PMID- 31477373 OWN - NLM STAT- MEDLINE DCOM- 20210118 LR - 20230211 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 215 DP - 2020 Jan TI - Cingulum bundle abnormalities and risk for schizophrenia. PG - 385-391 LID - S0920-9964(19)30358-5 [pii] LID - 10.1016/j.schres.2019.08.017 [doi] AB - BACKGROUND: The cingulum bundle (CB) is a major white matter fiber tract of the limbic system that underlies cingulate cortex, passing longitudinally over the corpus callosum. The connectivity of this white matter fiber tract plays a major role in emotional expression, attention, motivation, and working memory, all of which are affected in schizophrenia. Myelin related CB abnormalities have also been implicated in schizophrenia. The purpose of this study is to determine whether or not CB abnormalities are evident in individuals at clinical high risk (CHR) for psychosis, and whether or not cognitive deficits in the domains subserved by CB are related to its structural abnormalities. METHODS: Diffusion Tensor Imaging (DTI) was performed on a 3 T magnet. DT tractography was used to evaluate CB in 20 individuals meeting CHR criteria (13 males/7 females) and 23 healthy controls (12 males/11 females) group matched on age, gender, parental socioeconomic status, education, and handedness. Fractional anisotropy (FA), a measure of white matter coherence and integrity, radial diffusivity (RD), thought to reflect myelin integrity, trace, a possible marker of atrophy, and axial diffusivity (AD), thought to reflect axonal integrity, were averaged over the entire tract and used to investigate CB abnormalities in individuals at CHR for psychosis compared with healthy controls. RESULTS: Significant group differences were found between individuals at CHR for psychosis and controls for FA (p = 0.028), RD (p = 0.03) and trace (p = 0.031), but not for AD (p = 0.09). We did not find any significant correlations between DTI measures and clinical symptoms. CONCLUSION: These findings suggest abnormalities (possibly myelin related) in the CB in individuals at CHR for psychosis. CI - Copyright (c) 2019 Elsevier B.V. All rights reserved. FAU - Fitzsimmons, Jennifer AU - Fitzsimmons J AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. Electronic address: jfitzsimmons@bwh.harvard.edu. FAU - Rosa, Pedro AU - Rosa P AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Laboratory of Psychiatric Neuroimaging (LIM-21), Department & Institute of Psychiatry, Faculty of Medicine, Center of Interdisciplinary Research on Applied Neurosciences (NAPNA), University of Sao Paulo, Sao Paulo, Brazil; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. FAU - Sydnor, Valerie J AU - Sydnor VJ AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. FAU - Reid, Benjamin E AU - Reid BE AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. FAU - Makris, Nikos AU - Makris N AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. FAU - Goldstein, Jill M AU - Goldstein JM AD - Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States of America. FAU - Mesholam-Gately, Raquelle I AU - Mesholam-Gately RI AD - Beth Israel Deaconess Medical Center-Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States of America. FAU - Woodberry, Kristen AU - Woodberry K AD - Beth Israel Deaconess Medical Center-Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States of America. FAU - Wojcik, Joanne AU - Wojcik J AD - Beth Israel Deaconess Medical Center-Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States of America. FAU - McCarley, Robert W AU - McCarley RW AD - Department of Psychiatry, VA Boston Healthcare System, Harvard Medical School, Boston, MA, United States of America. FAU - Seidman, Larry J AU - Seidman LJ AD - Beth Israel Deaconess Medical Center-Massachusetts Mental Health Center, Public Psychiatry Division, Harvard Medical School, Boston, MA, United States of America; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America. FAU - Shenton, Martha E AU - Shenton ME AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Research and Development, VA Boston Healthcare System, Boston, MA, United States of America; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. FAU - Kubicki, Marek AU - Kubicki M AD - Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America; Psychiatry Neuroimaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America. LA - eng GR - T32 MH016259/MH/NIMH NIH HHS/United States GR - R01 MH102377/MH/NIMH NIH HHS/United States GR - R01 MH050740/MH/NIMH NIH HHS/United States GR - P50 MH080272/MH/NIMH NIH HHS/United States GR - K24 MH110807/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20190830 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Adolescent MH - Adult MH - Cognitive Dysfunction/diagnostic imaging/*pathology/physiopathology MH - Diffusion Tensor Imaging MH - Female MH - Humans MH - Limbic System/diagnostic imaging/*pathology MH - Male MH - Myelin Sheath/*pathology MH - Neural Pathways/diagnostic imaging/pathology MH - Psychotic Disorders/diagnostic imaging/*pathology/physiopathology MH - Risk MH - Schizophrenia/diagnostic imaging/*pathology/physiopathology MH - White Matter/diagnostic imaging/*pathology MH - Young Adult OTO - NOTNLM OT - Cingulum bundle OT - Diffusion Tensor Imaging OT - Fractional anisotropy OT - High risk psychosis OT - Limbic system OT - Myelination COIS- Declaration of competing interest All authors declare that they have no conflicts of interest. EDAT- 2019/09/04 06:00 MHDA- 2021/01/20 06:00 CRDT- 2019/09/04 06:00 PHST- 2018/11/26 00:00 [received] PHST- 2019/07/22 00:00 [revised] PHST- 2019/08/15 00:00 [accepted] PHST- 2019/09/04 06:00 [pubmed] PHST- 2021/01/20 06:00 [medline] PHST- 2019/09/04 06:00 [entrez] AID - S0920-9964(19)30358-5 [pii] AID - 10.1016/j.schres.2019.08.017 [doi] PST - ppublish SO - Schizophr Res. 2020 Jan;215:385-391. doi: 10.1016/j.schres.2019.08.017. Epub 2019 Aug 30.