PMID- 31478669
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20200630
LR  - 20200630
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 35
IP  - 48
DP  - 2019 Dec 3
TI  - Synergy between Zwitterionic Polymers and Hyaluronic Acid Enhances Antifouling 
      Performance.
PG  - 15535-15542
LID - 10.1021/acs.langmuir.9b01876 [doi]
AB  - Challenges associated with nonspecific adsorption of proteins on sensor surfaces 
      have steered the development of novel antifouling materials and strategies. 
      Inspired by human synovial fluid composition and structure, we designed 
      synergistic antifouling coatings with mixtures of hyaluronic acid (HA) and a 
      zwitterionic bottlebrush polymer (BB). Using a fast and convenient online surface 
      modification method, the polymers were immobilized on the Au surface, 
      significantly increasing its hydrophilicity. Using surface plasmon resonance 
      (SPR), a 10:1 ratio of HA to BB was found optimal to provide the best antifouling 
      performance. Bovine serum albumin (BSA) adsorption on HA-BB coated surfaces was 
      0.2 ng/cm(2), which was 60 times lower than BB or HA alone and 25 times lower 
      than the commonly accepted ultralow adsorption limit (<5 ng/cm(2)), demonstrating 
      the synergistic effect of HA and BB against nonspecific protein adsorption. This 
      was found to be independent of BSA concentration up to physiological 
      concentrations. Furthermore, the antifouling performance of HA-BB coated surfaces 
      was tested against milk and serum, showing almost 92% lower protein adsorption 
      than that on bare surfaces, suggesting the potential efficacy of this antifouling 
      coating in real life settings.
FAU - Xia, Yinqiang
AU  - Xia Y
AD  - State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane 
      Science and Desalination Technology, School of Chemical Engineering and 
      Technology , Tianjin University , Tianjin 300072 , P. R. China.
FAU - Adibnia, Vahid
AU  - Adibnia V
AUID- ORCID: 0000-0001-9006-8137
AD  - Faculty of Pharmacy , Universite de Montreal , 2900 Edouard-Montpetit , Montreal 
      , Quebec H3C 3J7 , Canada.
FAU - Shan, Cancan
AU  - Shan C
AD  - State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane 
      Science and Desalination Technology, School of Chemical Engineering and 
      Technology , Tianjin University , Tianjin 300072 , P. R. China.
FAU - Huang, Renliang
AU  - Huang R
AUID- ORCID: 0000-0003-0797-3473
AD  - Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of 
      Environmental Science and Engineering , Tianjin University , Tianjin 300072 , P. 
      R. China.
FAU - Qi, Wei
AU  - Qi W
AUID- ORCID: 0000-0002-7378-1392
AD  - State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane 
      Science and Desalination Technology, School of Chemical Engineering and 
      Technology , Tianjin University , Tianjin 300072 , P. R. China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , 
      Tianjin 300072 , China.
FAU - He, Zhimin
AU  - He Z
AD  - State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane 
      Science and Desalination Technology, School of Chemical Engineering and 
      Technology , Tianjin University , Tianjin 300072 , P. R. China.
FAU - Xie, Guojun
AU  - Xie G
AD  - Department of Chemistry , Carnegie Mellon University , 4400 Fifth Avenue , 
      Pittsburgh , Pennsylvania 15213 , United States.
FAU - Olszewski, Mateusz
AU  - Olszewski M
AD  - Department of Chemistry , Carnegie Mellon University , 4400 Fifth Avenue , 
      Pittsburgh , Pennsylvania 15213 , United States.
FAU - De Crescenzo, Gregory
AU  - De Crescenzo G
AUID- ORCID: 0000-0002-6280-1570
AD  - Ecole Polytechnique de Montreal , P.O. Box 6079, Station Centre-Ville , Montreal 
      , Quebec H3C 3A7 , Canada.
FAU - Matyjaszewski, Krzysztof
AU  - Matyjaszewski K
AUID- ORCID: 0000-0003-1960-3402
AD  - Department of Chemistry , Carnegie Mellon University , 4400 Fifth Avenue , 
      Pittsburgh , Pennsylvania 15213 , United States.
FAU - Banquy, Xavier
AU  - Banquy X
AUID- ORCID: 0000-0002-3342-3179
AD  - Faculty of Pharmacy , Universite de Montreal , 2900 Edouard-Montpetit , Montreal 
      , Quebec H3C 3J7 , Canada.
FAU - Su, Rongxin
AU  - Su R
AUID- ORCID: 0000-0001-9778-9113
AD  - State Key Laboratory of Chemical Engineering, Tianjin Key Laboratory of Membrane 
      Science and Desalination Technology, School of Chemical Engineering and 
      Technology , Tianjin University , Tianjin 300072 , P. R. China.
AD  - Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , 
      Tianjin 300072 , China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190911
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
SB  - IM
EDAT- 2019/09/04 06:00
MHDA- 2019/09/04 06:01
CRDT- 2019/09/04 06:00
PHST- 2019/09/04 06:00 [pubmed]
PHST- 2019/09/04 06:01 [medline]
PHST- 2019/09/04 06:00 [entrez]
AID - 10.1021/acs.langmuir.9b01876 [doi]
PST - ppublish
SO  - Langmuir. 2019 Dec 3;35(48):15535-15542. doi: 10.1021/acs.langmuir.9b01876. Epub 
      2019 Sep 11.