PMID- 31467131 OWN - NLM STAT- MEDLINE DCOM- 20200713 LR - 20200713 IS - 1592-8721 (Electronic) IS - 0390-6078 (Print) IS - 0390-6078 (Linking) VI - 104 IP - 11 DP - 2019 Nov TI - Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies and after hematopoietic stem cell transplantation. PG - 2155-2163 LID - 10.3324/haematol.2019.223073 [doi] AB - Of the two human herpesvirus 6 (HHV-6) species, human herpesvirus 6B (HHV-6B) encephalitis is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant. Guidelines for the management of HHV-6 infections in patients with hematologic malignancies or post-transplant were prepared a decade ago but there have been no other guidelines since then despite significant advances in the understanding of HHV-6 encephalitis, its therapy, and other aspects of HHV-6 disease in this patient population. Revised guidelines prepared at the 2017 European Conference on Infections in Leukaemia covering diagnosis, preventative strategies and management of HHV-6 disease are now presented. CI - Copyright(c) 2019 Ferrata Storti Foundation. FAU - Ward, Katherine N AU - Ward KN AD - Division of Infection and Immunity, University College London, London, UK k.n.ward@ucl.ac.uk. FAU - Hill, Joshua A AU - Hill JA AD - Fred Hutchinson Cancer Research Center, Seattle, WA, USA. FAU - Hubacek, Petr AU - Hubacek P AD - Department of Medical Microbiology and Department of Paediatric Haematology and Oncology 2 Medical Faculty of Charles University and Motol University Hospital, Prague, Czech Republic. FAU - de la Camara, Rafael AU - de la Camara R AD - Department of Haematology, Hospital de la Princesa, Madrid, Spain. FAU - Crocchiolo, Roberto AU - Crocchiolo R AD - SIMT, ASST di Bergamo Ovest, Treviglio, Italy. FAU - Einsele, Hermann AU - Einsele H AD - Medizinische Klinik und Poliklinik II, Julius Maximilians Universitat, Wurzburg, Germany. FAU - Navarro, David AU - Navarro D AD - Microbiology Service, Hospital Clinico Universitario, Instituto de Investigacion INCLIVA and Department of Microbiology, School of Medicine, University of Valencia, Valencia, Spain. FAU - Robin, Christine AU - Robin C AD - Department of Haematology, Henri Mondor Hospital, Assistance Publique-Hopitaux de Paris, Universite Paris-Est Creteil, Creteil, France. FAU - Cordonnier, Catherine AU - Cordonnier C AD - Department of Haematology, Henri Mondor Hospital, Assistance Publique-Hopitaux de Paris, Universite Paris-Est Creteil, Creteil, France. FAU - Ljungman, Per AU - Ljungman P CN - 2017 European Conference on Infections in Leukaemia (ECIL) LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20190829 PL - Italy TA - Haematologica JT - Haematologica JID - 0417435 RN - 0 (Antiviral Agents) SB - IM MH - Antiviral Agents/pharmacology/therapeutic use MH - Cell Transformation, Viral MH - Combined Modality Therapy MH - Europe MH - Graft vs Host Disease/etiology MH - Hematologic Neoplasms/*complications/diagnosis/therapy MH - Hematopoietic Stem Cell Transplantation/adverse effects/methods MH - *Herpesvirus 6, Human MH - Humans MH - Immunocompromised Host MH - *Practice Guidelines as Topic MH - Roseolovirus Infections/*diagnosis/*etiology/*therapy MH - Treatment Outcome PMC - PMC6821622 EDAT- 2019/08/31 06:00 MHDA- 2020/07/14 06:00 PMCR- 2019/11/01 CRDT- 2019/08/31 06:00 PHST- 2019/04/01 00:00 [received] PHST- 2019/08/27 00:00 [accepted] PHST- 2019/08/31 06:00 [pubmed] PHST- 2020/07/14 06:00 [medline] PHST- 2019/08/31 06:00 [entrez] PHST- 2019/11/01 00:00 [pmc-release] AID - haematol.2019.223073 [pii] AID - 1042155 [pii] AID - 10.3324/haematol.2019.223073 [doi] PST - ppublish SO - Haematologica. 2019 Nov;104(11):2155-2163. doi: 10.3324/haematol.2019.223073. Epub 2019 Aug 29.