline]
AID - 10.6133/apjcn.201909_28(3).0021 [doi]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 2019;28(3):607-613. doi: 10.6133/apjcn.201909_28(3).0021.