PMID- 31482957
OWN - NLM
STAT- MEDLINE
DCOM- 20191031
LR  - 20231003
IS  - 2359-4292 (Electronic)
IS  - 2359-3997 (Print)
IS  - 2359-3997 (Linking)
VI  - 63
IP  - 5
DP  - 2019
TI  - Outcome and long-term follow-up of adrenal lesions in multiple endocrine 
      neoplasia type 1.
PG  - 516-523
LID - 10.20945/2359-3997000000170 [doi]
AB  - OBJECTIVE: To describe the prevalence, clinical characteristics and outcome of 
      adrenal lesions in long-term follow-up of Multiple endocrine neoplasia type 1 
      (MEN1) patients. SUBJECTS AND METHODS: We retrospectively studied sixteen 
      patients from six families of individuals with MEN1. Adrenal involvement was 
      evaluated using clinical, biochemical and imaging data. RESULTS: Adrenal lesions 
      were identified in nine of sixteen (56.3%) patients: seven women and two men 
      (mean age: 52.2 years). Adrenal involvement was detected at MEN1 diagnosis in 
      more than half of the patients. Eighteen adrenal nodules were founded (median of 
      two nodules per patient) with mean adrenal lesion diameter of 17.4 mm. Three 
      patients had unilateral adrenal involvement. Hormonal hypersecretion (autonomous 
      cortisol secretion) was found in two patients. None of the patients was submitted 
      to adrenalectomy, presented an aldosterone-secreting lesion, a pheochromocytoma, 
      an adrenal carcinoma or metastatic disease during the follow-up. A predominance 
      of stable adrenal disease, in terms of size and hormonal secretion, was observed. 
      Adrenal lesions were evenly distributed between the germline mutations. 
      CONCLUSION: Adrenal tumours are a common feature of MEN1 that can affect more 
      than half of the patients. Most of the tumours are bilateral non-functional 
      lesions, but hormonal secretion may occur and should be promptly identified to 
      reduce the morbidity/mortality of the syndrome. Periodic surveillance of these 
      patients should be performed.
FAU - Ventura, Mara
AU  - Ventura M
AUID- ORCID: 0000-0002-9749-6692
AD  - Faculty of Health Sciences, University of Beira Interior, Covilha, Portugal.
FAU - Melo, Miguel
AU  - Melo M
AUID- ORCID: 0000-0002-8365-1380
AD  - Endocrinology, Diabetes and Metabolism Department, University and Hospital Center 
      of Coimbra, Coimbra, Portugal.
AD  - Faculty of Medicine of the University of Coimbra, Coimbra, Portugal.
FAU - Carrilho, Francisco
AU  - Carrilho F
AUID- ORCID: 0000-0003-2564-3056
AD  - Endocrinology, Diabetes and Metabolism Department, University and Hospital Center 
      of Coimbra, Coimbra, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20190902
PL  - Brazil
TA  - Arch Endocrinol Metab
JT  - Archives of endocrinology and metabolism
JID - 101652058
SB  - IM
MH  - Adolescent
MH  - Adrenal Gland Neoplasms/*diagnostic imaging/genetics
MH  - Adult
MH  - Aged
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging/genetics
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC10522267
COIS- Disclosure: no potential conflict of interest relevant to this article was 
      reported.
EDAT- 2019/09/05 06:00
MHDA- 2019/11/02 06:00
PMCR- 2019/08/28
CRDT- 2019/09/05 06:00
PHST- 2018/06/15 00:00 [received]
PHST- 2019/05/28 00:00 [accepted]
PHST- 2019/09/05 06:00 [pubmed]
PHST- 2019/11/02 06:00 [medline]
PHST- 2019/09/05 06:00 [entrez]
PHST- 2019/08/28 00:00 [pmc-release]
AID - S2359-39972019005007106 [pii]
AID - 2359-3997000000170 [pii]
AID - 10.20945/2359-3997000000170 [doi]
PST - epublish
SO  - Arch Endocrinol Metab. 2019 Sep 2;63(5):516-523. doi: 
      10.20945/2359-3997000000170. eCollection 2019.