PMID- 31475889
OWN - NLM
STAT- MEDLINE
DCOM- 20210126
LR  - 20210126
IS  - 1875-533X (Electronic)
IS  - 0929-8673 (Linking)
VI  - 27
IP  - 39
DP  - 2020
TI  - The Role of Zinc and Copper in Insulin Resistance and Diabetes Mellitus.
PG  - 6643-6657
LID - 10.2174/0929867326666190902122155 [doi]
AB  - The prevalence of Type 2 Diabetes Mellitus (T2DM) is internationally 
      ever-growing. Therefore, prevention, diagnostics, and control of insulin 
      resistance and T2DM are of increasing importance. It has been suggested that 
      mechanisms leading to insulin resistance and diabetes and its complications 
      include high intake of refined and energy-rich food, which is presumed to be 
      accompanied by suboptimal intake of trace elements, such as Zinc (Zn), Selenium 
      (Se), Chromium (Cr), and Copper (Cu), which are essential and crucial for various 
      biological processes. The purpose of this review is to highlight the role of Zn, 
      Se, and Cu in T2DM. Diabetes seems prevalent when Zn, Se, and Cu are deficient, 
      which may result from excessive intake of refined food. The literature search was 
      conducted in PubMed and Scopus, supplemented with the reference lists of relevant 
      articles and a Google Scholar search. We critically assessed all relevant 
      citations, both review and research papers in English. The search terms that were 
      used included Zn, Cu, diabetes, and diabetes mellitus. Research has shown that 
      Zn, Se and Cu are involved in the pathogenesis of diabetes, but these trace 
      elements can in excessive amounts be toxic. Zinc appears to activate key 
      molecules that are involved in cell signaling, which maintain the homeostasis of 
      glucose. Zinc also regulates insulin receptors, prolong the action of insulin, 
      and promote healthy lipid profiles. Copper in excess can create oxidative stress, 
      which is a factor in the onset and the progression of T2DM. Abnormal Zn and Cu 
      metabolism appears to accompany and may also cause diabetes complications.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.net.
FAU - Bjorklund, Geir
AU  - Bjorklund G
AD  - Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
FAU - Dadar, Maryam
AU  - Dadar M
AD  - Razi Vaccine and Serum Research Institute, Agricultural Research, Education and 
      Extension Organization (AREEO), Karaj, Iran
FAU - Pivina, Lyudmila
AU  - Pivina L
AD  - Semey Medical University, Semey, Kazakhstan
AD  - CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical 
      University, Semey, Kazakhstan
FAU - Dosa, Monica Daniela
AU  - Dosa MD
AD  - Department of Pharmacology, Faculty of Medicine, Ovidius University, Constanta, 
      Romania
FAU - Semenova, Yuliya
AU  - Semenova Y
AD  - Semey Medical University, Semey, Kazakhstan
AD  - CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical 
      University, Semey, Kazakhstan
FAU - Aaseth, Jan
AU  - Aaseth J
AD  - Faculty of Health and Social Sciences, Inland Norway University of Applied 
      Sciences, Elverum, Norway
AD  - Department of Research, Innlandet Hospital Trust, Brumunddal, Norway
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 789U1901C5 (Copper)
RN  - H6241UJ22B (Selenium)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Copper
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - *Insulin Resistance
MH  - Selenium
MH  - Zinc
OTO - NOTNLM
OT  - Type 2 Diabetes Mellitus
OT  - Zinc
OT  - copper
OT  - diabetes mellitus
OT  - metals
OT  - trace elements
EDAT- 2019/09/03 06:00
MHDA- 2021/01/27 06:00
CRDT- 2019/09/03 06:00
PHST- 2019/05/01 00:00 [received]
PHST- 2019/07/30 00:00 [revised]
PHST- 2019/08/16 00:00 [accepted]
PHST- 2019/09/03 06:00 [pubmed]
PHST- 2021/01/27 06:00 [medline]
PHST- 2019/09/03 06:00 [entrez]
AID - CMC-EPUB-100573 [pii]
AID - 10.2174/0929867326666190902122155 [doi]
PST - ppublish
SO  - Curr Med Chem. 2020;27(39):6643-6657. doi: 10.2174/0929867326666190902122155.