PMID- 31469245
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20200518
IS  - 2328-9503 (Electronic)
IS  - 2328-9503 (Linking)
VI  - 6
IP  - 9
DP  - 2019 Sep
TI  - Human leukocyte antigen-DQB1 polymorphisms and haplotype patterns in 
      Guillain-Barre syndrome.
PG  - 1849-1857
LID - 10.1002/acn3.50884 [doi]
AB  - OBJECTIVE: The etiology of Guillain-Barre syndrome (GBS) remains enigmatic, 
      although genetic and environmental factors are speculated to be associated with 
      this autoimmune condition. We investigated whether polymorphisms and the 
      haplotype structures of the human leukocyte antigen (HLA)-DQB1 gene relate to the 
      autoimmune response to infection and affect the development of GBS. METHODS: 
      HLA-DQB1 polymorphic alleles (*0201, *030x, *0401, *050x, *060x) were determined 
      for 151 Bangladeshi patients with GBS and 151 ethnically matched healthy controls 
      using sequence-specific polymerase chain reaction. Pairwise linkage 
      disequilibrium (LD) and haplotype patterns were analyzed based on D ́statistics 
      and the genotype package in R statistics, respectively. Association studies were 
      conducted using Fisher's exact test and logistic regression analysis. The 
      Bonferroni method was applied to correct for multiple comparisons, whereby the 
      P-value was multiplied with the number of comparisons and denoted as Pc (Pc, P 
      corrected). RESULTS: No associations were observed between HLA-DQB1 alleles and 
      susceptibility to disease in the comparison between GBS patients and healthy 
      subjects. Haplotype 9 (DQB1*0303-*0601) tended to be less frequent among patients 
      with GBS than healthy controls (P = 0.006, OR = 0.49, 95% CI = 0.30-0.82; 
      Pc = 0.06). Haplotype 5 (DQB1*0501-*0602) and the DQB1*0201 alleles were more 
      frequent in the Campylobacter jejuni-triggered axonal variant of GBS (P = 0.024, 
      OR = 4.06, 95% CI = 1.25-13.18; Pc = 0.24) and demyelinating subtype (P = 0.027, 
      OR = 2.68, 95% CI = 1.17-6.17; Pc = 0.35), though these associations were not 
      significant after Bonferroni correction. INTERPRETATION: This study indicates 
      that HLA-DQB1 polymorphisms are not associated with susceptibility to GBS. In 
      addition, these genetic markers did not influence the clinical features or 
      serological subgroup in patients with C. jejuni-triggered axonal variant of GBS.
CI  - (c) 2019 The Authors. Annals of Clinical and Translational Neurology published by 
      Wiley Periodicals, Inc on behalf of American Neurological Association.
FAU - Hayat, Shoma
AU  - Hayat S
AD  - Laboratory Sciences and Services Division (LSSD), icddr,b, Dhaka, 1212, 
      Bangladesh.
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 
      1000, Bangladesh.
FAU - Jahan, Israt
AU  - Jahan I
AD  - Laboratory Sciences and Services Division (LSSD), icddr,b, Dhaka, 1212, 
      Bangladesh.
FAU - Das, Avizit
AU  - Das A
AD  - Laboratory Sciences and Services Division (LSSD), icddr,b, Dhaka, 1212, 
      Bangladesh.
FAU - Hassan, Zahid
AU  - Hassan Z
AD  - Department of Physiology and Molecular Biology, Bangladesh, University of Health 
      Sciences (BUHS), Dhaka, 1216, Bangladesh.
FAU - Howlader, Zakir Hossain
AU  - Howlader ZH
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 
      1000, Bangladesh.
FAU - Mahmud, Ishtiaq
AU  - Mahmud I
AD  - Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, 
      1000, Bangladesh.
FAU - Deen Mohammad, Quazi
AU  - Deen Mohammad Q
AD  - National Institute of Neurosciences and Hospital, Dhaka, 1207, Bangladesh.
FAU - Islam, Zhahirul
AU  - Islam Z
AUID- ORCID: 0000-0003-0935-8079
AD  - Laboratory Sciences and Services Division (LSSD), icddr,b, Dhaka, 1212, 
      Bangladesh.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190830
PL  - United States
TA  - Ann Clin Transl Neurol
JT  - Annals of clinical and translational neurology
JID - 101623278
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Guillain-Barre Syndrome/*genetics/immunology
MH  - HLA-DQ beta-Chains/*genetics
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Young Adult
PMC - PMC6764492
COIS- The authors do not have any conflict of interest to report.
EDAT- 2019/08/31 06:00
MHDA- 2020/05/19 06:00
PMCR- 2019/08/30
CRDT- 2019/08/31 06:00
PHST- 2019/06/16 00:00 [received]
PHST- 2019/07/29 00:00 [revised]
PHST- 2019/08/11 00:00 [accepted]
PHST- 2019/08/31 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/08/31 06:00 [entrez]
PHST- 2019/08/30 00:00 [pmc-release]
AID - ACN350884 [pii]
AID - 10.1002/acn3.50884 [doi]
PST - ppublish
SO  - Ann Clin Transl Neurol. 2019 Sep;6(9):1849-1857. doi: 10.1002/acn3.50884. Epub 
      2019 Aug 30.