PMID- 31487028
OWN - NLM
STAT- MEDLINE
DCOM- 20190917
LR  - 20190917
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1169
DP  - 2019
TI  - Sources, Identification, and Clinical Implications of Heterogeneity in Human 
      Umbilical Cord Stem Cells.
PG  - 243-256
LID - 10.1007/978-3-030-24108-7_13 [doi]
AB  - Heterogeneity among different subpopulations of human umbilical cord mesenchymal 
      stem cell (hUCMSCs) lines is an ubiquitous phenomenon, with such variability 
      being related to several factors including the identity of the individual donor, 
      tissue source (Wharton's jelly vs. umbilical cord blood), culture conditions, as 
      well as random variations in the cloning expansion process. In this chapter, we 
      provide a general overview on the sources as well as available experimental 
      techniques for proper identification of heterogeneity in hUCMSCs. Finally, we 
      provide a brief discussion on the current scientific evidence regarding the 
      potential superiority of subpopulations of hUCMSCs for specific clinical 
      applications. Taking into account the exponential growth on the available 
      experimental data on hUCMSCs in the past few years, this chapter is not intended 
      to be comprehensive in nature, but rather is intended to provide a general 
      overview about the central role which the topic of heterogeneity has in both 
      basic science and clinical research in umbilical cord stem cells.
FAU - Lyons, Frank G
AU  - Lyons FG
AD  - Department of Orthopaedic Surgery, Sunnybrook Health Sciences Centre, University 
      of Toronto, Toronto, ON, Canada.
FAU - Mattei, Tobias A
AU  - Mattei TA
AD  - Department of Neurological Surgery, Saint Louis University, St. Louis, MO, USA. 
      tobias.mattei@health.slu.edu.
AD  - SSM Saint Louis University Hospital, St. Louis, MO, USA. 
      tobias.mattei@health.slu.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Fetal Blood/cytology
MH  - Humans
MH  - *Mesenchymal Stem Cells/cytology
MH  - *Umbilical Cord/cytology
MH  - Wharton Jelly
OTO - NOTNLM
OT  - Cloning expansion
OT  - Heterogeneity
OT  - Immunomodulation
OT  - Mesenchymal stem cells
OT  - Stem cell differentiation
OT  - Stem cell harvest
OT  - Stem cell heterogeneity
OT  - Stem cell therapy
OT  - Umbilical cord bank
OT  - Umbilical cord stem cells
EDAT- 2019/09/06 06:00
MHDA- 2019/09/19 06:00
CRDT- 2019/09/06 06:00
PHST- 2019/09/06 06:00 [entrez]
PHST- 2019/09/06 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
AID - 10.1007/978-3-030-24108-7_13 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2019;1169:243-256. doi: 10.1007/978-3-030-24108-7_13.