PMID- 31490659
OWN - NLM
STAT- MEDLINE
DCOM- 20200212
LR  - 20200212
IS  - 1944-8252 (Electronic)
IS  - 1944-8244 (Linking)
VI  - 11
IP  - 39
DP  - 2019 Oct 2
TI  - Smart Unimolecular Micelle-Based Polyprodrug with Dual-Redox Stimuli Response for 
      Tumor Microenvironment: Enhanced in Vivo Delivery Efficiency and Tumor 
      Penetration.
PG  - 36130-36140
LID - 10.1021/acsami.9b13214 [doi]
AB  - Low delivery efficiency and limited tumor penetration of nanoparticle-based drug 
      delivery systems (DDSs), the two most concerned issues in tumor therapy, have 
      been considered as the "Achilles' heel" for tumor treatment. In this study, we 
      have designed a highly sensitive dual-redox-responsive prodrug-based starlike 
      polymer beta-CD-b-P(CPT(GSH)-co-CPT(ROS)-co-OEGMA) (CP(GR)) for synergistic 
      chemotherapy. The high glutathione (GSH) concentration and high reactive oxygen 
      species (ROS) levels are in a dynamic equilibrium in the tumor microenvironment 
      (TME) and could trigger the disintegration of CP(GR) micelles, which can promote 
      the release of anticancer drug camptothecin (CPT) completely and intelligently. 
      In order to verify the synergistic antitumor mechanism, two corresponding 
      single-responsive beta-CD-b-P(CPT(GSH)-co-OEGMA) (CP(G)) and 
      beta-CD-b-P(CPT(ROS)-co-OEGMA) (CP(R)) were altogether prepared as contrast. Both in 
      vitro and in vivo studies confirmed the enhanced anticancer activity of CP(GR) 
      micelles in comparison of single responsive micelles. This work contributes to 
      the orchestrated design of dual-redox-responsive DDSs for synergetic antitumor 
      chemotherapy, which provides a good approach for the development of 
      dual-redox-responsive nanomedicine.
FAU - Bai, Shuang
AU  - Bai S
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Ma, Xiaoqian
AU  - Ma X
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Shi, Xiaoxiao
AU  - Shi X
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Shao, Jinjun
AU  - Shao J
AUID- ORCID: 0000-0001-6446-8073
AD  - Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced 
      Materials (IAM) , Nanjing Tech University (NanjingTech) , Nanjing 211816 , P.R. 
      China.
FAU - Zhang, Tian
AU  - Zhang T
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Wang, Yajun
AU  - Wang Y
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Cheng, Yilong
AU  - Cheng Y
AD  - Department of Applied Chemistry, School of Science , Xi'an Jiaotong University , 
      Xi'an 710049 , China.
FAU - Xue, Peng
AU  - Xue P
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Kang, Yuejun
AU  - Kang Y
AUID- ORCID: 0000-0002-1021-0349
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
FAU - Xu, Zhigang
AU  - Xu Z
AUID- ORCID: 0000-0003-1805-5061
AD  - Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest 
      University), Ministry of Education, School of Materials and Energy , Southwest 
      University , Chongqing 400715 , P. R. China.
AD  - Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and 
      Devices , Chongqing 400715 , P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20190918
PL  - United States
TA  - ACS Appl Mater Interfaces
JT  - ACS applied materials & interfaces
JID - 101504991
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Micelles)
RN  - 0 (Prodrugs)
RN  - XT3Z54Z28A (Camptothecin)
SB  - IM
MH  - Animals
MH  - *Camptothecin/chemistry/pharmacokinetics/pharmacology
MH  - Delayed-Action Preparations/chemistry/pharmacokinetics/pharmacology
MH  - Female
MH  - HeLa Cells
MH  - Humans
MH  - MCF-7 Cells
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - *Micelles
MH  - *Neoplasms, Experimental/drug therapy/metabolism/pathology
MH  - Oxidation-Reduction
MH  - *Prodrugs/chemistry/pharmacokinetics/pharmacology
MH  - Tumor Microenvironment/*drug effects
MH  - Xenograft Model Antitumor Assays
OTO - NOTNLM
OT  - cancer therapy
OT  - delivery efficiency
OT  - dual-redox response
OT  - tumor microenvironment (TME)
OT  - tumor penetration
EDAT- 2019/09/07 06:00
MHDA- 2020/02/13 06:00
CRDT- 2019/09/07 06:00
PHST- 2019/09/07 06:00 [pubmed]
PHST- 2020/02/13 06:00 [medline]
PHST- 2019/09/07 06:00 [entrez]
AID - 10.1021/acsami.9b13214 [doi]
PST - ppublish
SO  - ACS Appl Mater Interfaces. 2019 Oct 2;11(39):36130-36140. doi: 
      10.1021/acsami.9b13214. Epub 2019 Sep 18.