PMID- 31466815
OWN - NLM
STAT- MEDLINE
DCOM- 20200916
LR  - 20200916
IS  - 1531-5037 (Electronic)
IS  - 0022-3468 (Linking)
VI  - 55
IP  - 3
DP  - 2020 Mar
TI  - Risk factors and associated outcomes of early acute kidney injury in pediatric 
      liver transplant recipients: A retrospective study.
PG  - 446-450
LID - S0022-3468(19)30507-X [pii]
LID - 10.1016/j.jpedsurg.2019.07.019 [doi]
AB  - BACKGROUND: Acute kidney injury (AKI) may contribute to high mortality rates 
      after liver transplantation. Few studies have investigated AKI in pediatric liver 
      transplantation. This retrospective study was conducted to investigate the risk 
      factors for and associated outcomes of AKI in pediatric liver transplant 
      recipients. METHODS: Eighty pediatric liver transplant patients were included. 
      The occurrence of AKI was defined by the KDIGO Clinical Practice Guidelines for 
      Acute Kidney Injury. A multivariate regression analysis model was used to 
      investigate risk factors for AKI in the pediatric liver recipients. RESULTS: The 
      final multivariable regression model showed that biliary atresia (odds ratio 
      [OR] = 0.097, p = 0.03), increased time of the anhepatic phase (OR = 0.871, 
      p = 0.005) and lower postoperative jaundice clearance (OR = 13.936, p = 0.02) 
      were independently associated with the development of AKI in pediatric patients. 
      Additionally, cumulative 3-year patient (p = 0.15) and graft (p = 0.26) survival 
      rates between the non-acute kidney injury (NAKI) and AKI groups were 95.2% vs 
      86.8% and 90.5% vs 84.2%, respectively. CONCLUSION: Pediatric liver transplant 
      recipients with a presence of biliary atresia, increased time of anhepatic phase, 
      and a lower postoperative jaundice clearance had an increased risk of AKI. The 
      long-term outcomes of patients who developed AKI appears to be worse compared 
      with those having NAKI. TYPE OF STUDY: Prognosis study. LEVEL OF EVIDENCE: Level 
      III.
CI  - Published by Elsevier Inc.
FAU - Zhang, Yimao
AU  - Zhang Y
AD  - West China of Hospital, Sichuan University, Department of Pediatric Surgery, No. 
      37 Guo Xue Xiang, Chengdu, Sichuan, China. Electronic address: 
      18482379056@163.com.
FAU - Xiang, Bo
AU  - Xiang B
AD  - West China of Hospital, Sichuan University, Department of Pediatric Surgery, No. 
      37 Guo Xue Xiang, Chengdu, Sichuan, China. Electronic address: 
      xb_scu.edu@hotmail.com.
FAU - Wu, Yang
AU  - Wu Y
AD  - West China of Hospital, Sichuan University, Department of Pediatric Surgery, No. 
      37 Guo Xue Xiang, Chengdu, Sichuan, China; West China of Hospital, Sichuan 
      University, Department of Pediatric Surgery, No.37 No. 37 Guo Xue Xiang, Chengdu, 
      Sichuan, China. Electronic address: 656478751@qq.com.
FAU - Xie, Xiaolong
AU  - Xie X
AD  - West China of Hospital, Sichuan University, Department of Pediatric Surgery, No. 
      37 Guo Xue Xiang, Chengdu, Sichuan, China. Electronic address: 517627231@qq.com.
FAU - Wang, Junxiang
AU  - Wang J
AD  - West China of Hospital, Sichuan University, Department of Pediatric Surgery, No. 
      37 Guo Xue Xiang, Chengdu, Sichuan, China. Electronic address: 349998135@qq.com.
FAU - Jin, Shuguang
AU  - Jin S
AD  - West China of Hospital, Sichuan University, Department of Pediatric Surgery, No. 
      37 Guo Xue Xiang, Chengdu, Sichuan, China. Electronic address: 
      shgjin2003@aliyun.com.
LA  - eng
PT  - Journal Article
DEP - 20190813
PL  - United States
TA  - J Pediatr Surg
JT  - Journal of pediatric surgery
JID - 0052631
SB  - IM
EIN - J Pediatr Surg. 2020 Apr;55(4):781. PMID: 32248903
MH  - *Acute Kidney Injury/epidemiology/etiology
MH  - Child
MH  - Humans
MH  - Liver Transplantation/*adverse effects
MH  - Postoperative Complications/*epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Outcomes
OT  - Pediatric liver transplantation
EDAT- 2019/08/31 06:00
MHDA- 2020/09/17 06:00
CRDT- 2019/08/31 06:00
PHST- 2019/04/18 00:00 [received]
PHST- 2019/07/29 00:00 [revised]
PHST- 2019/07/30 00:00 [accepted]
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2020/09/17 06:00 [medline]
PHST- 2019/08/31 06:00 [entrez]
AID - S0022-3468(19)30507-X [pii]
AID - 10.1016/j.jpedsurg.2019.07.019 [doi]
PST - ppublish
SO  - J Pediatr Surg. 2020 Mar;55(3):446-450. doi: 10.1016/j.jpedsurg.2019.07.019. Epub 
      2019 Aug 13.