PMID- 31467405
OWN - NLM
STAT- MEDLINE
DCOM- 20200504
LR  - 20200805
IS  - 1474-1741 (Electronic)
IS  - 1474-1733 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jan
TI  - Dendritic cells in cancer immunology and immunotherapy.
PG  - 7-24
LID - 10.1038/s41577-019-0210-z [doi]
AB  - Dendritic cells (DCs) are a diverse group of specialized antigen-presenting cells 
      with key roles in the initiation and regulation of innate and adaptive immune 
      responses. As such, there is currently much interest in modulating DC function to 
      improve cancer immunotherapy. Many strategies have been developed to target DCs 
      in cancer, such as the administration of antigens with immunomodulators that 
      mobilize and activate endogenous DCs, as well as the generation of DC-based 
      vaccines. A better understanding of the diversity and functions of DC subsets and 
      of how these are shaped by the tumour microenvironment could lead to improved 
      therapies for cancer. Here we will outline how different DC subsets influence 
      immunity and tolerance in cancer settings and discuss the implications for both 
      established cancer treatments and novel immunotherapy strategies.
FAU - Wculek, Stefanie K
AU  - Wculek SK
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
FAU - Cueto, Francisco J
AU  - Cueto FJ
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain.
FAU - Mujal, Adriana M
AU  - Mujal AM
AD  - Department of Pathology, University of California, San Francisco, CA, USA.
AD  - Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Melero, Ignacio
AU  - Melero I
AD  - Division of Immunology and Immunotherapy, Center for Applied Medical Research, 
      University of Navarra, Pamplona, Spain.
AD  - Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain.
AD  - University Clinic, University of Navarra, Pamplona, Spain.
AD  - Centro de Investigacion Biomedica en Red Cancer, Madrid, Spain.
FAU - Krummel, Matthew F
AU  - Krummel MF
AUID- ORCID: 0000-0001-7915-3533
AD  - Department of Pathology, University of California, San Francisco, CA, USA.
FAU - Sancho, David
AU  - Sancho D
AUID- ORCID: 0000-0003-2890-3984
AD  - Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares 
      (CNIC), Madrid, Spain. dsancho@cnic.es.
LA  - eng
GR  - T32 AI007334/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190829
PL  - England
TA  - Nat Rev Immunol
JT  - Nature reviews. Immunology
JID - 101124169
SB  - IM
MH  - Animals
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Tolerance
MH  - *Immunotherapy
MH  - Neoplasms/*immunology/*therapy
EDAT- 2019/08/31 06:00
MHDA- 2020/05/06 06:00
CRDT- 2019/08/31 06:00
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2020/05/06 06:00 [medline]
PHST- 2019/08/31 06:00 [entrez]
AID - 10.1038/s41577-019-0210-z [pii]
AID - 10.1038/s41577-019-0210-z [doi]
PST - ppublish
SO  - Nat Rev Immunol. 2020 Jan;20(1):7-24. doi: 10.1038/s41577-019-0210-z. Epub 2019 
      Aug 29.