PMID- 31465978
OWN - NLM
STAT- MEDLINE
DCOM- 20200505
LR  - 20200505
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 182
DP  - 2019 Dec
TI  - Numerical analysis of aortic hemodynamics under the support of venoarterial 
      extracorporeal membrane oxygenation and intra-aortic balloon pump.
PG  - 105041
LID - S0169-2607(19)30966-6 [pii]
LID - 10.1016/j.cmpb.2019.105041 [doi]
AB  - BACKGROUND AND OBJECTIVE: A gap still exists in the hemodynamic effect of 
      intra-aortic balloon pump (IABP), venoarterial extracorporeal membrane 
      oxygenation (VA-ECMO), and VA-ECMO plus IABP on the blood perfusion of the 
      coronary artery, brain, and lower limb; the relation between heart flow and ECMO 
      flow; and the wall stress of vessels. METHODS: A finite-element model of the 
      aorta, ECMO, and IABP was proposed to calculate the mechanical response via 
      fluid-structure interaction. Heart failure (HF), IABP, ECMO, and ECMO plus IABP 
      were utilized to study the effect of support models. RESULTS: For the pressure 
      curve, VA-ECMO weakened the dicrotic notch of pressure compared with HF and the 
      pulsatile index (0.494 vs. 0.706 vs. 0.471 vs. 0.613). IABP, ECMO, and ECMO plus 
      IABP increased the perfusion of the coronary, brain, and renal artery compared 
      with HF. However, ECMO and ECMO plus IABP clearly reduced the blood flow of the 
      left arteria femoralis compared to that of the right arteria femoralis (ECMO: 
      194.04 vs. 730.80 mL/min; ECMO plus IABP: 342.15 vs. 947.22 mL/min). In addition, 
      the flow of ECMO accessed the renal artery more than the left ventricular flow. 
      Greater ventricular flow perfused to the renal artery at a diastolic period for 
      ECMO plus IABP, especially at the time points of 2.192 s and 2.304 s. Compared to 
      the velocity distribution with ECMO, the flow of the right arteria femoralis was 
      increased in the process of IABP-on. According to these four cases, the stress of 
      the vascular wall was increased for ECMO support at the systolic period. The peak 
      wall stress of ECMO is increased by 20% at 1.68 s. CONCLUSIONS: ECMO plus IABP is 
      more conducive to the blood supply than other cases from the result of numerical 
      simulation. The location of blood intersection was generated in the region of the 
      renal artery, which is estimated carefully.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Gu, Kaiyun
AU  - Gu K
AD  - Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 
      100191, China.
FAU - Guan, Zhiyuan
AU  - Guan Z
AD  - Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 
      100191, China.
FAU - Lin, Xuanqi
AU  - Lin X
AD  - College of Life Science and Bioengineering, Beijing University of Technology, 100 
      Pingleyuan, Chaoyang District, Beijing 200120, China.
FAU - Feng, Yunzhen
AU  - Feng Y
AD  - Shanghai East Hospital, Tongji University, 150 Jimo Rd., Pudong District, 
      Shanghai 100124, China.
FAU - Feng, Jieli
AU  - Feng J
AD  - Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 
      100191, China.
FAU - Yang, Yujie
AU  - Yang Y
AD  - Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 
      100191, China.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 
      100191, China. Electronic address: zhangzhe@bjmu.edu.cn.
FAU - Chang, Yu
AU  - Chang Y
AD  - College of Life Science and Bioengineering, Beijing University of Technology, 100 
      Pingleyuan, Chaoyang District, Beijing 200120, China. Electronic address: 
      bme@bjut.edu.cn.
FAU - Ling, Yunpeng
AU  - Ling Y
AD  - Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing 
      100191, China.
FAU - Wan, Feng
AU  - Wan F
AD  - Shanghai East Hospital, Tongji University, 150 Jimo Rd., Pudong District, 
      Shanghai 100124, China.
LA  - eng
PT  - Journal Article
DEP - 20190819
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
SB  - IM
MH  - Aorta/*physiology
MH  - *Extracorporeal Membrane Oxygenation
MH  - Finite Element Analysis
MH  - *Hemodynamics
MH  - Humans
MH  - Intra-Aortic Balloon Pumping/*instrumentation
OTO - NOTNLM
OT  - Fluid-structure interaction
OT  - Hemodynamics
OT  - Intra-aortic balloon pump
OT  - Venoarterial extracorporeal membrane oxygenation
EDAT- 2019/08/30 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/08/30 06:00
PHST- 2019/06/20 00:00 [received]
PHST- 2019/08/04 00:00 [revised]
PHST- 2019/08/18 00:00 [accepted]
PHST- 2019/08/30 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/08/30 06:00 [entrez]
AID - S0169-2607(19)30966-6 [pii]
AID - 10.1016/j.cmpb.2019.105041 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2019 Dec;182:105041. doi: 
      10.1016/j.cmpb.2019.105041. Epub 2019 Aug 19.