PMID- 31475794 OWN - NLM STAT- MEDLINE DCOM- 20191106 LR - 20211204 IS - 1533-4406 (Electronic) IS - 0028-4793 (Linking) VI - 381 IP - 17 DP - 2019 Oct 24 TI - Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction. PG - 1609-1620 LID - 10.1056/NEJMoa1908655 [doi] AB - BACKGROUND: The angiotensin receptor-neprilysin inhibitor sacubitril-valsartan led to a reduced risk of hospitalization for heart failure or death from cardiovascular causes among patients with heart failure and reduced ejection fraction. The effect of angiotensin receptor-neprilysin inhibition in patients with heart failure with preserved ejection fraction is unclear. METHODS: We randomly assigned 4822 patients with New York Heart Association (NYHA) class II to IV heart failure, ejection fraction of 45% or higher, elevated level of natriuretic peptides, and structural heart disease to receive sacubitril-valsartan (target dose, 97 mg of sacubitril with 103 mg of valsartan twice daily) or valsartan (target dose, 160 mg twice daily). The primary outcome was a composite of total hospitalizations for heart failure and death from cardiovascular causes. Primary outcome components, secondary outcomes (including NYHA class change, worsening renal function, and change in Kansas City Cardiomyopathy Questionnaire [KCCQ] clinical summary score [scale, 0 to 100, with higher scores indicating fewer symptoms and physical limitations]), and safety were also assessed. RESULTS: There were 894 primary events in 526 patients in the sacubitril-valsartan group and 1009 primary events in 557 patients in the valsartan group (rate ratio, 0.87; 95% confidence interval [CI], 0.75 to 1.01; P = 0.06). The incidence of death from cardiovascular causes was 8.5% in the sacubitril-valsartan group and 8.9% in the valsartan group (hazard ratio, 0.95; 95% CI, 0.79 to 1.16); there were 690 and 797 total hospitalizations for heart failure, respectively (rate ratio, 0.85; 95% CI, 0.72 to 1.00). NYHA class improved in 15.0% of the patients in the sacubitril-valsartan group and in 12.6% of those in the valsartan group (odds ratio, 1.45; 95% CI, 1.13 to 1.86); renal function worsened in 1.4% and 2.7%, respectively (hazard ratio, 0.50; 95% CI, 0.33 to 0.77). The mean change in the KCCQ clinical summary score at 8 months was 1.0 point (95% CI, 0.0 to 2.1) higher in the sacubitril-valsartan group. Patients in the sacubitril-valsartan group had a higher incidence of hypotension and angioedema and a lower incidence of hyperkalemia. Among 12 prespecified subgroups, there was suggestion of heterogeneity with possible benefit with sacubitril-valsartan in patients with lower ejection fraction and in women. CONCLUSIONS: Sacubitril-valsartan did not result in a significantly lower rate of total hospitalizations for heart failure and death from cardiovascular causes among patients with heart failure and an ejection fraction of 45% or higher. (Funded by Novartis; PARAGON-HF ClinicalTrials.gov number, NCT01920711.). CI - Copyright (c) 2019 Massachusetts Medical Society. FAU - Solomon, Scott D AU - Solomon SD AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - McMurray, John J V AU - McMurray JJV AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Anand, Inder S AU - Anand IS AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Ge, Junbo AU - Ge J AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Lam, Carolyn S P AU - Lam CSP AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Maggioni, Aldo P AU - Maggioni AP AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Martinez, Felipe AU - Martinez F AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Packer, Milton AU - Packer M AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Pfeffer, Marc A AU - Pfeffer MA AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Pieske, Burkert AU - Pieske B AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Redfield, Margaret M AU - Redfield MM AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Rouleau, Jean L AU - Rouleau JL AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - van Veldhuisen, Dirk J AU - van Veldhuisen DJ AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Zannad, Faiez AU - Zannad F AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Zile, Michael R AU - Zile MR AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Desai, Akshay S AU - Desai AS AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Claggett, Brian AU - Claggett B AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Jhund, Pardeep S AU - Jhund PS AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Boytsov, Sergey A AU - Boytsov SA AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Comin-Colet, Josep AU - Comin-Colet J AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Cleland, John AU - Cleland J AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Dungen, Hans-Dirk AU - Dungen HD AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Goncalvesova, Eva AU - Goncalvesova E AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Katova, Tzvetana AU - Katova T AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Kerr Saraiva, Jose F AU - Kerr Saraiva JF AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Lelonek, Malgorzata AU - Lelonek M AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Merkely, Bela AU - Merkely B AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Senni, Michele AU - Senni M AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Shah, Sanjiv J AU - Shah SJ AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Zhou, Jingmin AU - Zhou J AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Rizkala, Adel R AU - Rizkala AR AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Gong, Jianjian AU - Gong J AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Shi, Victor C AU - Shi VC AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). FAU - Lefkowitz, Martin P AU - Lefkowitz MP AD - From the Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston (S.D.S., M.A.P., A.S.D., B.C.); the British Heart Foundation Cardiovascular Research Centre (J.J.V.M., P.S.J.) and the Robertson Centre for Biostatistics and Clinical Trials, Institute of Health and Well-being (J.C.), University of Glasgow, Glasgow, and the National Heart and Lung Institute, Royal Brompton and Harefield Hospitals, Imperial College, London (J.C.) - all in the United Kingdom; University of Minnesota, Minneapolis (I.S.A), and Mayo Clinic, Rochester (M.M.R.) - both in Minnesota; Shanghai Institute of Cardiovascular Diseases (J. Ge) and the Department of Cardiology (J.Z.), Zhongshan Hospital, Fudan University, Shanghai, China; National Heart Center Singapore and Duke-National University of Singapore, Singapore (C.S.P.L); National Association of Hospital Cardiologists Research Center, Florence (A.P.M.), and the Cardiology Division, Cardiovascular Department, Hospital Papa Giovanni XXIII, Bergamo (M.S.) - both in Italy; National University of Cordoba, Cordoba, Argentina (F.M.); Baylor University Medical Center, Dallas (M.P.); the Department of Internal Medicine and Cardiology, German Center for Cardiovascular Research partner site Berlin (B.P.), and the Department of Cardiology, Charite Universitatsmedizin, Campus Virchow-Klinikum (H.-D.D.) - both in Berlin; Institut de Cardiologie de Montreal, Universite de Montreal, Montreal (J.L.R.); the Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (D.J.V.); INSERM Centre d'Investigation Clinic 1433 and Universite de Lorraine, Centre Hospitalier Regional et Universitaire, Nancy, France (F.Z.); Medical University of South Carolina and the Ralph H. Johnson Department of Veterans Affairs Medical Center, Charleston (M.R.Z.); National Research Center for Cardiology of the Ministry of Health of the Russian Federation, Moscow (S.A.B.); Community Heart Failure Program, Department of Cardiology, Bellvitge University Hospital and Bellvitge Institute for Biomedical Research, University of Barcelona, Barcelona (J.C.-C.); Department of Heart Failure-Transplantation, National Cardiovascular Institute, Bratislava, Slovakia (E.G.); Clinic of Cardiology, National Cardiology Hospital, Sofia, Bulgaria (T.K.); Disciplina de Cardiologia Faculdade de Medicina Pontificia Universidade Catolica de Campinas, Sao Paulo (J.F.K.S.); the Department of Noninvasive Cardiology, Medical University of Lodz, Lodz, Poland (M.L.); Heart and Vascular Center, Semmelweis University, Budapest, Hungary (B.M.); Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago (S.J.S); and Novartis Pharmaceuticals, East Hanover, NJ (A.R.R., J. Gong, V.C.S., M.P.L.). CN - PARAGON-HF Investigators and Committees LA - eng SI - ClinicalTrials.gov/NCT01920711 PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20190901 PL - United States TA - N Engl J Med JT - The New England journal of medicine JID - 0255562 RN - 0 (Aminobutyrates) RN - 0 (Angiotensin Receptor Antagonists) RN - 0 (Biphenyl Compounds) RN - 0 (Drug Combinations) RN - 0 (Tetrazoles) RN - 80M03YXJ7I (Valsartan) RN - EC 3.4.24.11 (Neprilysin) RN - WB8FT61183 (sacubitril and valsartan sodium hydrate drug combination) SB - IM CIN - Nat Rev Cardiol. 2019 Nov;16(11):647. PMID: 31527744 CIN - N Engl J Med. 2019 Oct 24;381(17):1675-1676. PMID: 31644849 CIN - N Engl J Med. 2020 Mar 19;382(12):1180. PMID: 32187476 CIN - N Engl J Med. 2020 Mar 19;382(12):1180-1181. PMID: 32187477 CIN - N Engl J Med. 2020 Mar 19;382(12):1181. PMID: 32187478 CIN - N Engl J Med. 2020 Mar 19;382(12):1181-1182. PMID: 32187479 CIN - N Engl J Med. 2020 Mar 19;382(12):1182. PMID: 32187480 MH - Aged MH - Aminobutyrates/*administration & dosage/adverse effects MH - Angioedema/chemically induced MH - Angiotensin Receptor Antagonists/*administration & dosage/adverse effects MH - Biphenyl Compounds MH - Cardiovascular Diseases/*mortality MH - Double-Blind Method MH - Drug Combinations MH - Female MH - Follow-Up Studies MH - Heart Failure/*drug therapy/physiopathology MH - Hospitalization/*statistics & numerical data MH - Humans MH - Hypotension/chemically induced MH - Male MH - Middle Aged MH - Neprilysin/*antagonists & inhibitors MH - Quality of Life MH - Sex Factors MH - Single-Blind Method MH - Stroke Volume MH - Tetrazoles/*administration & dosage/adverse effects MH - Valsartan/*administration & dosage/adverse effects FIR - Perrone, S IR - Perrone S FIR - Albisu, J IR - Albisu J FIR - Avaca, H IR - Avaca H FIR - Chacon, C IR - Chacon C FIR - Cursack, G IR - Cursack G FIR - Diez, M IR - Diez M FIR - Duarte, A IR - Duarte A FIR - Fernandez, A IR - Fernandez A FIR - Gabito, A IR - Gabito A FIR - Gitelman, P IR - Gitelman P FIR - Hominal, M IR - Hominal M FIR - Leon de la Fuente, R IR - Leon de la Fuente R FIR - Llanos, J IR - Llanos J FIR - Majul, C IR - Majul C FIR - Mercau, G IR - Mercau G FIR - Moises Azize, G IR - Moises Azize G FIR - Montana, O IR - Montana O FIR - Perez Manghi, F IR - Perez Manghi F FIR - Poy, C IR - Poy C FIR - Prado, A IR - Prado A FIR - Ramos, H IR - Ramos H FIR - Resk, J IR - Resk J FIR - Scaro, G IR - Scaro G FIR - Schiavi, L IR - Schiavi L FIR - Soler, J IR - Soler J FIR - Vogelmann, O IR - Vogelmann O FIR - Wenetz, L IR - Wenetz L FIR - Zaidman, C IR - Zaidman C FIR - Anavekar, N IR - Anavekar N FIR - Amerena, J IR - Amerena J FIR - Cross, D IR - Cross D FIR - De Pasquale, C IR - De Pasquale C FIR - Eccleston, D IR - Eccleston D FIR - Howes, L IR - Howes L FIR - William, M IR - William M FIR - Zweiker, R IR - Zweiker R FIR - Adlbrecht, C IR - Adlbrecht C FIR - Altenberger, J IR - Altenberger J FIR - Auer, J IR - Auer J FIR - Bonderman, D IR - Bonderman D FIR - Siostrzonek, P IR - Siostrzonek P FIR - Weihs, W IR - Weihs W FIR - Zaruba, M IR - Zaruba M FIR - Janssens, S IR - Janssens S FIR - Derthoo, D IR - Derthoo D FIR - Hollanders, G IR - Hollanders G FIR - Maamar, R IR - Maamar R FIR - Mullens, W IR - Mullens W FIR - Pirenne, B IR - Pirenne B FIR - Pouleur, A IR - Pouleur A FIR - Smolders, W IR - Smolders W FIR - Timmermans, P IR - Timmermans P FIR - Vandekerckhove, H IR - Vandekerckhove H FIR - Verstreken, S IR - Verstreken S FIR - Wollaert, B IR - Wollaert B FIR - Kerr Saraiva, J F IR - Kerr Saraiva JF FIR - Abib Junior, E IR - Abib Junior E FIR - Beck-da-Silva, L IR - Beck-da-Silva L FIR - Arantes, F B IR - Arantes FB FIR - Cardoso, J IR - Cardoso J FIR - Kormann, A P IR - Kormann AP FIR - Lopes, H F IR - Lopes HF FIR - Maia, L N IR - Maia LN FIR - Manenti, E IR - Manenti E FIR - Precoma, D B IR - Precoma DB FIR - Rassi, S IR - Rassi S FIR - Reis, G IR - Reis G FIR - Rossi, P IR - Rossi P FIR - Simoes, M V IR - Simoes MV FIR - Katova, T IR - Katova T FIR - Benov, H IR - Benov H FIR - Chobanska, P IR - Chobanska P FIR - Chompalova, B IR - Chompalova B FIR - Denchev, S IR - Denchev S FIR - Dimov, B IR - Dimov B FIR - Dotcheva, E IR - Dotcheva E FIR - Gelev, V IR - Gelev V FIR - Genova, D IR - Genova D FIR - Georgiev, P IR - Georgiev P FIR - Kanazirev, B IR - Kanazirev B FIR - Kichukov, K IR - Kichukov K FIR - Kinova, E IR - Kinova E FIR - Lazov, P IR - Lazov P FIR - Mincheva Kabakchieva, V IR - Mincheva Kabakchieva V FIR - Shehova-Iankova, N IR - Shehova-Iankova N FIR - Srachkova-Aleksieva, A IR - Srachkova-Aleksieva A FIR - Syulemezova, S IR - Syulemezova S FIR - Tisheva-Gospodinova, S IR - Tisheva-Gospodinova S FIR - Todorov, G IR - Todorov G FIR - Tokmakova, M IR - Tokmakova M FIR - Tzekova, M IR - Tzekova M FIR - Valchanova, P IR - Valchanova P FIR - Yotov, Y IR - Yotov Y FIR - Zlateva, V IR - Zlateva V FIR - O'Meara, E IR - O'Meara E FIR - Bergeron, S IR - Bergeron S FIR - Coutu, B IR - Coutu B FIR - Demers, C IR - Demers C FIR - Diaz, A IR - Diaz A FIR - Howlett, J IR - Howlett J FIR - Huynh, T IR - Huynh T FIR - Lauzon, C IR - Lauzon C FIR - Lepage, S IR - Lepage S FIR - Michel, C IR - Michel C FIR - Mielniczuk, L M IR - Mielniczuk LM FIR - Moe, G IR - Moe G FIR - O'Connor, K IR - O'Connor K FIR - Pandey, S IR - Pandey S FIR - Parker, J IR - Parker J FIR - Rajda, M IR - Rajda M FIR - Robinson, S IR - Robinson S FIR - Sussex, B IR - Sussex B FIR - Udell, J IR - Udell J FIR - Yao, L IR - Yao L FIR - Zhou, J IR - Zhou J FIR - Chen, J IR - Chen J FIR - Chen, Y IR - Chen Y FIR - Chen, X IR - Chen X FIR - Ding, W IR - Ding W FIR - Dong, Y IR - Dong Y FIR - Fu, G IR - Fu G FIR - Huang, L IR - Huang L FIR - Ji, X IR - Ji X FIR - Jiang, T IR - Jiang T FIR - Ke, Y IR - Ke Y FIR - Kong, X IR - Kong X FIR - Li, D IR - Li D FIR - Li, H IR - Li H FIR - Li, Y IR - Li Y FIR - Li, Z IR - Li Z FIR - Liu, L IR - Liu L FIR - Liu, S IR - Liu S FIR - Liu, X IR - Liu X FIR - Liu, X IR - Liu X FIR - Ma, G IR - Ma G FIR - Mahemuti, A IR - Mahemuti A FIR - Miao, P IR - Miao P FIR - Su, H IR - Su H FIR - Sun, N IR - Sun N FIR - Sun, Z IR - Sun Z FIR - Tang, H IR - Tang H FIR - Tao, L IR - Tao L FIR - Wang, J IR - Wang J FIR - Xu, D IR - Xu D FIR - Xu, J IR - Xu J FIR - Xu, X IR - Xu X FIR - Yan, J IR - Yan J FIR - Yan, X IR - Yan X FIR - Yang, K IR - Yang K FIR - Yao, Z IR - Yao Z FIR - Yin, Y IR - Yin Y FIR - Yu, J IR - Yu J FIR - Yuan, Z IR - Yuan Z FIR - Zhang, J IR - Zhang J FIR - Zhang, R IR - Zhang R FIR - Zhao, Q IR - Zhao Q FIR - Zheng, Y IR - Zheng Y FIR - Echeverria, L E IR - Echeverria LE FIR - Accini, J IR - Accini J FIR - Cadena, A IR - Cadena A FIR - Lopez, M IR - Lopez M FIR - Saldarriaga, C IR - Saldarriaga C FIR - Urina, M IR - Urina M FIR - Milicic, D IR - Milicic D FIR - Busic, N IR - Busic N FIR - Car, S IR - Car S FIR - Cikes, M IR - Cikes M FIR - Knezevic, A IR - Knezevic A FIR - Sikic, J IR - Sikic J FIR - Vlahovic Palcevski, V IR - Vlahovic Palcevski V FIR - Widimsky, J Jr IR - 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Schou, M IR - Schou M FIR - Taurio, J IR - Taurio J FIR - Huikuri, H IR - Huikuri H FIR - Kiilavuori, K IR - Kiilavuori K FIR - Vanttinen, E IR - Vanttinen E FIR - Galinier, M IR - Galinier M FIR - Aupetit, J IR - Aupetit J FIR - Berdague, P IR - Berdague P FIR - Berthelot, E IR - Berthelot E FIR - Decoulx, E IR - Decoulx E FIR - Donal, E IR - Donal E FIR - Girerd, N IR - Girerd N FIR - Gosse, P IR - Gosse P FIR - Hrynchyshyn, N IR - Hrynchyshyn N FIR - Jourdain, P IR - Jourdain P FIR - Labeque, J IR - Labeque J FIR - Lefebvre, J IR - Lefebvre J FIR - Lequeux, B IR - Lequeux B FIR - Logeart, D IR - Logeart D FIR - Neuder, Y IR - Neuder Y FIR - Roubille, F IR - Roubille F FIR - Salvat, M IR - Salvat M FIR - Seronde, M IR - Seronde M FIR - Anker, S D IR - Anker SD FIR - Duengen, H D IR - Duengen HD FIR - Al-Zoebi, A IR - Al-Zoebi A FIR - Appel, K-F IR - Appel KF FIR - Auch-Schwelk, W IR - Auch-Schwelk W FIR - Axthelm, C IR - Axthelm C FIR - Baar, M IR - Baar M FIR - Baeumer, A IR - Baeumer A FIR - Bergmann, M IR - Bergmann M FIR - Beyer-Westendorf, J IR - Beyer-Westendorf J FIR - Birkemeyer, R IR - Birkemeyer R FIR - Birkenfeld, A IR - Birkenfeld A FIR - Boehm, M IR - Boehm M FIR - Bosiljanoff, P IR - Bosiljanoff P FIR - Bott, J IR - Bott J FIR - Brandenburg, V IR - Brandenburg V FIR - Diemert, P IR - Diemert P FIR - Donaubauer, T IR - Donaubauer T FIR - Duvinage, A IR - Duvinage A FIR - Ebert, H IR - Ebert H FIR - Faghih, M IR - Faghih M FIR - Fechtrup, C IR - Fechtrup C FIR - Gerbaulet, U IR - Gerbaulet U FIR - Ghanem, A IR - Ghanem A FIR - Goeller, V IR - Goeller V FIR - Haas, J IR - Haas J FIR - Hagenow, A IR - Hagenow A FIR - Hegemann, P IR - Hegemann P FIR - Horacek, T IR - Horacek T FIR - Ince, H IR - Ince H FIR - Jerwan-Keim, R IR - Jerwan-Keim R FIR - Jungmair, W IR - Jungmair W FIR - Kadel, C IR - Kadel C FIR - Kasner, M IR - Kasner M FIR - Killat, H IR - Killat H FIR - Konstas, C IR - Konstas C FIR - Krueger, U IR - Krueger U FIR - Lehmann, H IR - Lehmann H FIR - Leicht, M IR - Leicht M FIR - Loebe, M IR - Loebe M FIR - Maas, M IR - Maas M FIR - Mehling, H IR - Mehling H FIR - Menzel, F IR - Menzel F FIR - Naudts, I IR - Naudts I FIR - Naumann, R IR - Naumann R FIR - Noutsias, M IR - Noutsias M FIR - Overhoff, U IR - Overhoff U FIR - Proepper, F IR - Proepper F FIR - Prohaska, M IR - Prohaska M FIR - Proskynitopoulos, N IR - Proskynitopoulos N FIR - Rieker, W IR - Rieker W FIR - Rummel, R IR - Rummel R FIR - Salbach, P IR - Salbach P FIR - Sarnighausen, H IR - Sarnighausen H FIR - Schiffer, C IR - Schiffer C FIR - Schindler, A IR - Schindler A FIR - Schmitt, B IR - Schmitt B FIR - Schnabel, A IR - Schnabel A FIR - Schoen, N IR - Schoen N FIR - Schreckenberg, A IR - Schreckenberg A FIR - Schroeder, T IR - Schroeder T FIR - Schuett, K IR - Schuett K FIR - Schulze, U IR - Schulze U FIR - Seidel, M IR - Seidel M FIR - Simonis, G IR - Simonis G FIR - Stellmach, H IR - Stellmach H FIR - Stoerk, S IR - Stoerk S FIR - Stypmann, J IR - Stypmann J FIR - Suselbeck, T IR - Suselbeck T FIR - Taggeselle, J IR - Taggeselle J FIR - Tamm, A IR - Tamm A FIR - Tuletta, I IR - Tuletta I FIR - Ujeyl, A IR - Ujeyl A FIR - Weimer, J IR - Weimer J FIR - Westermann, D IR - Westermann D FIR - Westphal, J IR - Westphal J FIR - Wichterich, K IR - Wichterich K FIR - Wilke, A IR - Wilke A FIR - Winkelmann, B IR - Winkelmann B FIR - Zeh, W IR - Zeh W FIR - Filippatos, G IR - Filippatos G FIR - Giamouzis, G IR - Giamouzis G FIR - Karvounis, C IR - Karvounis C FIR - Naka, A IR - Naka A FIR - Patsilinakos, S IR - Patsilinakos S FIR - Petropoulou, E IR - Petropoulou E FIR - Tsioufis, K IR - Tsioufis K FIR - Vassilikos, V IR - Vassilikos V FIR - Arango, J L IR - Arango JL FIR - Chang, C IR - Chang C FIR - Corona, V IR - Corona V FIR - Guzman, I IR - Guzman I FIR - Herrera, L IR - Herrera L FIR - Lopez, E IR - Lopez E FIR - Ovando, A IR - Ovando A FIR - Paniagua, V IR - Paniagua V FIR - Vogel, M IR - Vogel M FIR - Merkely, B IR - Merkely B FIR - Andreka, P IR - Andreka P FIR - Hajko, E IR - Hajko E FIR - Kalina, A IR - Kalina A FIR - Kirschner, R IR - Kirschner R FIR - Lupkovics, G IR - Lupkovics G FIR - Nagy, A IR - Nagy A FIR - Noori, E IR - Noori E FIR - Nyolczas, N IR - Nyolczas N FIR - Palinkas, A IR - Palinkas A FIR - Sarszegi, Z IR - Sarszegi Z FIR - Szocs, A IR - Szocs A FIR - Toth, K IR - Toth K FIR - Varga, A IR - Varga A FIR - Varga, N IR - Varga N FIR - Zilahi, Z IR - Zilahi Z FIR - Kumar Chopra, V IR - Kumar Chopra V FIR - Agarwal, D IR - Agarwal D FIR - Aggarwal, R IR - Aggarwal R FIR - Dobariya, H IR - Dobariya H FIR - Hardas, S IR - Hardas S FIR - Kashyap, J IR - Kashyap J FIR - Kumar, R IR - Kumar R FIR - Mehta, A IR - Mehta A FIR - Menon, J IR - Menon J FIR - Mullasari, A IR - Mullasari A FIR - Oomman, A IR - Oomman A FIR - Prakash, D IR - Prakash D FIR - Rastogi, V IR - Rastogi V FIR - Sarma, R IR - Sarma R FIR - Sethuraman, S IR - Sethuraman S FIR - Shah, J IR - Shah J FIR - Sinha, D IR - Sinha D FIR - Ben-Gal, T IR - Ben-Gal T FIR - Amir, O IR - Amir O FIR - Atar, S IR - Atar S FIR - Bental, T IR - Bental T FIR - Dobrecky-Mary, I IR - Dobrecky-Mary I FIR - Freimark, D IR - Freimark D FIR - Goland, S IR - Goland S FIR - Kinany, W IR - Kinany W FIR - Kleiner Shochat, M IR - Kleiner Shochat M FIR - Menachemi, D IR - Menachemi D FIR - Rispler, S IR - Rispler S FIR - Rosenschein, U IR - Rosenschein U FIR - Senni, M IR - Senni M FIR - Agnelli, G IR - Agnelli G FIR - Argiolas, G IR - Argiolas G FIR - Baldin, M IR - Baldin M FIR - Bonanni, L IR - Bonanni L FIR - Borghi, C IR - Borghi C FIR - Campana, C IR - Campana C FIR - Carluccio, E IR - Carluccio E FIR - Cosmi, F IR - Cosmi F FIR - Di Lenarda, A IR - Di Lenarda A FIR - Dognini, G IR - Dognini G FIR - Fucili, A IR - Fucili A FIR - Giannattasio, C IR - Giannattasio C FIR - Gianonatti, C IR - Gianonatti C FIR - Gori, M IR - Gori M FIR - Imberti, D IR - Imberti D FIR - Lembo, G IR - Lembo G FIR - Midi, P IR - Midi P FIR - Mortara, A IR - Mortara A FIR - Mos, L IR - Mos L FIR - Muiesan, M IR - Muiesan M FIR - Nassiacos, D IR - Nassiacos D FIR - Parati, G IR - Parati G FIR - Pirisi, M IR - Pirisi M FIR - Raineri, C IR - Raineri C FIR - Rossi, G IR - Rossi G FIR - Sinagra, G IR - Sinagra G FIR - Trimarco, B IR - Trimarco B FIR - Versace, A IR - Versace A FIR - Vighi, G IR - Vighi G FIR - Volpe, M IR - Volpe M FIR - Volterrani, M IR - Volterrani M FIR - Saito, Y IR - Saito Y FIR - Asano, H IR - Asano H FIR - Doi, M IR - Doi M FIR - Ebato, M IR - Ebato M FIR - Fukui, K IR - Fukui K FIR - Hata, Y IR - Hata Y FIR - Ishikawa, T IR - Ishikawa T FIR - Kadokami, T IR - Kadokami T FIR - Kobayashi, Y IR - Kobayashi Y FIR - Matsumoto, N IR - Matsumoto N FIR - Nakamura, A IR - Nakamura A FIR - Niinuma, H IR - Niinuma H FIR - Okumura, Y IR - Okumura Y FIR - Sakagami, S IR - Sakagami S FIR - Sato, Y IR - Sato Y FIR - Shibasaki, T IR - Shibasaki T FIR - Sugimura, K IR - Sugimura K FIR - Takaishi, A IR - Takaishi A FIR - Takama, N IR - Takama N FIR - Tsuboi, H IR - Tsuboi H FIR - Tsujiyama, S IR - Tsujiyama S FIR - Ueda, T IR - Ueda T FIR - Wada, A IR - Wada A FIR - Yagi, M IR - Yagi M FIR - Oh, B IR - Oh B FIR - Cho, H IR - Cho H FIR - Cho, M IR - Cho M FIR - Choi, D IR - Choi D FIR - Hong, S IR - Hong S FIR - Jeon, E IR - Jeon E FIR - Kang, S IR - Kang S FIR - Kim, E IR - Kim E FIR - Kim, J IR - Kim J FIR - Kim, K IR - Kim K FIR - Kwan, J IR - Kwan J FIR - Shim, W IR - Shim W FIR - Yoo, B IR - Yoo B FIR - Arenas, J L IR - Arenas JL FIR - Bayram, E IR - Bayram E FIR - Bazzoni, A IR - Bazzoni A FIR - Briseno, J IR - Briseno J FIR - Carrillo, J IR - Carrillo J FIR - De Los Rios, M IR - De Los Rios M FIR - Leon, S IR - Leon S FIR - Rodriguez, I IR - Rodriguez I FIR - Solache, G IR - Solache G FIR - Velasco, R IR - Velasco R FIR - Venegas, L IR - Venegas L FIR - Linssen, G IR - Linssen G FIR - Bellersen, L IR - Bellersen L FIR - Den Hartog, F IR - Den Hartog F FIR - Elvan, A IR - Elvan A FIR - Groenemeijer, B IR - Groenemeijer B FIR - Hermans, W IR - Hermans W FIR - Hoedemaker, G IR - Hoedemaker G FIR - Jansen, A IR - Jansen A FIR - Kaplan, R IR - Kaplan R FIR - Manintveld, O IR - Manintveld O FIR - Savalle, L IR - Savalle L FIR - Swart, H IR - Swart H FIR - van Alem, A IR - van Alem A FIR - van Beek, E IR - van Beek E FIR - van der Meer, P IR - van der Meer P FIR - Willems, F IR - Willems F FIR - Atar, D IR - Atar D FIR - Fosse, E IR - Fosse E FIR - Hall, C IR - Hall C FIR - Manhenke, C IR - Manhenke C FIR - Pervez, M IR - Pervez M FIR - Rosjo, H IR - Rosjo H FIR - von Lueder, T IR - von Lueder T FIR - Godoy, A IR - Godoy A FIR - Lema, J IR - Lema J FIR - Lu, L IR - Lu L FIR - Rodriguez, J IR - Rodriguez J FIR - Rodriguez, V IR - Rodriguez V FIR - Sibulo, A S Jr IR - Sibulo AS Jr FIR - Abola, M IR - Abola M FIR - Borromeo, A IR - Borromeo A FIR - Ferrolino, A IR - Ferrolino A FIR - Locnen, S IR - Locnen S FIR - Ongjoco, E IR - Ongjoco E FIR - Rosita, R IR - Rosita R FIR - Lelonek, M IR - Lelonek M FIR - Balsam, P IR - Balsam P FIR - Baska, J IR - Baska J FIR - Bednarski, J IR - Bednarski J FIR - Cymerman, K IR - Cymerman K FIR - Czochra, W IR - Czochra W FIR - Dudek, D IR - Dudek D FIR - Janik, A IR - Janik A FIR - Karas, P IR - Karas P FIR - Kolaczyk, P IR - Kolaczyk P FIR - Konieczny, M IR - Konieczny M FIR - Landa, K IR - Landa K FIR - Lysek, R IR - Lysek R FIR - Makowiecka-Ciesla, M IR - Makowiecka-Ciesla M FIR - Wojciechowska, C IR - Wojciechowska C FIR - Wozniak, I IR - Wozniak I FIR - Wronska, D IR - Wronska D FIR - Zielinska, E IR - Zielinska E FIR - Vinereanu, D IR - Vinereanu D FIR - Balan, C IR - Balan C FIR - Bartos, D IR - Bartos D FIR - Cindea Nica, N IR - Cindea Nica N FIR - Ciobotaru, G IR - Ciobotaru G FIR - Coman, S IR - Coman S FIR - Ioachim Popescu, M IR - Ioachim Popescu M FIR - Lighezan, D IR - Lighezan D FIR - Militaru, C IR - Militaru C FIR - Minescu, B IR - Minescu B FIR - Pescariu, S IR - Pescariu S FIR - Podoleanu, C IR - Podoleanu C FIR - Pop, C IR - Pop C FIR - Pop Moldovan, A IR - Pop Moldovan A FIR - Stanciulescu, G IR - Stanciulescu G FIR - Tomescu, M IR - Tomescu M FIR - Boytsov, S IR - Boytsov S FIR - Agafina, A IR - Agafina A FIR - Ageev, F IR - Ageev F FIR - Baranov, E IR - Baranov E FIR - Baranova, E IR - Baranova E FIR - Barbarash, O IR - Barbarash O FIR - Burova, N IR - Burova N FIR - Ershova, O IR - Ershova O FIR - Gorbacheva, I IR - Gorbacheva I FIR - Ivanov, I IR - Ivanov I FIR - Izmozherova, N IR - Izmozherova N FIR - Kastanayan, A IR - Kastanayan A FIR - Khaisheva, L IR - Khaisheva L FIR - Khromtsova, O IR - Khromtsova O FIR - Kitsyshin, V IR - Kitsyshin V FIR - Kobalava, Z IR - Kobalava Z FIR - Konradi, A IR - Konradi A FIR - Koziolova, N IR - Koziolova N FIR - Malchikova, S IR - Malchikova S FIR - Maximov, N IR - Maximov N FIR - Myasnikov, R IR - Myasnikov R FIR - Pimenov, L IR - Pimenov L FIR - Polezhaeva, N IR - Polezhaeva N FIR - Privalov, D IR - Privalov D FIR - Rafalskiy, V IR - Rafalskiy V FIR - Shutemova, E IR - Shutemova E FIR - Shvarts, Y IR - Shvarts Y FIR - Solovev, O IR - Solovev O FIR - Tarasov, N IR - Tarasov N FIR - Tereschenko, S IR - Tereschenko S FIR - Treshkur, T IR - Treshkur T FIR - Uspenskiy, Y IR - Uspenskiy Y FIR - Zrazhevsky, K IR - Zrazhevsky K FIR - Seferovic, P IR - Seferovic P FIR - Apostolovic, S IR - Apostolovic S FIR - Boskovic, S IR - Boskovic S FIR - Deljanin-Ilic, M IR - Deljanin-Ilic M FIR - Ristic, A IR - Ristic A FIR - Sim Kheng Leng, D IR - Sim Kheng Leng D FIR - Lee, C W IR - Lee CW FIR - Lee, S G S IR - Lee SGS FIR - Leong, K T G IR - Leong KTG FIR - Loh, S Y IR - Loh SY FIR - Min Er, C IR - Min Er C FIR - Ong, H Y IR - Ong HY FIR - Wenjie, H IR - Wenjie H FIR - Soon, D K N IR - Soon DKN FIR - Wong, R C IR - Wong RC FIR - Goncalvesova, E IR - Goncalvesova E FIR - Antalik, L IR - Antalik L FIR - Benacka, J IR - Benacka J FIR - Bugan, V IR - Bugan V FIR - Dulkova, K IR - Dulkova K FIR - Dzupina, A IR - Dzupina A FIR - Fulop, P IR - Fulop P FIR - Gergel, V IR - Gergel V FIR - Gergely, P IR - Gergely P FIR - Gonsorcik, J IR - Gonsorcik J FIR - Kabaivanov, P IR - Kabaivanov P FIR - Klabnik, A IR - Klabnik A FIR - Kohlerova, E IR - Kohlerova E FIR - Kolikova, V IR - Kolikova V FIR - Majercak, I IR - Majercak I FIR - Mancikova, I IR - Mancikova I FIR - Mihalikova, A IR - Mihalikova A FIR - Nociar, J IR - Nociar J FIR - Pacherova, J IR - Pacherova J FIR - Palka, J IR - Palka J FIR - Radomska, M IR - Radomska M FIR - Sabo, L IR - Sabo L FIR - Schichorova, J IR - Schichorova J FIR - Smik, R IR - Smik R FIR - Sokolova, B IR - Sokolova B FIR - Stofkova, D IR - Stofkova D FIR - Strbova, J IR - Strbova J FIR - Toth, P IR - Toth P FIR - Urgeova, L IR - Urgeova L FIR - Vinanska, D IR - Vinanska D FIR - Vrtovec, B IR - Vrtovec B FIR - Marcun, R IR - Marcun R FIR - Ranjith, N IR - Ranjith N FIR - Badat, A IR - Badat A FIR - Burgess, L IR - Burgess L FIR - DeVries Basson, M M IR - DeVries Basson MM FIR - Fourie, N IR - Fourie N FIR - Hellstrom, E IR - Hellstrom E FIR - Kapp, C IR - Kapp C FIR - Latiff, G IR - Latiff G FIR - Makotoko, E IR - Makotoko E FIR - Manga, P IR - Manga P FIR - Moodley, R IR - Moodley R FIR - Ntsekhe, M IR - Ntsekhe M FIR - Oosthuysen, W IR - Oosthuysen W FIR - Roos, J IR - Roos J FIR - Theron, H IR - Theron H FIR - Thomas, K IR - Thomas K FIR - van Zyl, L IR - van Zyl L FIR - Comin Colet, J IR - Comin Colet J FIR - Almenar Bonet, L IR - Almenar Bonet L FIR - Bayes Genis, A IR - Bayes Genis A FIR - Bayon Fernandez, J IR - Bayon Fernandez J FIR - Bover Freire, J IR - Bover Freire J FIR - Calvo Gomez, C IR - Calvo Gomez C FIR - Esteban, A IR - Esteban A FIR - Elvira Gonzalez, J IR - Elvira Gonzalez J FIR - Farre Lopez, N IR - Farre Lopez N FIR - Freixa Pamies, R IR - Freixa Pamies R FIR - Garcia Aguado, M IR - Garcia Aguado M FIR - Garcia Del Rio, E IR - Garcia Del Rio E FIR - Garcia Pavia, P IR - Garcia Pavia P FIR - Garcia Pinilla, J IR - Garcia Pinilla J FIR - Garcia Puig, J IR - Garcia Puig J FIR - Gonzalez Juanatey, J IR - Gonzalez Juanatey J FIR - Gonzalez Vilchez, F IR - Gonzalez Vilchez F FIR - Llanos Lorente Aroca, M IR - Llanos Lorente Aroca M FIR - Manzano Espinosa, L IR - Manzano Espinosa L FIR - Marin, I IR - Marin I FIR - Martin Raymondi, D IR - Martin Raymondi D FIR - Martinez Selles, M IR - Martinez Selles M FIR - Marzal, D IR - Marzal D FIR - Montero Perez-Barquero, M IR - Montero Perez-Barquero M FIR - Nieto Iglesias, L IR - Nieto Iglesias L FIR - Nunez Villota, J IR - Nunez Villota J FIR - Pascual Figal, D IR - Pascual Figal D FIR - Pena Perez, G IR - Pena Perez G FIR - Perez Silvestre, J IR - Perez Silvestre J FIR - Quesada, A IR - Quesada A FIR - Reyes Dominguez, A IR - Reyes Dominguez A FIR - Silvestre, J IR - Silvestre J FIR - Torres Calvo, F IR - Torres Calvo F FIR - Vaello, A IR - Vaello A FIR - Trullas Vila, J IR - Trullas Vila J FIR - Vida, M IR - Vida M FIR - Worner Diz, F IR - Worner Diz F FIR - Lund, L H IR - Lund LH FIR - Almgren, T IR - Almgren T FIR - Bengtsson, M IR - Bengtsson M FIR - Berglund, S IR - Berglund S FIR - Floderer, E IR - Floderer E FIR - Lindholm, C J IR - Lindholm CJ FIR - Ostlund-Papadogeorgos, N IR - Ostlund-Papadogeorgos N FIR - Skoglund Andersson, C IR - Skoglund Andersson C FIR - Szabo, B IR - Szabo B FIR - Flammer, A IR - Flammer A FIR - Hullin, R IR - Hullin R FIR - Hunziker Munsch, L IR - Hunziker Munsch L FIR - Moccetti, T IR - Moccetti T FIR - Pfister, O IR - Pfister O FIR - Roethlisberger, C IR - Roethlisberger C FIR - Suter, T IR - Suter T FIR - Chen, C-H IR - Chen CH FIR - Chang, K C IR - Chang KC FIR - Chen, C P IR - Chen CP FIR - Chen, J Y IR - Chen JY FIR - Chen, Z C IR - Chen ZC FIR - Lin, J L IR - Lin JL FIR - Lin, T H IR - Lin TH FIR - Lin, L Y IR - Lin LY FIR - Tsao, H M IR - Tsao HM FIR - Wu, C K IR - Wu CK FIR - Wu, Y W IR - Wu YW FIR - Birhan Yilmaz, M IR - Birhan Yilmaz M FIR - Badak, O IR - Badak O FIR - Cincin, A IR - Cincin A FIR - Guvenc, T IR - Guvenc T FIR - Ongen, Z IR - Ongen Z FIR - Sahin, T IR - Sahin T FIR - Yavuzgil, O IR - Yavuzgil O FIR - Yigit, Z IR - Yigit Z FIR - Cleland, J IR - Cleland J FIR - Al-Mohammad, A IR - Al-Mohammad A FIR - Banerjee, P IR - Banerjee P FIR - Bethell, H IR - Bethell H FIR - Brown, N IR - Brown N FIR - Brunskill, J IR - Brunskill J FIR - Clark, A IR - Clark A FIR - Clifford, P IR - Clifford P FIR - Crawford, G IR - Crawford G FIR - Dayer, M IR - Dayer M FIR - Dewhurst, M IR - Dewhurst M FIR - Duckett, S IR - Duckett S FIR - Foley, P IR - Foley P FIR - Fuat, A IR - Fuat A FIR - Gardner, R IR - Gardner R FIR - Gaunt, R IR - Gaunt R FIR - Glover, J IR - Glover J FIR - Gordon, B IR - Gordon B FIR - Jhund, P IR - Jhund P FIR - Jones, R IR - Jones R FIR - Kalra, P IR - Kalra P FIR - Keeling, P IR - Keeling P FIR - Lang, C IR - Lang C FIR - Lawrance, R IR - Lawrance R FIR - Markwick, C IR - Markwick C FIR - McCormack, T IR - McCormack T FIR - McDonagh, T IR - McDonagh T FIR - McMurray, J IR - McMurray J FIR - Meleady, R IR - Meleady R FIR - Mohindra, R IR - Mohindra R FIR - Moriarty, A IR - Moriarty A FIR - Murphy, J IR - Murphy J FIR - Sobolewska, J IR - Sobolewska J FIR - Takhar, A IR - Takhar A FIR - Vazir, A IR - Vazir A FIR - Walsh, J IR - Walsh J FIR - Witherow, F IR - Witherow F FIR - Shah, S IR - Shah S FIR - Sweitzer, N IR - Sweitzer N FIR - Abbate, K IR - Abbate K FIR - Abraham, J IR - Abraham J FIR - Adams, K IR - Adams K FIR - Adler, A IR - Adler A FIR - Ariani, M IR - Ariani M FIR - Aslam, A IR - Aslam A FIR - Banerjee, S IR - Banerjee S FIR - Bellumkonda, L IR - Bellumkonda L FIR - Berk, M IR - Berk M FIR - Brown, C IR - Brown C FIR - Carr, K IR - Carr K FIR - Cavanaugh, B IR - Cavanaugh B FIR - Chambers, C IR - Chambers C FIR - Chandra, L IR - Chandra L FIR - Chen, Y IR - Chen Y FIR - Chung, E IR - Chung E FIR - Cimato, T IR - Cimato T FIR - Cogswell, R IR - Cogswell R FIR - Costanzo, M IR - Costanzo M FIR - Derian, W IR - Derian W FIR - Dharma, C IR - Dharma C FIR - Dhingra, R IR - Dhingra R FIR - Diggs, P IR - Diggs P FIR - Fattal, P IR - Fattal P FIR - Florea, V IR - Florea V FIR - Flores, E IR - Flores E FIR - Forgosh, L IR - Forgosh L FIR - Friedman, K IR - Friedman K FIR - Gardetto, N IR - Gardetto N FIR - Geltman, E IR - Geltman E FIR - Gianfagna, R IR - Gianfagna R FIR - Gillespie, E IR - Gillespie E FIR - Go, J IR - Go J FIR - Gogia, H IR - Gogia H FIR - Goldschmidt, M IR - Goldschmidt M FIR - Gopal, D IR - Gopal D FIR - Gordon, R IR - Gordon R FIR - Gorton, C IR - Gorton C FIR - Gredler, F IR - Gredler F FIR - Grena, P IR - Grena P FIR - Gupta, D IR - Gupta D FIR - Hankins, S IR - Hankins S FIR - Hargrove, J IR - Hargrove J FIR - Hart, T IR - Hart T FIR - Hattler, B IR - Hattler B FIR - Haught, H IR - Haught H FIR - Hedgepeth, C IR - Hedgepeth C FIR - Heilman, K J 3rd IR - Heilman KJ 3rd FIR - Heitner, J IR - Heitner J FIR - Heroux, A IR - Heroux A FIR - Hummel, S IR - Hummel S FIR - Ince, C IR - Ince C FIR - Iteld, B IR - Iteld B FIR - Jadbabaie, F IR - Jadbabaie F FIR - Jardula, M IR - Jardula M FIR - Jonsson, O IR - Jonsson O FIR - Joseph, J IR - Joseph J FIR - Joseph, S IR - Joseph S FIR - Kashani, A IR - Kashani A FIR - Khan, M IR - Khan M FIR - Kitzman, D IR - Kitzman D FIR - Kono, A IR - Kono A FIR - Kostis, W IR - Kostis W FIR - Krishnamoorthy, A IR - Krishnamoorthy A FIR - Lader, E IR - Lader E FIR - Lederman, S IR - Lederman S FIR - Leimbach, W IR - Leimbach W FIR - Lepor, N IR - Lepor N FIR - Lester, M IR - Lester M FIR - Levy, W IR - Levy W FIR - Lombardo, D IR - Lombardo D FIR - Long, R IR - Long R FIR - Lorber, D IR - Lorber D FIR - Lozano, J IR - Lozano J FIR - Mallis, G IR - Mallis G FIR - Mani, C K IR - Mani CK FIR - McLaurin, M IR - McLaurin M FIR - Mikdadi, G IR - Mikdadi G FIR - Mody, F IR - Mody F FIR - Monteleone, P IR - Monteleone P FIR - Moraes, D IR - Moraes D FIR - Murray, D IR - Murray D FIR - Murthy, S IR - Murthy S FIR - Onwuanyi, A IR - Onwuanyi A FIR - Ooi, H IR - Ooi H FIR - Palac, R IR - Palac R FIR - Pelzel, J IR - Pelzel J FIR - Petersen, J 2nd IR - Petersen J 2nd FIR - Phillips, R IR - Phillips R FIR - Pickett, C IR - Pickett C FIR - Pina, I IR - Pina I FIR - Portnay, E IR - Portnay E FIR - Prodafikas, J IR - Prodafikas J FIR - Rahmatullah, A IR - Rahmatullah A FIR - Rama, B IR - Rama B FIR - Ramanathan, K IR - Ramanathan K FIR - Reza, S IR - Reza S FIR - Ross, A IR - Ross A FIR - Ryan, J IR - Ryan J FIR - Sanchez, E IR - Sanchez E FIR - Sayer, G IR - Sayer G FIR - Schmalfuss, C IR - Schmalfuss C FIR - Schwartz, M IR - Schwartz M FIR - Selektor, Y IR - Selektor Y FIR - Shah, A IR - Shah A FIR - Shanes, J IR - Shanes J FIR - Sharma, K IR - Sharma K FIR - Sharma, S IR - Sharma S FIR - Singh, N IR - Singh N FIR - Sopko, K IR - Sopko K FIR - Sotolongo, R IR - Sotolongo R FIR - Steuter, J IR - Steuter J FIR - Stoddard, M IR - Stoddard M FIR - Sulemanjee, N IR - Sulemanjee N FIR - Tahir, M IR - Tahir M FIR - Thomas, S IR - Thomas S FIR - Thompson, C IR - Thompson C FIR - Treasure, C 2nd IR - Treasure C 2nd FIR - Valika, A IR - Valika A FIR - Vanhecke, T IR - Vanhecke T FIR - Vardeny, O IR - Vardeny O FIR - Watts, J IR - Watts J FIR - Wight, J IR - Wight J FIR - Yehya, A IR - Yehya A FIR - Zarate, J IR - Zarate J FIR - Zebrack, J IR - Zebrack J FIR - Zhang, L IR - Zhang L FIR - Zile, M IR - Zile M EDAT- 2019/09/03 06:00 MHDA- 2019/11/07 06:00 CRDT- 2019/09/03 06:00 PHST- 2019/09/03 06:00 [pubmed] PHST- 2019/11/07 06:00 [medline] PHST- 2019/09/03 06:00 [entrez] AID - 10.1056/NEJMoa1908655 [doi] PST - ppublish SO - N Engl J Med. 2019 Oct 24;381(17):1609-1620. doi: 10.1056/NEJMoa1908655. Epub 2019 Sep 1.