PMID- 31465603
OWN - NLM
STAT- MEDLINE
DCOM- 20210624
LR  - 20210624
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 27
IP  - 2
DP  - 2020 Feb
TI  - A population-based epidemiological study of neuromyelitis optica spectrum 
      disorder in Hungary.
PG  - 308-317
LID - 10.1111/ene.14079 [doi]
AB  - BACKGROUND AND PURPOSE: The goal of this study was to determine the prevalence 
      and incidence of neuromyelitis optica spectrum disorder (NMOSD) in Hungary based 
      on the 2015 International Panel of NMO Diagnosis (IPND) criteria. METHODS: A 
      retrospective population-based cohort study was conducted of 6.4 million 
      Hungarians (age >/= 16 years) between 1 January 2006 and 31 December 2016. Possible 
      NMOSD patients were selected via multistage re-evaluation from multiple sources. 
      Crude and sex- and serostatus-specific prevalence (per 100 000 persons) and 
      incidence rates (per 1 000 000 person-years) from 2006 to 2015 were estimated and 
      age-adjusted rates were determined. RESULTS: Of 2262 study candidates, 154 NMOSD 
      patients (age >/= 16 years) with onset until 31 December 2016 were identified based 
      on 2015 IPND criteria. The prevalence analysis on 1 January 2016 included 123 
      NMOSD living cases, resulting in a prevalence of 1.91 [95% confidence interval 
      (CI) 1.52-2.28] per 100 000 persons. The 101 incident cases emerging from the 
      observed 76 394 288 person-years provided an incidence rate of 1.32 (95% CI 
      1.08-1.61) per 1 000 000 person-years. Age-adjusted prevalence was 1.87 (95% CI 
      1.56-2.23) per 100 000 persons and incidence was 1.20 (95% CI 0.98-1.46) per 
      1 000 000 person-years. CONCLUSIONS: In this first report of a large 
      population-based epidemiological study from an Eastern European Caucasian 
      population using robust case validation, a greater prevalence and incidence of 
      NMOSD was found compared to previous large studies in Caucasian populations.
CI  - (c) 2019 European Academy of Neurology.
FAU - Papp, V
AU  - Papp V
AD  - Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Iljicsov, A
AU  - Iljicsov A
AD  - Department of Neurology, Semmelweis University, Budapest, Hungary.
FAU - Rajda, C
AU  - Rajda C
AD  - Department of Neurology, University of Szeged, Szeged, Hungary.
FAU - Magyari, M
AU  - Magyari M
AD  - Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen, Denmark.
FAU - Koch-Henriksen, N
AU  - Koch-Henriksen N
AD  - Danish Multiple Sclerosis Center, Rigshospitalet, Copenhagen, Denmark.
AD  - Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Petersen, T
AU  - Petersen T
AD  - Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Jakab, G
AU  - Jakab G
AD  - Department of Neurology, Uzsoki Teaching Hospital, Budapest, Hungary.
FAU - Deme, I
AU  - Deme I
AD  - Department of Neurology, Somogy County Kaposi Mor University Teaching Hospital, 
      Kaposvar, Hungary.
FAU - Nagy, F
AU  - Nagy F
AD  - Department of Neurology, Somogy County Kaposi Mor University Teaching Hospital, 
      Kaposvar, Hungary.
FAU - Imre, P
AU  - Imre P
AD  - Department of Neurology, Csolnoky Ferenc County University Teaching Hospital, 
      Veszprem, Hungary.
FAU - Lohner, Z
AU  - Lohner Z
AD  - Department of Neurology, National Healthcare Services Center, Budapest, Hungary.
FAU - Kovacs, K
AU  - Kovacs K
AD  - Department of Neurology, Peterfy Hospital, Budapest, Hungary.
FAU - Birkas, A J
AU  - Birkas AJ
AD  - Department of Neurology, National Institute of Clinical Neurosciences, Budapest, 
      Hungary.
FAU - Koves, A
AU  - Koves A
AD  - Department of Neurology, Bajcsy-Zsilinszky Hospital and Outpatient Clinic, 
      Budapest, Hungary.
FAU - Rum, G
AU  - Rum G
AD  - Department of Neurology, Aladar Petz County Teaching Hospital, Gyor, Hungary.
FAU - Nagy, Z
AU  - Nagy Z
AD  - Department of Neurology, Markusovszky University Teaching Hospital, Szombathely, 
      Hungary.
FAU - Kerenyi, L
AU  - Kerenyi L
AD  - Department of Neurology, Fejer County Szent Gyorgy University Teaching Hospital, 
      Szekesfehervar, Hungary.
FAU - Vecsei, L
AU  - Vecsei L
AD  - Department of Neurology, University of Szeged, Szeged, Hungary.
AD  - MTA-SZTE Neuroscience Research Group of the Hungarian Academy of Sciences, 
      Szeged, Hungary.
FAU - Bencsik, K
AU  - Bencsik K
AD  - Department of Neurology, University of Szeged, Szeged, Hungary.
FAU - Jobbagy, Z
AU  - Jobbagy Z
AD  - Department of Neurology, Bacs-Kiskun County Hospital, Kecskemet, Hungary.
FAU - Dioszeghy, P
AU  - Dioszeghy P
AD  - Department of Neurology, Andras Josa Teaching Hospital, Nyiregyhaza, Hungary.
FAU - Horvath, L
AU  - Horvath L
AD  - Department of Neurology, Borsod-Abauj-Zemplen County Hospital and University 
      Teaching Hospital, Miskolc, Hungary.
FAU - Galantai, G
AU  - Galantai G
AD  - Department of Neurology, Odon Javorszky Hospital, Vac, Hungary.
FAU - Kasza, J
AU  - Kasza J
AD  - Department of Neurology, Zala County Hospital, Zalaegerszeg, Hungary.
FAU - Molnar, G
AU  - Molnar G
AD  - Department of Neurology, Balassa Janos Hospital of County Tolna, Szekszard, 
      Hungary.
FAU - Simo, M
AU  - Simo M
AD  - Department of Neurology, Semmelweis University, Budapest, Hungary.
FAU - Satori, M
AU  - Satori M
AD  - Department of Neurology, Vaszary Kolos Hospital, Esztergom, Hungary.
FAU - Rozsa, C
AU  - Rozsa C
AD  - Department of Neurology, Jahn Ferenc Hospital, Budapest, Hungary.
FAU - Acs, P
AU  - Acs P
AD  - Department of Neurology, University of Pecs, Pecs, Hungary.
FAU - Berki, T
AU  - Berki T
AD  - Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary.
FAU - Lovas, G
AU  - Lovas G
AD  - Department of Neurology, Jahn Ferenc Hospital, Budapest, Hungary.
FAU - Komoly, S
AU  - Komoly S
AD  - Department of Neurology, University of Pecs, Pecs, Hungary.
FAU - Illes, Z
AU  - Illes Z
AUID- ORCID: 0000-0001-9655-0450
AD  - Department of Neurology, Odense University Hospital, Odense, Denmark.
AD  - Institute of Clinical Research, BRIDGE, University of Southern Denmark, Odense, 
      Denmark.
LA  - eng
GR  - GINOP-2.3.2-15-2016-00039/Economic Development and Innovation Operational 
      Programme/International
GR  - R431 - A29805/Danish MS Society/International
GR  - R458 - A31859/Danish MS Society/International
GR  - grant no. 1591 8355/Graduate School of Health, Aarhus University/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190930
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Aquaporin 4)
SB  - IM
MH  - Adolescent
MH  - Aquaporin 4
MH  - Cohort Studies
MH  - Humans
MH  - Hungary/epidemiology
MH  - Incidence
MH  - *Neuromyelitis Optica/epidemiology
MH  - Retrospective Studies
OTO - NOTNLM
OT  - IPND
OT  - AQP4
OT  - incidence
OT  - neuromyelitis optica
OT  - population-based
OT  - prevalence
EDAT- 2019/08/30 06:00
MHDA- 2021/06/25 06:00
CRDT- 2019/08/30 06:00
PHST- 2019/04/10 00:00 [received]
PHST- 2019/08/21 00:00 [accepted]
PHST- 2019/08/30 06:00 [pubmed]
PHST- 2021/06/25 06:00 [medline]
PHST- 2019/08/30 06:00 [entrez]
AID - 10.1111/ene.14079 [doi]
PST - ppublish
SO  - Eur J Neurol. 2020 Feb;27(2):308-317. doi: 10.1111/ene.14079. Epub 2019 Sep 30.