PMID- 31471338
OWN - NLM
STAT- MEDLINE
DCOM- 20200123
LR  - 20200123
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 49
IP  - 4
DP  - 2019 Sep
TI  - Association of Complement and Inflammatory Biomarkers with Diabetic Nephropathy.
PG  - 488-495
AB  - OBJECTIVE: To investigate the association between complement and inflammatory 
      biomarkers with diabetic nephropathy (DN) in type 2 diabetes mellitus (T2DM). 
      METHODS: Plasma and urinary complement and inflammatory biomarkers were measured 
      in 115 T2DM patients assigned to one of two groups: with DN (n=48) and without DN 
      (n=67). RESULTS: The plasma and urinary levels of C3a, C4d, C5a, sC5b-9 and MBL 
      (mannan-binding lectin) were significantly higher in T2DM patients with DN 
      compared to T2DM patients without DN. The plasma levels of IL-10 and INF-gamma, as 
      well as the urinary levels of INF-gamma and TNF-alpha in T2DM patients with DN, were 
      significantly higher than T2DM patients without DN. Both urinary MBL and INF-gamma 
      were independent risk factors for DN within T2DM patients (OR, 2.35 (95% CI 
      2.28-2.64) and 1.17 (95% CI 1.15-1.18); P=0.000 and 0.016, respectively). The 
      area under the receiver-operating-characteristic-curve for urinary MBL was 0.89, 
      with sensitivity 91% and specificity 83% for DN. The area under the 
      receiver-operating-characteristic-curve for INF-gamma was 0.84, with sensitivity 86% 
      and specificity 79% based on cutoff values of 1.42 ng/mg and 5.15 pg/mg, 
      respectively. CONCLUSION: This study suggests that urinary INF-gamma and MBL levels 
      are independent risk factors with a high predictive power for DN in T2DM 
      patients.
CI  - (c) 2019 by the Association of Clinical Scientists, Inc.
FAU - Huang, Huiya
AU  - Huang H
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan.
AD  - Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou 
      Medical University, Wenzhou.
FAU - Li, Dengren
AU  - Li D
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan.
FAU - Huang, Xiaozhong
AU  - Huang X
AD  - Department of Pediatric Surgery, The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University, Wenzhou.
FAU - Wang, Ying
AU  - Wang Y
AD  - Department of Pharmacy, Jinhua Women & Children Health Hospital, Jinhua, China.
FAU - Wang, Shiyuan
AU  - Wang S
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan.
FAU - Wang, Ximei
AU  - Wang X
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan.
FAU - Yang, Xiangdong
AU  - Yang X
AD  - Department of Nephrology, Qilu Hospital of Shandong University, Jinan 
      yxd683@163.com.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
RN  - 9007-36-7 (Complement System Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Biomarkers/*blood/urine
MH  - Complement System Proteins/*metabolism/urine
MH  - Diabetic Nephropathies/*blood/urine
MH  - Female
MH  - Humans
MH  - Inflammation/*blood/urine
MH  - Inflammation Mediators/blood/urine
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - ROC Curve
OTO - NOTNLM
OT  - Complement activation
OT  - Diabetic nephropathy
OT  - Inflammatory cytokine
OT  - Risk factor
OT  - Type 2 diabetes mellitus
EDAT- 2019/09/01 06:00
MHDA- 2020/01/24 06:00
CRDT- 2019/09/01 06:00
PHST- 2019/09/01 06:00 [entrez]
PHST- 2019/09/01 06:00 [pubmed]
PHST- 2020/01/24 06:00 [medline]
AID - 49/4/488 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2019 Sep;49(4):488-495.