PMID- 31486344
OWN - NLM
STAT- MEDLINE
DCOM- 20200420
LR  - 20200420
IS  - 1744-7593 (Electronic)
IS  - 1742-5247 (Linking)
VI  - 16
IP  - 11
DP  - 2019 Nov
TI  - Biomedical potential of clay nanotube formulations and their toxicity assessment.
PG  - 1169-1182
LID - 10.1080/17425247.2019.1665020 [doi]
AB  - Introduction: Halloysite clay nanotubes (HNTs) are a naturally abundant and 
      biocompatible aluminosilicate material with a structure able to encapsulate 
      10-20% of drugs. These features are attractive toward the clinical application in 
      controlled drug delivery, tissue engineering and regenerative medicine. Areas 
      covered: We describe the application of HNTs as a viable method for clinical 
      purposes, particularly developing formulations for prophylaxis, diagnosis and 
      therapeutics, having a special attention to these nanotubes bio-safety. HNTs may 
      be used for pharmaceuticals, biopharmaceuticals, wound healing, bone 
      regeneration, dental repair, hair surface engineering and biomimetic 
      applications. Expert opinion: HNTs are a versatile, safe and biocompatible 
      nanomaterial used for drug encapsulation for numerous clinical applications. The 
      studies here reviewed confirm the HNTs biocompatibility, describing their low 
      toxicity. Further developments will be made regarding the long-term efficacy of 
      halloysite-based treatments in humans, concentrating mostly on topical 
      applications.
FAU - Santos, Ana Claudia
AU  - Santos AC
AUID- ORCID: 0000-0003-2710-6000
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, University of 
      Coimbra , Coimbra , Portugal.
AD  - REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, 
      University of Coimbra , Coimbra , Portugal.
FAU - Pereira, Irina
AU  - Pereira I
AUID- ORCID: 0000-0002-9879-5213
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, University of 
      Coimbra , Coimbra , Portugal.
AD  - REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, 
      University of Coimbra , Coimbra , Portugal.
FAU - Reis, Salette
AU  - Reis S
AUID- ORCID: 0000-0002-0736-2835
AD  - REQUIMTE/LAQV, Department of Chemical Sciences, Faculty of Pharmacy, University 
      of Porto , Porto , Portugal.
FAU - Veiga, Francisco
AU  - Veiga F
AUID- ORCID: 0000-0002-1041-0068
AD  - Department of Pharmaceutical Technology, Faculty of Pharmacy, University of 
      Coimbra , Coimbra , Portugal.
AD  - REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy, 
      University of Coimbra , Coimbra , Portugal.
FAU - Saleh, Mahdi
AU  - Saleh M
AUID- ORCID: 0000-0001-5429-0224
AD  - Institute for Micromanufacturing, Louisiana Tech University , Ruston , LA , USA.
FAU - Lvov, Yuri
AU  - Lvov Y
AUID- ORCID: 0000-0003-0722-5643
AD  - Institute for Micromanufacturing, Louisiana Tech University , Ruston , LA , USA.
AD  - Department of Theoretical Physics and Quantum Technologies, National University 
      of Science and Technology "MISiS" , Moscow , Russia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190912
PL  - England
TA  - Expert Opin Drug Deliv
JT  - Expert opinion on drug delivery
JID - 101228421
RN  - T1FAD4SS2M (Clay)
SB  - IM
MH  - Animals
MH  - *Clay/chemistry
MH  - Drug Compounding
MH  - *Drug Delivery Systems
MH  - Drug Liberation
MH  - Humans
MH  - *Nanotubes/chemistry/toxicity
OTO - NOTNLM
OT  - Halloysite clay nanotubes
OT  - bioimaging
OT  - biosensor
OT  - drug therapy
OT  - regenerative medicine
OT  - tissue engineering
OT  - toxicity
EDAT- 2019/09/06 06:00
MHDA- 2020/04/21 06:00
CRDT- 2019/09/06 06:00
PHST- 2019/09/06 06:00 [pubmed]
PHST- 2020/04/21 06:00 [medline]
PHST- 2019/09/06 06:00 [entrez]
AID - 10.1080/17425247.2019.1665020 [doi]
PST - ppublish
SO  - Expert Opin Drug Deliv. 2019 Nov;16(11):1169-1182. doi: 
      10.1080/17425247.2019.1665020. Epub 2019 Sep 12.