PMID- 31484245
OWN - NLM
STAT- MEDLINE
DCOM- 20190910
LR  - 20190910
IS  - 1001-0939 (Print)
IS  - 1001-0939 (Linking)
VI  - 42
IP  - 9
DP  - 2019 Sep 12
TI  - [The clinical experience of pirfenidone based on corticosteroids and 
      immunosuppressant treatment for interstitial pneumonia with autoimmune features].
PG  - 700-704
LID - 10.3760/cma.j.issn.1001-0939.2019.09.009 [doi]
AB  - Objective: To explore the effect of pirfenidone in fibrotic interstitial 
      pneumonia with autoimmune features (IPAF) after treatment with corticosteroids 
      and immunosuppressants. Methods: We conducted a retrospective analysis of 2 adult 
      patients with IPAF in the Peking Union Medical College Hospital. As their 
      fibrotic interstitial lung disease failed to improve with further treatment with 
      corticosteroids and immunosuppressants, they were treated with pirfenidone based 
      on corticosteroids and immunosuppressants. Their clinical, chest radiological 
      data and prognosis were collected and relevant literatures were reviewed. 
      Results: One patient was a 43 year old female, the other was a 53 year old male. 
      IPAF was diagnosed with their classic clinical, serological and radiological 
      features. They were partially responded to corticosteroids and immunosuppressants 
      at the initial period. Pirfenidone was suggested for them as their lung fibrosis 
      was not improved further with immunosuppressive therapy. After 4-5 months 
      treatment with pirfenidone, based on corticosteroids and immunosuppressant 
      administration, their clinical and radiological manifestations improved 
      significantly. Conclusions: Pirfenidone might be a good add-on choice for 
      fibrotic IPAF when the disease did not respond well to corticosteroids and 
      immunosuppressants.
FAU - Huang, H
AU  - Huang H
AD  - Department of Respiratory Medicine, Peking Union Medical College Hospital, 
      Beijing 100730, China.
FAU - Sun, Y X
AU  - Sun YX
AD  - Department of Respiratory Medicine, Peking Union Medical College Hospital, 
      Beijing 100730, China.
FAU - Li, S
AU  - Li S
AD  - Department of Respiratory Medicine, Peking Union Medical College Hospital, 
      Beijing 100730, China.
FAU - Shao, C
AU  - Shao C
AD  - Department of Respiratory Medicine, Peking Union Medical College Hospital, 
      Beijing 100730, China.
FAU - Xu, K
AU  - Xu K
AD  - Department of Radiology, Peking Union Medical College Hospital, Beijing 100730, 
      China.
FAU - Xu, Z J
AU  - Xu ZJ
AD  - Department of Respiratory Medicine, Peking Union Medical College Hospital, 
      Beijing 100730, China.
LA  - chi
GR  - 81600050/National Nature Science Foundation of China/
GR  - 2016YFC0905700/Chinese National Science and Technology Ministry/
GR  - 3332016003/Fundamental Research Funds for the Central Universities and the PUMC 
      Youth Fund/
PT  - Journal Article
PL  - China
TA  - Zhonghua Jie He He Hu Xi Za Zhi
JT  - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal 
      of tuberculosis and respiratory diseases
JID - 8712226
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Pyridones)
RN  - D7NLD2JX7U (pirfenidone)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Adult
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Autoimmune Diseases/*diagnosis
MH  - Female
MH  - Humans
MH  - Idiopathic Pulmonary Fibrosis/diagnosis/*drug therapy
MH  - Immunosuppressive Agents/therapeutic use
MH  - Lung Diseases, Interstitial/*diagnosis/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Pyridones/*therapeutic use
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Fibrotic pattern
OT  - Interstitial pneumonia with autoimmune feature
OT  - Pirfenidone
EDAT- 2019/09/05 06:00
MHDA- 2019/09/11 06:00
CRDT- 2019/09/05 06:00
PHST- 2019/09/05 06:00 [entrez]
PHST- 2019/09/05 06:00 [pubmed]
PHST- 2019/09/11 06:00 [medline]
AID - 10.3760/cma.j.issn.1001-0939.2019.09.009 [doi]
PST - ppublish
SO  - Zhonghua Jie He He Hu Xi Za Zhi. 2019 Sep 12;42(9):700-704. doi: 
      10.3760/cma.j.issn.1001-0939.2019.09.009.