PMID- 31483941
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20220531
IS  - 1864-0648 (Electronic)
IS  - 1864-063X (Print)
IS  - 1864-063X (Linking)
VI  - 13
IP  - 3
DP  - 2020 Mar
TI  - Safety of light emitting diode-red light on human skin: Two randomized controlled 
      trials.
PG  - e201960014
LID - 10.1002/jbio.201960014 [doi]
AB  - Therapeutic applications of light emitting diode-red light (LED-RL) are 
      expanding, yet data on its clinical effects are lacking. Our goal was to evaluate 
      the safety of high fluence LED-RL (>/=160 J/cm(2) ). In two phase I, single-blind, 
      dose escalation, randomized controlled trials, healthy subjects received LED-RL 
      or mock irradiation to the forearm thrice weekly for 3 weeks at fluences of 
      160-640 J/cm(2) for all skin types (STARS 1, n = 60) and at 480-640 J/cm(2) for 
      non-Hispanic Caucasians (STARS 2, n = 55). The primary outcome was the incidence 
      of adverse events (AEs). The maximum tolerated dose was the highest fluence that 
      did not elicit predefined AEs. Dose-limiting AEs, including blistering and 
      prolonged erythema, occurred at 480 J/cm(2) in STARS 1 (n = 1) and 640 J/cm(2) in 
      STARS 2 (n = 2). AEs of transient erythema and hyperpigmentation were mild. No 
      serious AEs occurred. We determined that LED-RL is safe up to 320 J/cm(2) for 
      skin of color and 480 J/cm(2) for non-Hispanic Caucasian individuals. LED-RL may 
      exert differential cutaneous effects depending on race and ethnicity, with darker 
      skin being more photosensitive. These findings may guide future studies to 
      evaluate the efficacy of LED-RL for the treatment of various diseases.
CI  - (c) 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Jagdeo, Jared
AU  - Jagdeo J
AUID- ORCID: 0000-0002-7619-7650
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
FAU - Nguyen, Julie K
AU  - Nguyen JK
AD  - Department of Dermatology, The State University of New York Downstate Medical 
      Center, Brooklyn, New York.
AD  - Dermatology Service, VA New York Harbor Healthcare System Brooklyn Campus, 
      Brooklyn, New York.
FAU - Ho, Derek
AU  - Ho D
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
FAU - Wang, Erica B
AU  - Wang EB
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
FAU - Austin, Evan
AU  - Austin E
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
FAU - Mamalis, Andrew
AU  - Mamalis A
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Department of Dermatology, The State University of New York Downstate Medical 
      Center, Brooklyn, New York.
FAU - Kaur, Ramanjot
AU  - Kaur R
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
FAU - Kraeva, Ekaterina
AU  - Kraeva E
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
FAU - Schulman, Joshua M
AU  - Schulman JM
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
FAU - Li, Chin-Shang
AU  - Li CS
AD  - Department of Public Health Sciences, Division of Biostatistics, University of 
      California, Davis, Sacramento, California.
FAU - Hwang, Samuel T
AU  - Hwang ST
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
FAU - Wun, Ted
AU  - Wun T
AD  - Division of Hematology & Oncology, Department of Internal Medicine, University of 
      California, Davis, Sacramento, California.
AD  - Division of Hematology & Oncology, Sacramento VA Medical Center, Mather, 
      California.
AD  - UC Davis Clinical and Translational Sciences Center, Sacramento, California.
FAU - Maverakis, Emanual
AU  - Maverakis E
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
FAU - Isseroff, R Rivkah
AU  - Isseroff RR
AD  - Department of Dermatology, University of California, Davis, Sacramento, 
      California.
AD  - Dermatology Service, Sacramento VA Medical Center, Mather, California.
LA  - eng
GR  - K23 GM117309/GM/NIGMS NIH HHS/United States
GR  - K23GM117309/NH/NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20191208
PL  - Germany
TA  - J Biophotonics
JT  - Journal of biophotonics
JID - 101318567
SB  - IM
MH  - Humans
MH  - Light
MH  - *Low-Level Light Therapy
MH  - Single-Blind Method
MH  - *Skin/radiation effects
PMC - PMC8887049
MID - NIHMS1781281
OTO - NOTNLM
OT  - low-level light therapy
OT  - phototherapy
OT  - randomized controlled trial
OT  - skin pigmentation
EDAT- 2019/09/05 06:00
MHDA- 2021/06/24 06:00
PMCR- 2022/03/01
CRDT- 2019/09/05 06:00
PHST- 2019/06/26 00:00 [received]
PHST- 2019/08/31 00:00 [revised]
PHST- 2019/09/01 00:00 [accepted]
PHST- 2019/09/05 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2019/09/05 06:00 [entrez]
PHST- 2022/03/01 00:00 [pmc-release]
AID - 10.1002/jbio.201960014 [doi]
PST - ppublish
SO  - J Biophotonics. 2020 Mar;13(3):e201960014. doi: 10.1002/jbio.201960014. Epub 2019 
      Dec 8.