PMID- 31476329
OWN - NLM
STAT- MEDLINE
DCOM- 20200709
LR  - 20200709
IS  - 1872-6216 (Electronic)
IS  - 0047-6374 (Linking)
VI  - 183
DP  - 2019 Oct
TI  - Regulation of cellular senescence by retinoid X receptors and their partners.
PG  - 111131
LID - S0047-6374(19)30136-8 [pii]
LID - 10.1016/j.mad.2019.111131 [doi]
AB  - Cellular senescence is a response characterized by a stable cell proliferation 
      arrest and a senescence-associated secretory phenotype (SASP) which can be 
      induced by many stresses, including telomere shortening and oncogene activation. 
      Senescence is crucially involved in a variety of physiopathological contexts, 
      such as cancer and aging. Given the fundamental role of this process, senescence 
      needs to be tightly regulated. In the last decade, the key implication of nuclear 
      receptors in cellular senescence has emerged. Here we will review the mechanisms 
      involved in the control of cellular senescence by retinoid X receptors (RXRs) and 
      their partners. We will also present our current knowledge on the regulation of 
      these receptors during senescence and on their potential role in 
      senescence-associated physiopathological conditions.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Martin, Nadine
AU  - Martin N
AD  - Centre de Recherche en Cancerologie de Lyon, Inserm U1052, CNRS UMR 5286, 
      Universite de Lyon, Centre Leon Berard, Lyon, France. Electronic address: 
      nadine.martin@lyon.unicancer.fr.
FAU - Ma, Xingjie
AU  - Ma X
AD  - Centre de Recherche en Cancerologie de Lyon, Inserm U1052, CNRS UMR 5286, 
      Universite de Lyon, Centre Leon Berard, Lyon, France.
FAU - Bernard, David
AU  - Bernard D
AD  - Centre de Recherche en Cancerologie de Lyon, Inserm U1052, CNRS UMR 5286, 
      Universite de Lyon, Centre Leon Berard, Lyon, France. Electronic address: 
      david.bernard@lyon.unicancer.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190830
PL  - Ireland
TA  - Mech Ageing Dev
JT  - Mechanisms of ageing and development
JID - 0347227
RN  - 0 (Retinoid X Receptors)
SB  - IM
MH  - Animals
MH  - *Cellular Senescence
MH  - Humans
MH  - Retinoid X Receptors/*metabolism
OTO - NOTNLM
OT  - Calcium
OT  - Nuclear receptors
OT  - RXR
OT  - Senescence
EDAT- 2019/09/03 06:00
MHDA- 2020/07/10 06:00
CRDT- 2019/09/03 06:00
PHST- 2019/03/04 00:00 [received]
PHST- 2019/06/20 00:00 [revised]
PHST- 2019/08/22 00:00 [accepted]
PHST- 2019/09/03 06:00 [pubmed]
PHST- 2020/07/10 06:00 [medline]
PHST- 2019/09/03 06:00 [entrez]
AID - S0047-6374(19)30136-8 [pii]
AID - 10.1016/j.mad.2019.111131 [doi]
PST - ppublish
SO  - Mech Ageing Dev. 2019 Oct;183:111131. doi: 10.1016/j.mad.2019.111131. Epub 2019 
      Aug 30.