PMID- 31486118
OWN - NLM
STAT- MEDLINE
DCOM- 20200114
LR  - 20200114
IS  - 1365-3083 (Electronic)
IS  - 0300-9475 (Linking)
VI  - 91
IP  - 1
DP  - 2020 Jan
TI  - Food allergy-From food avoidance to active treatment.
PG  - e12824
LID - 10.1111/sji.12824 [doi]
AB  - The prevalence of food allergy (FA) has increased too rapidly, possibly due to 
      environmental factors. The guidelines recommend strict allergen avoidance, but FA 
      is still the main cause of anaphylaxis in all age groups. Immunotherapy is the 
      only treatment able to change the course of allergic disease, and oral 
      immunotherapy (OIT) is the more effective route in FA. However, it carries the 
      risk of adverse reactions, including anaphylaxis. To improve OIT safety, adjuvant 
      therapy with the immunoglobulin E (IgE) monoclonal antibody omalizumab has been 
      extensively used. Results suggest particular benefit in patients with high risk 
      of fatal anaphylaxis. An alternative approach is to use omalizumab instead of OIT 
      to prevent severe allergic reactions upon accidental exposure. This paper reviews 
      current evidence regarding IgE-mediated FA, focusing on natural tolerance and 
      food sensitization acquisition, and on avoidance measures and their limitations.
CI  - (c) 2019 The Scandinavian Foundation for Immunology.
FAU - Costa, Celia
AU  - Costa C
AUID- ORCID: 0000-0001-8313-1505
AD  - Immunoallergology Department, Hospital de Santa Maria, Centro Hospitalar 
      Universitario de Lisboa Norte (CHLN), EPE, Lisbon, Portugal.
FAU - Coimbra, Alice
AU  - Coimbra A
AD  - Immunoallergology Department, Hospital de S. Joao EPE, Centro Hospitalar de Sao 
      Joao (CHSJ), Porto, Portugal.
FAU - Vitor, Artur
AU  - Vitor A
AD  - Pediatrics Department, Hospital de S. Joao EPE, Centro Hospitalar de Sao Joao 
      (CHSJ), Porto, Portugal.
FAU - Aguiar, Rita
AU  - Aguiar R
AD  - Immunoallergology Department, Hospital de Santa Maria, Centro Hospitalar 
      Universitario de Lisboa Norte (CHLN), EPE, Lisbon, Portugal.
FAU - Ferreira, Ana Luisa
AU  - Ferreira AL
AD  - Immunoallergology Department, Centro Hospitalar de Vila Nova de Gaia/Espinho 
      (CHVNGE), Vila Nova de Gaia, Portugal.
FAU - Todo-Bom, Ana
AU  - Todo-Bom A
AD  - Immunoallergology Department, Centro Hospitalar e Universitario de Coimbra 
      (CHUC), Coimbra, Portugal.
AD  - Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
LA  - eng
GR  - Novartis Portugal/
PT  - Journal Article
PT  - Review
DEP - 20191124
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Animals
MH  - *Desensitization, Immunologic/adverse effects/methods
MH  - Food/*adverse effects
MH  - Food Hypersensitivity/epidemiology/*immunology/prevention & control/*therapy
MH  - Humans
MH  - Immune Tolerance
MH  - Immunization
MH  - Immunoglobulin E/immunology
OTO - NOTNLM
OT  - IgE-mediated food allergies
OT  - avoidance measures
OT  - food sensitization
EDAT- 2019/09/06 06:00
MHDA- 2020/01/15 06:00
CRDT- 2019/09/06 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/07/14 00:00 [revised]
PHST- 2019/08/29 00:00 [accepted]
PHST- 2019/09/06 06:00 [pubmed]
PHST- 2020/01/15 06:00 [medline]
PHST- 2019/09/06 06:00 [entrez]
AID - 10.1111/sji.12824 [doi]
PST - ppublish
SO  - Scand J Immunol. 2020 Jan;91(1):e12824. doi: 10.1111/sji.12824. Epub 2019 Nov 24.