PMID- 31466535
OWN - NLM
STAT- MEDLINE
DCOM- 20200618
LR  - 20210110
IS  - 1559-6834 (Electronic)
IS  - 0899-823X (Print)
IS  - 0899-823X (Linking)
VI  - 40
IP  - 11
DP  - 2019 Nov
TI  - Guideline implementation is effective at reducing proton pump inhibitor use in 
      hematology-oncology units: A multidisciplinary intervention for reducing 
      Clostridioides difficile risk.
PG  - 1294-1296
LID - 10.1017/ice.2019.238 [doi]
AB  - We implemented a guideline for appropriate acid suppressant use in 
      hematology-oncology patients. This intervention resulted in a sustained reduction 
      in proton pump inhibitor (PPI) use without an increase in rates of 
      gastrointestinal bleeding. Practice guidelines are effective in reducing PPI use, 
      which is associated with risk of Clostridioides difficile infection.
FAU - Ziegler, Matthew J
AU  - Ziegler MJ
AUID- ORCID: 0000-0002-5723-3927
AD  - Division of Infectious Diseases, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Freyer, Craig
AU  - Freyer C
AD  - Department of Pharmacy Services, Hospital of the University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Landsburg, Daniel
AU  - Landsburg D
AD  - Division of Hematology and Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Pegues, David
AU  - Pegues D
AD  - Division of Infectious Diseases, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Department of Healthcare Epidemiology, Infection Prevention and Control, Hospital 
      of the University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Bilker, Warren
AU  - Bilker W
AD  - Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
FAU - Hirsh, Rebecca
AU  - Hirsh R
AD  - Division of Hematology and Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Kucharczuk, Colleen
AU  - Kucharczuk C
AD  - Division of Hematology and Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Gilmar, Cheryl
AU  - Gilmar C
AD  - Department of Healthcare Epidemiology, Infection Prevention and Control, Hospital 
      of the University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Gorman, Theresa
AU  - Gorman T
AD  - Division of Hematology and Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Palmer, Melissa
AU  - Palmer M
AD  - Division of Hematology and Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Harker, Christina
AU  - Harker C
AD  - Division of Hematology and Oncology, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Lightheart, Erin
AU  - Lightheart E
AD  - Center for Clinical Effectiveness and Quality Improvement, Hospital of the 
      University of Pennsylvania, Philadelphia, Pennsylvania.
FAU - Han, Jennifer H
AU  - Han JH
AD  - Division of Infectious Diseases, Department of Medicine, Perelman School of 
      Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Department of Healthcare Epidemiology, Infection Prevention and Control, Hospital 
      of the University of Pennsylvania, Philadelphia, Pennsylvania.
AD  - Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 
      Philadelphia, Pennsylvania.
LA  - eng
GR  - U54 CK000485/CK/NCEZID CDC HHS/United States
GR  - U54CK000485/ACL/ACL HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20190830
PL  - United States
TA  - Infect Control Hosp Epidemiol
JT  - Infection control and hospital epidemiology
JID - 8804099
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Clostridium Infections/epidemiology/*prevention & control
MH  - Gastrointestinal Hemorrhage/epidemiology/*prevention & control
MH  - Hematology/standards
MH  - Hospital Units
MH  - Humans
MH  - Pennsylvania
MH  - *Practice Guidelines as Topic
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Regression Analysis
MH  - Risk Factors
MH  - Tertiary Care Centers
PMC - PMC6893867
MID - NIHMS1060728
COIS- Potential conflicts of interest: All authors report no conflicts of interest 
      relevant to this study.
EDAT- 2019/08/31 06:00
MHDA- 2020/06/19 06:00
PMCR- 2020/11/01
CRDT- 2019/08/31 06:00
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2020/06/19 06:00 [medline]
PHST- 2019/08/31 06:00 [entrez]
PHST- 2020/11/01 00:00 [pmc-release]
AID - S0899823X19002381 [pii]
AID - 10.1017/ice.2019.238 [doi]
PST - ppublish
SO  - Infect Control Hosp Epidemiol. 2019 Nov;40(11):1294-1296. doi: 
      10.1017/ice.2019.238. Epub 2019 Aug 30.