PMID- 31473973
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20221207
IS  - 1179-2000 (Electronic)
IS  - 1177-1062 (Linking)
VI  - 23
IP  - 6
DP  - 2019 Dec
TI  - HLA Correlations with Clinical Phenotypes and Risk of Metabolic Comorbidities in 
      Singapore Chinese Psoriasis Patients.
PG  - 751-760
LID - 10.1007/s40291-019-00423-z [doi]
AB  - INTRODUCTION: Psoriasis is a systemic, chronic inflammatory disease that not only 
      afflicts the skin but is also associated with cardiovascular disease and 
      metabolic syndrome. The strongest susceptibility loci for the disease is within 
      the human leukocyte antigen (HLA) complex, though specific HLA allelic 
      associations vary between populations. OBJECTIVE: Our objective was to 
      investigate HLA associations with clinical phenotypes of psoriasis and metabolic 
      syndrome in Chinese psoriasis cases. METHODS: We conducted an observational 
      case-control study in Singapore with a cohort of psoriasis cases consecutively 
      recruited from an outpatient specialist dermatological center (n = 120) compared 
      with 130 healthy controls. RESULTS: Significant HLA associations with psoriasis 
      were observed with HLA-A*02:07, B*46:01, C*01:02, and C*06:02. The three-locus 
      haplotype of A*02:07-C*01:02-B*46:01 was also significant (odds ratio [OR] 3.07; 
      p = 9.47 x 10(-5)). We also observed an association between nail psoriasis and 
      HLA-A*02:07 carriers (OR 4.50; p = 0.002), whereas C*06:02 carriers were less 
      prone to have nail involvement (OR 0.16; p = 0.004). HLA-A*02:07 was also 
      identified as a possible risk allele for hypertension (OR 2.90; p < 0.05), and 
      C*01:02 was a possible risk allele for dyslipidemia (OR 3.36; p < 0.05), both 
      known to be common comorbidities in patients with psoriasis. CONCLUSION: Our 
      results demonstrate the growing importance of discerning population-specific 
      clinical phenotypes and their association with certain HLA alleles in psoriasis.
FAU - Shen, Meixin
AU  - Shen M
AD  - Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, #03-06, Immunos 
      Building, Singapore, 138648, Singapore.
FAU - Lim, Soon Wei Daniel
AU  - Lim SWD
AD  - John A. Paulson School of Engineering and Applied Sciences, Harvard University, 
      Cambridge, Massachusetts, USA.
FAU - Tan, Eugene S
AU  - Tan ES
AD  - National Skin Centre (S) Pte Ltd, 1 Mandalay Rd, Singapore, 308205, Singapore.
FAU - Oon, Hazel H
AU  - Oon HH
AD  - National Skin Centre (S) Pte Ltd, 1 Mandalay Rd, Singapore, 308205, Singapore. 
      hazeloon@nsc.com.sg.
FAU - Ren, Ee Chee
AU  - Ren EC
AUID- ORCID: 0000-0001-5039-2207
AD  - Singapore Immunology Network (SIgN), A*STAR, 8A Biomedical Grove, #03-06, Immunos 
      Building, Singapore, 138648, Singapore. ren_ee_chee@immunol.a-star.edu.sg.
AD  - Department of Microbiology and Immunology, National University of Singapore, 5 
      Science Drive 2, MD4, Level 3, Singapore, 117545, Singapore. 
      ren_ee_chee@immunol.a-star.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Dyslipidemias/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Hypertension/*genetics
MH  - Male
MH  - Middle Aged
MH  - Psoriasis/*genetics
MH  - Singapore/ethnology
MH  - Young Adult
EDAT- 2019/09/02 06:00
MHDA- 2020/05/19 06:00
CRDT- 2019/09/02 06:00
PHST- 2019/09/02 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/09/02 06:00 [entrez]
AID - 10.1007/s40291-019-00423-z [pii]
AID - 10.1007/s40291-019-00423-z [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2019 Dec;23(6):751-760. doi: 10.1007/s40291-019-00423-z.