PMID- 31468664 OWN - NLM STAT- MEDLINE DCOM- 20210520 LR - 20210520 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 22 IP - 1 DP - 2020 Jan TI - Effects of sitagliptin on gastric emptying of, and the glycaemic and blood pressure responses to, a carbohydrate meal in type 2 diabetes. PG - 51-58 LID - 10.1111/dom.13864 [doi] AB - AIMS: To determine the effects of the dipeptidyl peptidase-4 inhibitor, sitagliptin, on gastric emptying (GE) of a high-carbohydrate meal and associated glycaemic and blood pressure (BP) responses in type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Fourteen patients with T2DM (nine men, five women; age 67.8 +/- 1.5 years; body mass index 31.2 +/- 0.9 kg/m(2) ; T2DM duration: 4.2 +/- 0.9 years; glycated haemoglobin: 46 +/- 1.8 mmol/mol [6.4% +/- 0.2%]), managed by diet and/or metformin, underwent concurrent measurements of GE, BP and plasma glucose for 240 minutes after ingestion of a radiolabelled mashed potato meal after receiving sitagliptin (100 mg) or placebo in randomized, double-blind, crossover fashion on 2 consecutive days. RESULTS: Sitagliptin reduced postprandial plasma glucose (P < .005) without affecting GE (P = .88). The magnitude of the glucose-lowering effect (change in incremental area under the curve(0-240 min) from placebo to sitagliptin) was related to GE (kcal/min) on placebo (r = 0.68, P = .008) There was a comparable fall in systolic BP (P = .80) following the meal, with no difference between the 2 days. CONCLUSIONS: In T2DM, while sitagliptin has no effect on either GE or postprandial BP, its ability to lower postprandial glucose are dependent on the basal rate of GE. CI - (c) 2019 John Wiley & Sons Ltd. FAU - Stevens, Julie E AU - Stevens JE AD - School of Health and Biomedical Sciences, RMIT University, Melbourne, Victoria, Australia. AD - Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia. AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. FAU - Buttfield, Madeline AU - Buttfield M AD - Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia. FAU - Wu, Tongzhi AU - Wu T AUID- ORCID: 0000-0003-1656-9210 AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. AD - Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia. FAU - Hatzinikolas, Seva AU - Hatzinikolas S AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. FAU - Pham, Hung AU - Pham H AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. FAU - Lange, Kylie AU - Lange K AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. FAU - Rayner, Christopher K AU - Rayner CK AUID- ORCID: 0000-0002-5527-256X AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. AD - Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia. FAU - Horowitz, Michael AU - Horowitz M AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. AD - Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia. FAU - Jones, Karen L AU - Jones KL AUID- ORCID: 0000-0002-1155-5816 AD - Division of Health Sciences, University of South Australia, Adelaide, South Australia, Australia. AD - Adelaide Medical School and NHMRC Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia. LA - eng GR - Royal Adelaide Hospital Research Foundation/International GR - University of Adelaide Beacon Research Fellowship/International GR - Royal Adelaide Hospital Florey Fellowship/International GR - National Health and Medical Research Council (NHMRC)/International PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20190930 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - 0 (Dietary Carbohydrates) RN - 0 (Hypoglycemic Agents) RN - TS63EW8X6F (Sitagliptin Phosphate) SB - IM MH - Aged MH - *Blood Glucose MH - *Blood Pressure MH - Cross-Over Studies MH - *Diabetes Mellitus, Type 2/drug therapy MH - Dietary Carbohydrates/administration & dosage MH - Double-Blind Method MH - Female MH - Gastric Emptying/*drug effects MH - Humans MH - Hypoglycemic Agents/therapeutic use MH - Male MH - Postprandial Period MH - *Sitagliptin Phosphate/therapeutic use OTO - NOTNLM OT - DPP-4 inhibition OT - blood pressure OT - glycaemia OT - postprandial hypotension OT - type 2 diabetes EDAT- 2019/08/31 06:00 MHDA- 2021/05/21 06:00 CRDT- 2019/08/31 06:00 PHST- 2019/07/09 00:00 [received] PHST- 2019/08/13 00:00 [revised] PHST- 2019/08/25 00:00 [accepted] PHST- 2019/08/31 06:00 [pubmed] PHST- 2021/05/21 06:00 [medline] PHST- 2019/08/31 06:00 [entrez] AID - 10.1111/dom.13864 [doi] PST - ppublish SO - Diabetes Obes Metab. 2020 Jan;22(1):51-58. doi: 10.1111/dom.13864. Epub 2019 Sep 30.