PMID- 31474455
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20210927
IS  - 1477-2574 (Electronic)
IS  - 1365-182X (Linking)
VI  - 22
IP  - 4
DP  - 2020 Apr
TI  - Embolization with microspheres alone for hepatocellular carcinoma with portal 
      vein tumor: analysis of outcome and liver function at disease progression.
PG  - 588-594
LID - S1365-182X(19)30689-6 [pii]
LID - 10.1016/j.hpb.2019.08.004 [doi]
AB  - BACKGROUND: This retrospective study reviews long-term outcome of hepatic artery 
      embolization (HAE) using microspheres alone in patients presenting with 
      Hepatocellular Carcinoma (HCC) and portal vein tumor (PVT). METHODS: From 2005 to 
      2015, 43 patients with HCC and PVT underwent HAE. Response to treatment, 
      time-to-progression (TTP), local-tumor-progression (LTP), 
      distant-hepatic-progression (DHP), PVT-progression (PVTP), and/or the development 
      of extra-hepatic progression (EHP) were assessed on pre-HAE CT/MRI scans, within 
      4 weeks post-HAE and at quarterly intervals thereafter, along with liver function 
      (Child-Pugh score, CP). RESULTS: Forty (40/43) patients progressed during a 
      median follow-up of 10 months with a median TTP of 2.9 months. Eleven of the 40 
      patients (27.5%) developed EHP, with only 2 patients (5%) demonstrating solely 
      LTP. Six patients (15%) developed PVTP only. At progression, 27 patients (27/40, 
      77%) maintained their initial CP status, including all 5 CP-B patients. Median 
      survival was 12.5 (95% CI 8-23) months for the entire group; 17.3 (95% CI 10-33) 
      months for the patients with segmental/lobar PVT, compared with 8.4 (95% CI 6-13) 
      months for the patients with main PVT (p = 0.02). CONCLUSION: HAE can be used to 
      treat patients with HCC and PVT with median survival of approximately a year and 
      preserved liver function.
CI  - Copyright (c) 2019 International Hepato-Pancreato-Biliary Association Inc. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Borgheresi, Alessandra
AU  - Borgheresi A
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA.
FAU - Covey, Anne
AU  - Covey A
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Yarmohammadi, Hooman
AU  - Yarmohammadi H
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Boas, Franz E
AU  - Boas FE
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Ziv, Etay
AU  - Ziv E
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Getrajdman, George
AU  - Getrajdman G
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Erinjeri, Joseph
AU  - Erinjeri J
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Jarnagin, William
AU  - Jarnagin W
AD  - Department of Surgery, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Harding, James J
AU  - Harding JJ
AD  - Department of Medicine Memorial Sloan Kettering Cancer Center, 1275 York Avenue, 
      New York, NY, 10065, USA; Weil Cornell Medical College, 1300 York Avenue, New 
      York, NY, 10065, USA.
FAU - D'Angelica, Michael
AU  - D'Angelica M
AD  - Department of Surgery, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA.
FAU - Gonen, Mithat
AU  - Gonen M
AD  - Department of Biostatistics, Memorial Sloan Kettering Cancer Center, 485 
      Lexington Avenue, New York, NY 10017, USA.
FAU - Brown, Karen T
AU  - Brown KT
AD  - Department of Radiology, 1275 York Avenue, New York, NY, 10065, USA; Weil Cornell 
      Medical College, 1300 York Avenue, New York, NY, 10065, USA. Electronic address: 
      karen.brown@utah.edu.
LA  - eng
PT  - Journal Article
DEP - 20190829
PL  - England
TA  - HPB (Oxford)
JT  - HPB : the official journal of the International Hepato Pancreato Biliary 
      Association
JID - 100900921
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Hepatocellular/mortality/pathology/*therapy
MH  - Disease Progression
MH  - *Embolization, Therapeutic
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/mortality/pathology/*therapy
MH  - Male
MH  - *Microspheres
MH  - Middle Aged
MH  - *Portal Vein
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2019/09/03 06:00
MHDA- 2021/09/28 06:00
CRDT- 2019/09/03 06:00
PHST- 2019/04/16 00:00 [received]
PHST- 2019/07/08 00:00 [revised]
PHST- 2019/08/07 00:00 [accepted]
PHST- 2019/09/03 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2019/09/03 06:00 [entrez]
AID - S1365-182X(19)30689-6 [pii]
AID - 10.1016/j.hpb.2019.08.004 [doi]
PST - ppublish
SO  - HPB (Oxford). 2020 Apr;22(4):588-594. doi: 10.1016/j.hpb.2019.08.004. Epub 2019 
      Aug 29.