PMID- 31474708
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20200127
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 42
IP  - 9
DP  - 2019
TI  - A Modified Formulation of Sutaehwan Ameliorates Menopausal Anxiety, Depression 
      and Heart Hypertrophy in the VCD-Induced Menopausal Mouse Model.
PG  - 1471-1481
LID - 10.1248/bpb.b19-00056 [doi]
AB  - Sutaehwan (STH) has been used in Korean medicine for the treatment of abortus 
      habitualis such as fetal restlessness in the uterus. Previously, we reported that 
      a modified formulation of STH, Sutaehwan-Gami, has phytoestrogen-like properties 
      in an ovariectomized menopausal rat model. However, the therapeutic effects of 
      STH and the precise mechanisms by which STH affects various menopausal symptoms 
      remain poorly understood. The current study was designed to explore the effects 
      of a modified form of STH on menopausal anxiety, depression and heart hypertrophy 
      and its mechanisms in 4-vinylcyclohexene diepoxide (VCD)-induced menopausal mouse 
      models. VCD-induced menopausal model mice were fed a modified form of STH, which 
      contained water extract of 3 herbs (called STH_KP17001) at a dose of 100 or 
      300 mg/kg/d or as a positive control, estradiol at a dose of 0.2 mg/kg/d with 
      standard mouse pellets for 13 weeks. The results show that STH_KP17001 
      significantly restored the VCD-induced weight reduction of uterine and ovary 
      through the phosphorylation of extracellular signal-regulated kinase (ERK) and 
      protein kinase B (AKT) in the uterus and ovary. Moreover, STH_KP17001 showed 
      slight proliferative effects and estrogen receptor alpha phosphorylation in MCF-7 
      cells. Treatment with STH_KP17001 reversed VCD-induced anxiety and depression 
      through AMP-activated protein kinase (AMPK) activation and brain-derived 
      neurotrophic factor (BDNF) expression in the cerebral cortex, while improving 
      heart hypertrophy through inactivation of inhibitor of kappaB alpha (IkappaBalpha) in the 
      heart. The results indicate that STH_KP17001 improves menopause-induced anxiety, 
      depression and heart hypertrophy, implying its protective role for the management 
      of menopausal symptoms.
FAU - Kim, Deokho
AU  - Kim D
AD  - Department of Korean Medicine, Graduate School of Dongguk University.
FAU - Liu, Quan Feng
AU  - Liu QF
AD  - Department of Neuropsychiatry, Graduate School of Oriental Medicine, Dongguk 
      University.
FAU - Jeong, Ha Jin
AU  - Jeong HJ
AD  - Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical 
      Scientists at Chonnam National University.
FAU - Han, Seung-Hee
AU  - Han SH
AD  - Central Research Laboratory, KOREA PHARMA Co., Ltd.
FAU - Kim, Dong-Il
AU  - Kim DI
AD  - Department of Obstetrics & Gynecology, College of Korean Medicine, Dongguk 
      University.
FAU - Jeon, Songhee
AU  - Jeon S
AD  - Department of Biomedical Sciences, BK21 PLUS Center for Creative Biomedical 
      Scientists at Chonnam National University.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Cyclohexenes)
RN  - 0 (Plant Extracts)
RN  - 0 (Vinyl Compounds)
RN  - 596C064IG4 (4-vinyl-1-cyclohexene dioxide)
SB  - IM
MH  - Animals
MH  - Anxiety/*prevention & control
MH  - Cardiomegaly/*prevention & control
MH  - Cyclohexenes
MH  - Depression/*prevention & control
MH  - Disease Models, Animal
MH  - Female
MH  - Humans
MH  - MCF-7 Cells
MH  - Medicine, Korean Traditional
MH  - Menopause/*psychology
MH  - Mice, Inbred C57BL
MH  - Plant Extracts/isolation & purification/*pharmacology
MH  - Vinyl Compounds
OTO - NOTNLM
OT  - 4-vinylcyclohexene diepoxide (VCD)
OT  - AMP-activated protein kinase (AMPK)
OT  - Sutaehwan
OT  - depression
OT  - heart hypertrophy
OT  - menopause
EDAT- 2019/09/03 06:00
MHDA- 2020/01/28 06:00
CRDT- 2019/09/03 06:00
PHST- 2019/09/03 06:00 [entrez]
PHST- 2019/09/03 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
AID - 10.1248/bpb.b19-00056 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2019;42(9):1471-1481. doi: 10.1248/bpb.b19-00056.