PMID- 31465625 OWN - NLM STAT- MEDLINE DCOM- 20201201 LR - 20201201 IS - 1520-7560 (Electronic) IS - 1520-7552 (Linking) VI - 36 IP - 1 DP - 2020 Jan TI - Probiotics for the treatment of type 2 diabetes: A review of randomized controlled trials. PG - e3213 LID - 10.1002/dmrr.3213 [doi] AB - With the increasing prevalence of type 2 diabetes mellitus (T2DM), there is increased interest in probiotic supplementation for improving glycaemic control. This review evaluates nine randomized controlled trials that tested the effects of probiotics on glycaemic outcomes including fasting plasma glucose, fasting plasma insulin, haemoglobin A1c, and homeostatic model assessment of insulin resistance among adults with T2DM. Based on the evidence reviewed, multistrain probiotics that contain seven million to 100 billion colony forming units of Lactobacillus acidophilus, Streptococcus thermophilus, Lactobacillus bulgaricus, and/or Bifidobacterium lactis administered for 6 to 12 weeks may be efficacious for improving glycaemic control in adults with T2DM. Further research is needed to understand the role of the gut microbiota and the probiotic dose, medium, and duration of exposure that is most effective for disease management. CI - (c) 2019 John Wiley & Sons, Ltd. FAU - Tiderencel, Kelly A AU - Tiderencel KA AUID- ORCID: 0000-0002-5580-0377 AD - Department of Clinical and Preventive Nutrition Sciences, School of Health Professions, Rutgers University, Newark, New Jersey. FAU - Hutcheon, Deborah A AU - Hutcheon DA AD - Department of Clinical and Preventive Nutrition Sciences, School of Health Professions, Rutgers University, Newark, New Jersey. FAU - Ziegler, Jane AU - Ziegler J AD - Department of Clinical and Preventive Nutrition Sciences, School of Health Professions, Rutgers University, Newark, New Jersey. LA - eng PT - Journal Article PT - Review DEP - 20190912 PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 SB - IM MH - Diabetes Mellitus, Type 2/*diet therapy/prevention & control MH - *Dietary Supplements MH - Humans MH - Probiotics/*administration & dosage OTO - NOTNLM OT - diabetes mellitus OT - gastrointestinal microbiome OT - insulin resistance OT - metabolism OT - probiotics EDAT- 2019/08/30 06:00 MHDA- 2020/12/02 06:00 CRDT- 2019/08/30 06:00 PHST- 2018/08/03 00:00 [received] PHST- 2019/07/26 00:00 [revised] PHST- 2019/08/19 00:00 [accepted] PHST- 2019/08/30 06:00 [pubmed] PHST- 2020/12/02 06:00 [medline] PHST- 2019/08/30 06:00 [entrez] AID - 10.1002/dmrr.3213 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2020 Jan;36(1):e3213. doi: 10.1002/dmrr.3213. Epub 2019 Sep 12.