PMID- 31467766
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2090-8865 (Print)
IS  - 2090-8873 (Electronic)
IS  - 2090-8873 (Linking)
VI  - 2019
DP  - 2019
TI  - Simultaneous Determination of Over-the-Counter Pain Relievers in Commercial 
      Pharmaceutical Products Utilizing Multivariate Curve Resolution-Alternating Least 
      Squares (MCR-ALS) Multivariate Calibration Model.
PG  - 1863910
LID - 10.1155/2019/1863910 [doi]
LID - 1863910
AB  - The quality of over-the-counter (OTC) pain relievers is important to ensure the 
      safety of the marketed products in order to maintain the overall health care of 
      patients. In this study, the multivariate curve resolution-alternating least 
      squares (MCR-ALS) chemometric method was developed and validated for the 
      resolution and quantification of the most commonly consumed OTC pain relievers 
      (acetaminophen, acetylsalicylic acid, ibuprofen, naproxen, and caffeine) in 
      commercial drug formulations. The analytical performance of the developed 
      chemometric methods such as root mean square error of prediction, bias, standard 
      error of prediction, relative error of prediction, and coefficients of 
      determination was calculated for the developed model. The obtained results are 
      linear with concentration in the range of 0.5-7 mug/mL for acetaminophen and 
      0.5-3.5 and 0.5-3 mug/mL for naproxen and caffeine, respectively, while the 
      linearity ranges for acetyl salicylic acid and ibuprofen were 1-15 mug/mL. High 
      values of coefficients of determination >/=0.9995 reflected high predictive ability 
      of the developed model. Good recoveries ranging from 98.0% to 99.7% were obtained 
      for all analytes with relative standard deviations (RSDs) not higher than 1.62%. 
      The optimized method was successfully applied for the analysis of the studied 
      drugs either in their single or coformulated pharmaceutical products without any 
      separation step. The optimized method was also compared with a reported HPLC 
      method using paired t-test and F-ratio at 95% confidence level, and the results 
      showed no significant difference regarding accuracy and precision. The developed 
      method is eco-friendly, simple, fast, and amenable for routine analysis. It could 
      be used as a cost-effective alternative to chromatographic techniques for the 
      analysis of the studied drugs in commercial formulations.
FAU - Shaaban, Heba
AU  - Shaaban H
AUID- ORCID: 0000-0002-9522-6154
AD  - Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam 
      Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, 
      Saudi Arabia.
FAU - Mostafa, Ahmed
AU  - Mostafa A
AD  - Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam 
      Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, 
      Saudi Arabia.
FAU - Almatar, Zahra
AU  - Almatar Z
AD  - Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam 
      Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, 
      Saudi Arabia.
FAU - Alsheef, Reem
AU  - Alsheef R
AD  - Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam 
      Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, 
      Saudi Arabia.
FAU - Alrubh, Safia
AU  - Alrubh S
AD  - Department of Pharmaceutical Chemistry, College of Clinical Pharmacy, Imam 
      Abdulrahman Bin Faisal University, King Faisal Road, P.O. Box 1982, Dammam 31441, 
      Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20190731
PL  - Egypt
TA  - J Anal Methods Chem
JT  - Journal of analytical methods in chemistry
JID - 101575377
PMC - PMC6701297
COIS- The authors declare that they have no conflicts of interest to disclose.
EDAT- 2019/08/31 06:00
MHDA- 2019/08/31 06:01
PMCR- 2019/07/31
CRDT- 2019/08/31 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2019/06/26 00:00 [revised]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/08/31 06:00 [entrez]
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2019/08/31 06:01 [medline]
PHST- 2019/07/31 00:00 [pmc-release]
AID - 10.1155/2019/1863910 [doi]
PST - epublish
SO  - J Anal Methods Chem. 2019 Jul 31;2019:1863910. doi: 10.1155/2019/1863910. 
      eCollection 2019.