PMID- 31466350
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20211006
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 11
IP  - 9
DP  - 2019 Aug 28
TI  - Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes.
LID - 10.3390/nu11092022 [doi]
LID - 2022
AB  - Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free 
      fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. 
      The exact mechanisms by which the plasma FFA profile of subjects with T2DM 
      changes is unclear, but it is thought that dietary fats and changes to lipid 
      metabolism are likely to contribute. Therefore, establishing the changes in 
      concentrations of specific FFAs in an individual's plasma is important. Each type 
      of FFA has different effects on physiological processes, including the regulation 
      of lipolysis and lipogenesis in adipose tissue, inflammation, endocrine 
      signalling and the composition and properties of cellular membranes. Alterations 
      in such processes due to altered plasma FFA concentrations/profiles can 
      potentially result in the development of insulin resistance and coagulatory 
      defects. Finally, fibrates and statins, lipid-regulating drugs prescribed to 
      subjects with T2DM, are also thought to exert part of their beneficial effects by 
      impacting on plasma FFA concentrations. Thus, it is also interesting to consider 
      their effects on the concentration of FFAs in plasma. Collectively, we review how 
      FFAs are altered in T2DM and explore the likely downstream physiological and 
      pathological implications of such changes.
FAU - I S Sobczak, Amelie
AU  - I S Sobczak A
AD  - School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK.
FAU - A Blindauer, Claudia
AU  - A Blindauer C
AD  - Department of Chemistry, University of Warwick, Coventry CV4 7EQ, UK. 
      c.blindauer@warwick.ac.uk.
FAU - J Stewart, Alan
AU  - J Stewart A
AUID- ORCID: 0000-0003-4580-1840
AD  - School of Medicine, University of St Andrews, St Andrews KY16 9TF, UK. 
      ajs21@st-andrews.ac.uk.
LA  - eng
GR  - FS/15/42/31556/BHF_/British Heart Foundation/United Kingdom
GR  - PG/15/9/31270/BHF_/British Heart Foundation/United Kingdom
GR  - FS/15/42/3155/BHF_/British Heart Foundation/United Kingdom
GR  - RPG-2017-214/Leverhulme Trust/
PT  - Journal Article
PT  - Review
DEP - 20190828
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Fatty Acids, Nonesterified)
RN  - 0 (Fibric Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy/epidemiology/physiopathology
MH  - Dyslipidemias/*blood/drug therapy/epidemiology/physiopathology
MH  - Fatty Acids, Nonesterified/*blood
MH  - Fibric Acids/therapeutic use
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use
MH  - *Lipid Metabolism/drug effects
MH  - Treatment Outcome
PMC - PMC6770316
OTO - NOTNLM
OT  - cardiovascular disease
OT  - fibrates
OT  - free fatty acids
OT  - lipidomics
OT  - metabolism
OT  - statins
OT  - type-2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/31 06:00
MHDA- 2020/02/11 06:00
PMCR- 2019/09/01
CRDT- 2019/08/31 06:00
PHST- 2019/08/02 00:00 [received]
PHST- 2019/08/22 00:00 [revised]
PHST- 2019/08/24 00:00 [accepted]
PHST- 2019/08/31 06:00 [entrez]
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/09/01 00:00 [pmc-release]
AID - nu11092022 [pii]
AID - nutrients-11-02022 [pii]
AID - 10.3390/nu11092022 [doi]
PST - epublish
SO  - Nutrients. 2019 Aug 28;11(9):2022. doi: 10.3390/nu11092022.