PMID- 31479636
OWN - NLM
STAT- MEDLINE
DCOM- 20200423
LR  - 20240210
IS  - 1552-6259 (Electronic)
IS  - 0003-4975 (Linking)
VI  - 109
IP  - 1
DP  - 2020 Jan
TI  - A Comparison of Frailty Measures at Listing to Predict Outcomes After Lung 
      Transplantation.
PG  - 233-240
LID - S0003-4975(19)31265-2 [pii]
LID - 10.1016/j.athoracsur.2019.07.040 [doi]
AB  - BACKGROUND: Sarcopenia may be an important predictive factor of outcomes after 
      lung transplantation (LTx). Serum albumin and the 6-minute walk distance (6MWD) 
      have been shown to be a marker of LTx outcomes. We measured sarcopenia, albumin, 
      and 6MWD in a cohort of LTx patients and analyzed the utility of these as markers 
      of outcomes for LTx patients. METHODS: We retrospectively identified LTx 
      recipients from 2013-2018 at our institution who underwent computed tomographic 
      imaging during their listing evaluation. From that image, we measured skeletal 
      muscle cross-sectional surface area at the third lumbar vertebral level, and 
      sarcopenia was diagnosed by established cutoffs. Associations between sarcopenia, 
      albumin, 6MWD, and survival, and hospital length of stay, complications, 
      readmissions, and discharge destination were evaluated. RESULTS: Sarcopenia was 
      found in 72% (95 of 132) of patients, 18% (24 of 131) of patients were 
      hypoalbuminemic, and 41% had a low 6MWD. Survival was not associated with 
      presence of sarcopenia (hazard ratio [HR], 1.06; 95% confidence interval [CI], 
      0.46-2.42) or low 6MWD (HR, 0.86; 95% CI, 0.410-1.83). Hospital length of stay, 
      complications, readmissions, and discharge destination were not influenced by 
      sarcopenia or 6MWD. In contrast, hypoalbuminemia was independently associated 
      with decreased survival (HR, 2.25; 95% CI, 1.04-4.85) and a higher grade of 
      postoperative complications (P = .04). CONCLUSIONS: Sarcopenia is prevalent in 
      LTx patients. Neither sarcopenia nor 6MWD predicted mortality or short-term 
      outcomes after LTx. This is in contrast to albumin levels, which were inversely 
      associated with survival and complications. Albumin shows promise as an important 
      predictor of mortality and short-term outcomes after LTx.
CI  - Copyright (c) 2020 The Society of Thoracic Surgeons. Published by Elsevier Inc. All 
      rights reserved.
FAU - Halpern, Alison L
AU  - Halpern AL
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado. Electronic 
      address: alison.halpern@ucdenver.edu.
FAU - Boshier, Piers R
AU  - Boshier PR
AD  - Cardiothoracic Surgery, Virginia Mason Hospital, Seattle, Washington.
FAU - White, Allana M
AU  - White AM
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado.
FAU - Houk, Anna K
AU  - Houk AK
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado.
FAU - Helmkamp, Laura
AU  - Helmkamp L
AD  - The Adult and Child Consortium for Health Outcomes Research and Delivery Science 
      (ACCORDS), University of Colorado, Aurora, Colorado.
FAU - Mitchell, John D
AU  - Mitchell JD
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado.
FAU - Meguid, Robert A
AU  - Meguid RA
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado; The Adult and 
      Child Consortium for Health Outcomes Research and Delivery Science (ACCORDS), 
      University of Colorado, Aurora, Colorado.
FAU - Low, Donald E
AU  - Low DE
AD  - Cardiothoracic Surgery, Virginia Mason Hospital, Seattle, Washington.
FAU - Fullerton, David A
AU  - Fullerton DA
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado.
FAU - Weyant, Michael J
AU  - Weyant MJ
AD  - Cardiothoracic Surgery, University of Colorado, Aurora, Colorado.
LA  - eng
GR  - 27981/CRUK_/Cancer Research UK/United Kingdom
PT  - Comparative Study
PT  - Journal Article
DEP - 20190831
PL  - Netherlands
TA  - Ann Thorac Surg
JT  - The Annals of thoracic surgery
JID - 15030100R
RN  - 0 (Serum Albumin)
SB  - IM
MH  - Female
MH  - Frailty/blood/complications/*diagnosis/physiopathology
MH  - Humans
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/epidemiology/etiology
MH  - Prognosis
MH  - Retrospective Studies
MH  - Sarcopenia/complications
MH  - Serum Albumin/analysis
MH  - Treatment Outcome
MH  - Walk Test
EDAT- 2019/09/04 06:00
MHDA- 2020/04/24 06:00
CRDT- 2019/09/04 06:00
PHST- 2019/01/29 00:00 [received]
PHST- 2019/06/07 00:00 [revised]
PHST- 2019/07/10 00:00 [accepted]
PHST- 2019/09/04 06:00 [pubmed]
PHST- 2020/04/24 06:00 [medline]
PHST- 2019/09/04 06:00 [entrez]
AID - S0003-4975(19)31265-2 [pii]
AID - 10.1016/j.athoracsur.2019.07.040 [doi]
PST - ppublish
SO  - Ann Thorac Surg. 2020 Jan;109(1):233-240. doi: 10.1016/j.athoracsur.2019.07.040. 
      Epub 2019 Aug 31.