PMID- 31468999
OWN - NLM
STAT- MEDLINE
DCOM- 20200709
LR  - 20210312
IS  - 1365-2060 (Electronic)
IS  - 0785-3890 (Print)
IS  - 0785-3890 (Linking)
VI  - 51
IP  - 7-8
DP  - 2019 Nov-Dec
TI  - Efficacy and safety of fecal microbiota transplantation for decolonization of 
      intestinal multidrug-resistant microorganism carriage: beyond Clostridioides 
      difficile infection.
PG  - 379-389
LID - 10.1080/07853890.2019.1662477 [doi]
AB  - Persistent reservoirs of multidrug-resistant microorganisms (MDRO) that are 
      prevalent in hospital settings and communities can lead to the spread of MDRO. 
      Currently, there are no effective decolonization strategies, especially 
      non-pharmacological strategies without antibiotic regimens. Our aim was to 
      evaluate the efficacy and safety of fecal microbiota transplantation (FMT) for 
      the eradication of MDRO. A systematic literature search was performed to identify 
      studies on the use of FMT for the decolonization of MDRO. PubMed, EMBASE, Web of 
      Science, and Cochrane Library were searched from inception through January 2019. 
      Of the 1395 articles identified, 20 studies met the inclusion and exclusion 
      criteria. Overall, the efficacy of FMT for the eradication of each MDRO was 70.3% 
      (102/146) in 121 patients from the 20 articles. The efficacy rates were 68.2% 
      (30/44) for gram-positive bacteria and 70.6% (72/102) for gram-negative bacteria. 
      Minor adverse events, including vomiting, diarrhea, abdominal pain, and ileus, 
      were reported in patients who received FMT. FMT could be a promising strategy to 
      eradicate MDRO in patients. Further studies are needed to confirm these findings 
      and establish a comprehensive FMT protocol for standardized treatment.Key 
      messagesThe development of new antibiotics lags behind the emergence of 
      multidrug-resistant microorganisms (MDRO). New strategies are 
      needed.Theoretically, fecal microbiota transplantation (FMT) might recover the 
      diversity and function of commensal microbiota from dysbiosis in MDRO carriers 
      and help restore colonization resistance to pathogens.A literature review 
      indicated that FMT could be a promising strategy to eradicate MDRO in patients.
FAU - Yoon, Young Kyung
AU  - Yoon YK
AUID- ORCID: 0000-0001-8435-935X
AD  - Division of Infectious Diseases, Department of Internal Medicine, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Suh, Jin Woong
AU  - Suh JW
AUID- ORCID: 0000-0002-2259-4407
AD  - Division of Infectious Diseases, Department of Internal Medicine, Korea 
      University College of Medicine, Seoul, Korea.
FAU - Kang, Eun-Ji
AU  - Kang EJ
AUID- ORCID: 0000-0002-3916-9140
AD  - Korea University Medical Library, Seoul, Korea.
FAU - Kim, Jeong Yeon
AU  - Kim JY
AUID- ORCID: 0000-0001-7743-231X
AD  - Division of Infectious Diseases, Department of Internal Medicine, Korea 
      University College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20190913
PL  - England
TA  - Ann Med
JT  - Annals of medicine
JID - 8906388
SB  - IM
MH  - *Drug Resistance, Multiple, Bacterial
MH  - *Fecal Microbiota Transplantation
MH  - *Gastrointestinal Microbiome
MH  - Humans
PMC - PMC7877873
OTO - NOTNLM
OT  - Clostridioides difficile
OT  - Multidrug-resistant bacteria
OT  - fecal microbiota transplantation
OT  - gastrointestinal microbiome
OT  - systematic review
COIS- The authors report no conflicts of interest in this work.
EDAT- 2019/08/31 06:00
MHDA- 2020/07/10 06:00
PMCR- 2019/09/13
CRDT- 2019/08/31 06:00
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2020/07/10 06:00 [medline]
PHST- 2019/08/31 06:00 [entrez]
PHST- 2019/09/13 00:00 [pmc-release]
AID - 1662477 [pii]
AID - 10.1080/07853890.2019.1662477 [doi]
PST - ppublish
SO  - Ann Med. 2019 Nov-Dec;51(7-8):379-389. doi: 10.1080/07853890.2019.1662477. Epub 
      2019 Sep 13.