PMID- 31488035
OWN - NLM
STAT- MEDLINE
DCOM- 20200207
LR  - 20200207
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 47
IP  - 6
DP  - 2019
TI  - A Benzenoid 4,7-Dimethoxy-5-Methyl-L, 3-Benzodioxole from Antrodia cinnamomea 
      Attenuates Dendritic Cell-Mediated Th2 Allergic Responses.
PG  - 1271-1287
LID - 10.1142/S0192415X19500654 [doi]
AB  - Dendritic cells (DCs) play a critical role in initiating immune responses; 
      however, DCs also induce Th2-related allergic sensitivities. Thus, DCs become a 
      target for therapeutic design in allergic diseases. In this study, we aim to 
      investigate the anti-allergic effect of pure compounds from a medicinal mushroom 
      Antrodia cinnamomea (Ac) on DC-induced allergic responses. We identified a 
      benzenoid compound 4,7-dimethoxy-5-methyl-l,3-benzodioxole (DMB) which may 
      modulate Th2 polarization in bone marrow-derived DCs (BMDCs) and in a murine food 
      allergy model. DMB effectively reduced the Th2 adjuvant cholera toxin 
      (CT)-induced BMDC maturation and cytokine production. In studying the mechanism, 
      DMB blocked the molecular processes involved in Th2 induction, including cAMP 
      activation, IL-33 production, and IRF4/Tim4 upregulation, in CT-activated BMDCs. 
      Furthermore, DMB treatment attenuated the symptoms, clinical scores, and Th2 
      responses of CT-induced ovalbumin (OVA)-specific food allergy in mice at 
      sensitization stage. These results indicated that DMB could suppress DC function 
      for Th2 polarization and mitigate allergic responses. Thus, DMB may have 
      potential to be a novel agent for preventing or treating food allergy.
FAU - You, Ren-In
AU  - You RI
AD  - Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, 
      Taiwan.
FAU - Lee, Yi-Pang
AU  - Lee YP
AD  - Department of Health Administration, Tzu Chi University of Science and 
      Technology, Hualien, Taiwan.
AD  - Division of Oral Pathology, Department of Dentistry, Tzu Chi General Hospital, 
      Hualien, Taiwan.
FAU - Su, Ting-Yi
AU  - Su TY
AD  - Graduate Institute of Immunology, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
FAU - Lin, Chi-Chien
AU  - Lin CC
AD  - Institute of Biomedical Sciences, National Chung Hsin University, Taichung, 
      Taiwan.
FAU - Chen, Chang-Shan
AU  - Chen CS
AD  - Department of Laboratory Medicine and Biotechnology, Tzu Chi University, Hualien, 
      Taiwan.
FAU - Chu, Ching-Liang
AU  - Chu CL
AD  - Graduate Institute of Immunology, College of Medicine, National Taiwan 
      University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20190905
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Benzodioxoles)
RN  - 0 (Cytokines)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - *Anti-Allergic Agents
MH  - Antrodia/*chemistry
MH  - Benzodioxoles/*pharmacology/*therapeutic use
MH  - Cells, Cultured
MH  - Cytokines/metabolism
MH  - Dendritic Cells/*immunology
MH  - Disease Models, Animal
MH  - Food Hypersensitivity/*drug therapy/immunology/prevention & control
MH  - Hypersensitivity/*drug therapy
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - *Phytotherapy
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - Antrodia cinnamomea
OT  - Cholera Toxin
OT  - Dendritic Cell
OT  - Food Allergy
OT  - Th2
EDAT- 2019/09/07 06:00
MHDA- 2020/02/08 06:00
CRDT- 2019/09/07 06:00
PHST- 2019/09/07 06:00 [pubmed]
PHST- 2020/02/08 06:00 [medline]
PHST- 2019/09/07 06:00 [entrez]
AID - 10.1142/S0192415X19500654 [doi]
PST - ppublish
SO  - Am J Chin Med. 2019;47(6):1271-1287. doi: 10.1142/S0192415X19500654. Epub 2019 
      Sep 5.