PMID- 31475415
OWN - NLM
STAT- MEDLINE
DCOM- 20200220
LR  - 20200220
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 33
IP  - 12
DP  - 2019 Dec
TI  - The Effect of Resveratrol Supplementation on Cardio-Metabolic Risk Factors in 
      Patients with Type 2 Diabetes: A Randomized, Double-Blind Controlled Trial.
PG  - 3153-3162
LID - 10.1002/ptr.6487 [doi]
AB  - The aim of the present randomized controlled trial was to evaluate the effect of 
      a micronized resveratrol supplement on glycemic status, lipid profile, and body 
      composition in patients with type 2 diabetes mellitus (T2DM). A total of 71 
      overweight patients with T2DM (body mass index ranged 25-30) were randomly 
      assigned to receive 1000 mg/day trans-resveratrol or placebo (methyl cellulose) 
      for 8 weeks. Anthropometric indices and biochemical indices including lipid and 
      glycemic profile were measured before and after the intervention. In adjusted 
      model (age, sex, and baseline body mass index), resveratrol decreased fasting 
      blood sugar (-7.97+/-13.6 mg/dL, p=0.05) and increased high density lipoprotein 
      (3.62+/-8.75 mg/dL, p=0.01) levels compared with placebo. Moreover, the mean 
      difference in insulin levels reached significance (-0.97+/-1.91, muIU/mL, p= 0.02). 
      However, no significant differences were observed for anthropometric measures. It 
      was found that 8-week resveratrol supplementation produced useful effects on some 
      cardio-metabolic parameters in patients with T2DM. More studies are needed to 
      confirm these findings.
CI  - (c) 2019 John Wiley & Sons, Ltd.
FAU - Abdollahi, Shima
AU  - Abdollahi S
AUID- ORCID: 0000-0002-2638-7448
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Department of Nutrition and Public Health, School of Public Health, North 
      Khorasan University of Medical Sciences, Bojnurd, Iran.
FAU - Salehi-Abargouei, Amin
AU  - Salehi-Abargouei A
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Toupchian, Omid
AU  - Toupchian O
AD  - Department of Nutrition and Public Health, School of Public Health, North 
      Khorasan University of Medical Sciences, Bojnurd, Iran.
FAU - Sheikhha, Mohammad Hasan
AU  - Sheikhha MH
AD  - Department of Genetics, School of Medicine, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
AD  - Yazd Clinical and Research Center for Infertility, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Fallahzadeh, Hossein
AU  - Fallahzadeh H
AD  - Department of Biostatistics and Epidemiology, Research Center of Prevention and 
      Epidemiology of Non-Communicable Disease, School of Health, Shahid Sadoughi 
      University of Medical Sciences, Yazd, Iran.
FAU - Rahmanian, Masoud
AU  - Rahmanian M
AD  - Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
FAU - Tabatabaie, Mahtab
AU  - Tabatabaie M
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Nutrition and Food Security Research Center, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
FAU - Mozaffari-Khosravi, Hassan
AU  - Mozaffari-Khosravi H
AD  - Department of Nutrition, School of Public Health, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Yazd Diabetic Research Center, Shahid Sadoughi University of Medical Sciences, 
      Yazd, Iran.
LA  - eng
GR  - 96010660/Iran's National Science Foundation (INSF)/
GR  - 4694/Shahid Sadoughi University of Medical Sciences/
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190901
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Blood Glucose)
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Composition
MH  - Diabetes Mellitus, Type 2/*drug therapy
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Resveratrol/pharmacology/*therapeutic use
MH  - Risk Factors
OTO - NOTNLM
OT  - blood glucose
OT  - body composition
OT  - resveratrol
OT  - type 2 diabetes mellitus
EDAT- 2019/09/03 06:00
MHDA- 2020/02/23 06:00
CRDT- 2019/09/03 06:00
PHST- 2019/04/19 00:00 [received]
PHST- 2019/07/28 00:00 [revised]
PHST- 2019/08/06 00:00 [accepted]
PHST- 2019/09/03 06:00 [pubmed]
PHST- 2020/02/23 06:00 [medline]
PHST- 2019/09/03 06:00 [entrez]
AID - 10.1002/ptr.6487 [doi]
PST - ppublish
SO  - Phytother Res. 2019 Dec;33(12):3153-3162. doi: 10.1002/ptr.6487. Epub 2019 Sep 1.