PMID- 31480733
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 9
DP  - 2019 Sep 2
TI  - Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and 
      Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term 
      Titanium Dental Implants.
LID - 10.3390/jcm8091368 [doi]
LID - 1368
AB  - Titanium is the mean biocompatible metal found in dental titanium alloys 
      (Ti-6Al-4V). The safety of certain dental biomaterial amalgams has been 
      questioned in patients. The levels of several systemic cytokines (interleukin 
      (IL)-1 beta, IL-4: pg/mL) and chemokines (monocyte chemoattractant protein-1 
      (MCP-1), soluble fractalkine (CX3CL1: pg/mL) were determined using ELISA and 
      compared between these study groups. The study included 30 controls without 
      dental materials (cont), 57 patients with long-term titanium dental implants plus 
      amalgams (A + I group) as well as 55 patients with long-term dental amalgam alone 
      (A group). All patients (except controls) have had dental titanium implants 
      (Ti-6Al-4V) and/or amalgams for at least 10 years (average: 15 years). We 
      evaluated whether systemic levels of cytokines/chemokines, kyn/L-trp ratio and 
      aromatic amino acid levels (HPLC: mM/L, Phe, L-Trp, His, Treo) could be altered 
      in patients with long-term dental titanium and/or amalgams. These systemic 
      markers were evaluated in 142 patients. The A + I group had higher 
      L-Kynurenine/L-Tryptophan ratios than patients with long-term dental amalgam 
      fillings alone (A). In addition, levels of IL-1 Beta cytokine, CX3CL1 and MCP-1 
      chemokines were higher in the A + I group than in the A group (A). The increased 
      L-kyn/L-trp ratio and MCP-1 and fractalkine receptor (CX3CR1) elevations could 
      suggest enhanced chemotactic responses by these chemokines in the A + I group.
FAU - Merino, Jose Joaquin
AU  - Merino JJ
AD  - Departamento de Farmacologia, Farmacognosia y Botanica, Facultad de Farmacia, 
      Universidad Complutense de Madrid (U.C.M), c/Plaza Ramon y Cajal s/n, 28040 
      Madrid, Spain. info@jjmerino.com.
AD  - Centro CIROM, Centro de Implantologia y Rehabilitacion Oral Multidisciplinaria, 
      30001 Murcia, Spain. info@jjmerino.com.
FAU - Cabana-Munoz, Maria Eugenia
AU  - Cabana-Munoz ME
AD  - Centro CIROM, Centro de Implantologia y Rehabilitacion Oral Multidisciplinaria, 
      30001 Murcia, Spain.
FAU - Toledano Gasca, Adolfo
AU  - Toledano Gasca A
AD  - Department of Neuroanatomy, Instituto Cajal (CSIC), 28040 Madrid, Spain.
FAU - Garcimartin, Alba
AU  - Garcimartin A
AD  - Departamento de Farmacologia, Farmacognosia y Botanica, Facultad de Farmacia, 
      Universidad Complutense de Madrid (U.C.M), c/Plaza Ramon y Cajal s/n, 28040 
      Madrid, Spain.
FAU - Benedi, Juana
AU  - Benedi J
AD  - Departamento de Farmacologia, Farmacognosia y Botanica, Facultad de Farmacia, 
      Universidad Complutense de Madrid (U.C.M), c/Plaza Ramon y Cajal s/n, 28040 
      Madrid, Spain.
FAU - Camacho-Alonso, Fabio
AU  - Camacho-Alonso F
AD  - Faculty of Medicine, University of Murcia, 30100 Murcia, Spain.
FAU - Parmigiani-Izquierdo, Jose Maria
AU  - Parmigiani-Izquierdo JM
AD  - Centro CIROM, Centro de Implantologia y Rehabilitacion Oral Multidisciplinaria, 
      30001 Murcia, Spain.
LA  - eng
PT  - Journal Article
DEP - 20190902
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6780981
OTO - NOTNLM
OT  - CX3CL1 (fractalkine)
OT  - His
OT  - IDO
OT  - L-Kyn/L-Trp
OT  - amino acids
OT  - chemokines
OT  - chemotaxis
OT  - cytokines
OT  - dentistry and medical toxicology
OT  - inflammation
OT  - kynurenine pathways
OT  - melatonin
OT  - titanium dental implants and dental amalgam fillings
OT  - tryptophan (L-Trp), cytokines
COIS- The authors declare no conflict of interest.
EDAT- 2019/09/05 06:00
MHDA- 2019/09/05 06:01
PMCR- 2019/09/02
CRDT- 2019/09/05 06:00
PHST- 2019/08/13 00:00 [received]
PHST- 2019/08/27 00:00 [revised]
PHST- 2019/08/28 00:00 [accepted]
PHST- 2019/09/05 06:00 [entrez]
PHST- 2019/09/05 06:00 [pubmed]
PHST- 2019/09/05 06:01 [medline]
PHST- 2019/09/02 00:00 [pmc-release]
AID - jcm8091368 [pii]
AID - jcm-08-01368 [pii]
AID - 10.3390/jcm8091368 [doi]
PST - epublish
SO  - J Clin Med. 2019 Sep 2;8(9):1368. doi: 10.3390/jcm8091368.