PMID- 31470836
OWN - NLM
STAT- MEDLINE
DCOM- 20200210
LR  - 20200225
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 19
IP  - 1
DP  - 2019 Aug 30
TI  - Severe hypertriglyceridemia in a subject with disturbed life style and poor 
      glycemic control without recurrence of acute pancreatitis: a case report.
PG  - 92
LID - 10.1186/s12902-019-0425-9 [doi]
LID - 92
AB  - BACKGROUND: Hypertriglyceridemia is often observed as the result of lipid 
      abnormality and frequently associated with other lipid and metabolic disorders. 
      Aggravation of hypertriglyceridemia is caused by various conditions. However, 
      severe hypertriglyceridemia is usually induced by an addition of some secondary 
      clinical conditions such as uncontrolled type 2 diabetes mellitus (T2DM) and 
      obesity with insulin resistance. CASE PRESENTATION: A 40-year-old man with 4-year 
      history of dyslipidemia and T2DM visited after his interruption of therapy for 
      about 1.5 years. His past history was acute pancreatitis. His life style was 
      markedly disturbed, and he had a lot of risk factors for hypertriglyceridemia. 
      Surprisingly, his serum triglyceride level was as high as 16,900 mg/dL. His 
      aggravation and remission of hypertriglyceridemia were closely associated with 
      the alteration of RLP-cholesterol levels in dyslipidemia and glycoalbumin and 
      ketone body levels in T2DM. CONCLUSION: We report very severe 
      hypertriglyceridemia, which seemed to be caused by markedly disturbed life style 
      and poorly controlled T2DM. Total therapy with diet and drug for each disease is 
      very important for the improvement of very severe hypertriglyceridemia. This case 
      report suggests that very severe hypertriglyceridemia alone does not necessarily 
      bring out acute pancreatitis, although it is very important to check pancreatitis 
      markers in such a situation.
FAU - Irie, Shintaro
AU  - Irie S
AD  - Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 
      Nakasange, Kita-ku, Okayama, 700-8505, Japan.
FAU - Anno, Takatoshi
AU  - Anno T
AUID- ORCID: 0000-0002-7862-3385
AD  - Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 
      Nakasange, Kita-ku, Okayama, 700-8505, Japan. anno-t@umin.ac.jp.
FAU - Kawasaki, Fumiko
AU  - Kawasaki F
AD  - Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 
      Nakasange, Kita-ku, Okayama, 700-8505, Japan.
FAU - Shigemoto, Ryo
AU  - Shigemoto R
AD  - Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 
      Nakasange, Kita-ku, Okayama, 700-8505, Japan.
FAU - Nakanishi, Shuhei
AU  - Nakanishi S
AD  - Department of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 
      Kurashiki, 701-0192, Japan.
FAU - Kaku, Kohei
AU  - Kaku K
AD  - Department of General Internal Medicine 1, Kawasaki Medical School, 2-6-1 
      Nakasange, Kita-ku, Okayama, 700-8505, Japan.
FAU - Kaneto, Hideaki
AU  - Kaneto H
AD  - Department of Diabetes, Metabolism and Endocrinology, Kawasaki Medical School, 
      Kurashiki, 701-0192, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190830
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Humans
MH  - Hyperglycemia/*complications
MH  - Hypertriglyceridemia/etiology/*pathology
MH  - *Life Style
MH  - Male
MH  - *Pancreatitis
MH  - Prognosis
MH  - Recurrence
PMC - PMC6717367
OTO - NOTNLM
OT  - After pancreatitis
OT  - Insulin effect
OT  - Poor glycemic control
OT  - Severe hypertriglyceridemia
COIS- The authors declare that they have no competing interests.
EDAT- 2019/09/01 06:00
MHDA- 2020/02/11 06:00
PMCR- 2019/08/30
CRDT- 2019/09/01 06:00
PHST- 2019/04/09 00:00 [received]
PHST- 2019/08/26 00:00 [accepted]
PHST- 2019/09/01 06:00 [entrez]
PHST- 2019/09/01 06:00 [pubmed]
PHST- 2020/02/11 06:00 [medline]
PHST- 2019/08/30 00:00 [pmc-release]
AID - 10.1186/s12902-019-0425-9 [pii]
AID - 425 [pii]
AID - 10.1186/s12902-019-0425-9 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2019 Aug 30;19(1):92. doi: 10.1186/s12902-019-0425-9.