PMID- 31485302
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20231013
IS  - 1942-0994 (Electronic)
IS  - 1942-0900 (Print)
IS  - 1942-0994 (Linking)
VI  - 2019
DP  - 2019
TI  - The Research Progress of Host Genes and Tuberculosis Susceptibility.
PG  - 9273056
LID - 10.1155/2019/9273056 [doi]
LID - 9273056
AB  - BACKGROUND/AIMS: Nucleotide diversity may affect the immune regulation of 
      tuberculosis (TB) patients, leading to the individual susceptibility to TB. In 
      recent years, there are a lot of researches on the association of host genetic 
      factors and TB susceptibility which has attracted increasing attention, and the 
      in-depth study of its mechanism is gradually clear. MATERIALS: We made a 
      minireview on the association of many candidate genes with TB based on recent 
      research studies systematically, such as the human leukocyte antigen (HLA) gene, 
      the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D 
      receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide 
      synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor 
      (P2X7) gene. The discovery of these candidate genes could reveal the pathogenesis 
      of TB comprehensively and is crucial to provide scientific evidence for 
      formulating the related measures of prevention and cure. DISCUSSION: The host 
      genes play important roles in the development of TB, and the host genes may 
      become new targets for the prevention and treatment of TB. Effective regulation 
      of host genes may help prevent or even treat TB. CONCLUSION: This minireview 
      focuses on the association of host genes with the development of TB, which may 
      supply some clues for future therapies and novel drug targets for TB.
FAU - Cai, Li
AU  - Cai L
AD  - Wuhan Center for Disease Control and Prevention, Wuhan 430015, China.
AD  - School of Health Sciences, Wuhan University, Wuhan 430071, China.
FAU - Li, Zhan
AU  - Li Z
AD  - School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Guan, Xuhua
AU  - Guan X
AD  - Hubei Center for Disease Control and Prevention, 430079, China.
FAU - Cai, Kun
AU  - Cai K
AD  - Hubei Center for Disease Control and Prevention, 430079, China.
FAU - Wang, Lei
AU  - Wang L
AD  - Hubei Center for Disease Control and Prevention, 430079, China.
FAU - Liu, Jiafa
AU  - Liu J
AUID- ORCID: 0000-0002-6584-9035
AD  - School of Health Sciences, Wuhan University, Wuhan 430071, China.
AD  - Hubei Center for Disease Control and Prevention, 430079, China.
FAU - Tong, Yeqing
AU  - Tong Y
AUID- ORCID: 0000-0002-8971-3968
AD  - Hubei Center for Disease Control and Prevention, 430079, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190814
PL  - United States
TA  - Oxid Med Cell Longev
JT  - Oxidative medicine and cellular longevity
JID - 101479826
SB  - IM
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Tuberculosis/*genetics
PMC - PMC6710736
COIS- The authors declare no conflicts of interest.
EDAT- 2019/09/06 06:00
MHDA- 2020/01/28 06:00
PMCR- 2019/08/14
CRDT- 2019/09/06 06:00
PHST- 2019/01/25 00:00 [received]
PHST- 2019/05/05 00:00 [revised]
PHST- 2019/05/29 00:00 [accepted]
PHST- 2019/09/06 06:00 [entrez]
PHST- 2019/09/06 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2019/08/14 00:00 [pmc-release]
AID - 10.1155/2019/9273056 [doi]
PST - epublish
SO  - Oxid Med Cell Longev. 2019 Aug 14;2019:9273056. doi: 10.1155/2019/9273056. 
      eCollection 2019.