PMID- 31475273
OWN - NLM
STAT- MEDLINE
DCOM- 20200721
LR  - 20200721
IS  - 2050-7518 (Electronic)
IS  - 2050-750X (Linking)
VI  - 7
IP  - 37
DP  - 2019 Oct 7
TI  - Supramolecular micellar drug delivery system based on multi-arm block copolymer 
      for highly effective encapsulation and sustained-release chemotherapy.
PG  - 5677-5687
LID - 10.1039/c9tb01221d [doi]
AB  - Poly(phosphoester)-based biomaterials have great potential in drug delivery 
      systems (DDSs) because of their multifunctional adjustability, stealth effect, 
      excellent biodegradability, and biocompatibility. To further increase the drug 
      loading efficiency (DLE) and sustained release ability, a multi-arm block 
      copolymer, poly(amido amine)-b-poly(2-butenyl phospholane)-b-poly(2-methoxy 
      phospholane) conjugated with folic acid (abbreviated as PAMAM-PBEP-PMP-FA), was 
      designed and prepared. Compared to the traditional linear copolymers, this 
      multi-arm phosphoester block copolymer integrates a balanced combination of 
      unique features. As an advanced DDS, the PAMAM-PBEP-PMP-FA based supramolecular 
      micelle provides good architectural stability, low protein adsorption, extremely 
      high DLE, and sustained drug release for chemotherapy and abundant surface 
      chemistry for target engineering. Benefitting from these novel functions, the 
      supramolecular micellar drug delivery system exhibits great performances both in 
      in vitro and in vivo evaluations. Doxorubicin (DOX)-loaded supramolecular 
      micelles PAMAM-PBEP-PMP-FA/DOX are fast taken up by HepG2 cells and inhibit the 
      tumor growth effectively in HepG2-tumor-bearing nude mice without obvious system 
      toxicity. This work not only suggests a targeted sustained release DDS for 
      effective chemotherapy but also enlightens, through a delicate design at the 
      molecular scale, the brilliance of multifunctional PPE-based nanomaterials 
      towards versatile bio-applications.
FAU - Zhang, Li
AU  - Zhang L
AD  - Key Laboratory of Synthetic and Biological Colloids Ministry of Education, School 
      of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, 
      China. mqchen@jiangnan.edu.cn djshi@jiangnan.edu.cn.
FAU - Shi, Dongjian
AU  - Shi D
AUID- ORCID: 0000-0003-4477-2929
AD  - Key Laboratory of Synthetic and Biological Colloids Ministry of Education, School 
      of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, 
      China. mqchen@jiangnan.edu.cn djshi@jiangnan.edu.cn.
FAU - Shi, Chunling
AU  - Shi C
AD  - School of Chemistry and Chemical Engineering, Xuzhou Institute of Technology, 
      Xuzhou, Jiangsu 221111, China.
FAU - Kaneko, Tatsuo
AU  - Kaneko T
AUID- ORCID: 0000-0001-9794-083X
AD  - Graduate School of Advanced Science and Technology, Japan Advanced Institute of 
      Science and Technology (JAIST), Ishikawa, 923-1292, Japan.
FAU - Chen, Mingqing
AU  - Chen M
AD  - Key Laboratory of Synthetic and Biological Colloids Ministry of Education, School 
      of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, 
      China. mqchen@jiangnan.edu.cn djshi@jiangnan.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190902
PL  - England
TA  - J Mater Chem B
JT  - Journal of materials chemistry. B
JID - 101598493
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Micelles)
RN  - 0 (Polymers)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Animals
MH  - Carcinogenesis/*drug effects
MH  - Cell Survival
MH  - Delayed-Action Preparations/*chemistry
MH  - Doxorubicin/administration & dosage
MH  - Hep G2 Cells
MH  - Humans
MH  - Mice
MH  - Mice, Nude
MH  - Micelles
MH  - Neoplasms/*drug therapy
MH  - Polymers/chemistry
MH  - Xenograft Model Antitumor Assays
EDAT- 2019/09/03 06:00
MHDA- 2020/07/22 06:00
CRDT- 2019/09/03 06:00
PHST- 2019/09/03 06:00 [pubmed]
PHST- 2020/07/22 06:00 [medline]
PHST- 2019/09/03 06:00 [entrez]
AID - 10.1039/c9tb01221d [doi]
PST - ppublish
SO  - J Mater Chem B. 2019 Oct 7;7(37):5677-5687. doi: 10.1039/c9tb01221d. Epub 2019 
      Sep 2.