PMID- 31491594
OWN - NLM
STAT- MEDLINE
DCOM- 20200806
LR  - 20200806
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 84
DP  - 2019 Dec
TI  - Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and 
      cognition.
PG  - 41-49
LID - S0197-4580(19)30219-2 [pii]
LID - 10.1016/j.neurobiolaging.2019.07.015 [doi]
AB  - Measuring the morphology of brain sulci has been recently proposed as a novel 
      imaging approach in Alzheimer's disease (AD). We aimed to investigate the 
      relevance of such an approach in AD, by exploring its (1) clinical relevance in 
      comparison with traditional imaging methods, (2) relationship with amyloid 
      deposition, (3) association with cognitive functions. Here, 51 patients (n = 32 
      mild cognitive impairment/mild dementia-AD, n = 19 moderate/severe dementia-AD) 
      diagnosed according to clinical-biological criteria (CSF biomarkers and 
      amyloid-PET) and 29 controls (with negative amyloid-PET) underwent 
      neuropsychological and 3T-MRI examinations. Mean sulcal width (SW) and mean 
      cortical thickness around the sulcus (CT-S) were automatically measured. We found 
      higher SW and lower CT-S in patients with AD than in controls. These differences 
      were more pronounced at later stages of the disease and provided the best 
      diagnostic accuracies among the imaging markers. Correlations were not found 
      between CT-S or SW and amyloid deposition but between specific cognitive 
      functions and regional CT-S/SW in key associated regions. Sulcal morphology is a 
      good supporting diagnosis tool that reflects the main cognitive impairments in 
      AD. It could be considered as a good surrogate marker to evaluate the efficacy of 
      new drugs.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Bertoux, Maxime
AU  - Bertoux M
AD  - Univ Lille, Inserm, CHU Lille, UMR 1171, Degenerative and Vascular Cognitive 
      Disorders, Lille, France; Unit of Neurology of Memory and Language, Universite 
      Paris Descartes, Sorbonne Paris Cite, Centre Hospitalier Sainte Anne, Paris, 
      France. Electronic address: maxime.bertoux@inserm.fr.
FAU - Lagarde, Julien
AU  - Lagarde J
AD  - Unit of Neurology of Memory and Language, Universite Paris Descartes, Sorbonne 
      Paris Cite, Centre Hospitalier Sainte Anne, Paris, France; UMR 1023 IMIV, Service 
      Hospitalier Frederic Joliot, CEA, Inserm, Universite Paris Sud, CNRS, Universite 
      Paris-Saclay, Orsay, France.
FAU - Corlier, Fabian
AU  - Corlier F
AD  - Imaging Genetics Center, USC Stevens Neuroimaging and Informatics Institute, Keck 
      School of Medicine of USC, University of Southern California, USA.
FAU - Hamelin, Lorraine
AU  - Hamelin L
AD  - Unit of Neurology of Memory and Language, Universite Paris Descartes, Sorbonne 
      Paris Cite, Centre Hospitalier Sainte Anne, Paris, France; UMR 1023 IMIV, Service 
      Hospitalier Frederic Joliot, CEA, Inserm, Universite Paris Sud, CNRS, Universite 
      Paris-Saclay, Orsay, France.
FAU - Mangin, Jean-Francois
AU  - Mangin JF
AD  - Neurospin, CEA, Gif-sur-Yvette, France.
FAU - Colliot, Olivier
AU  - Colliot O
AD  - Institut du Cerveau et de la Moelle epiniere, ICM, Inserm, Sorbonne Universites, 
      UPMC Univ Paris 06, Paris, France.
FAU - Chupin, Marie
AU  - Chupin M
AD  - Institut du Cerveau et de la Moelle epiniere, ICM, Inserm, Sorbonne Universites, 
      UPMC Univ Paris 06, Paris, France.
FAU - Braskie, Meredith N
AU  - Braskie MN
AD  - Imaging Genetics Center, USC Stevens Neuroimaging and Informatics Institute, Keck 
      School of Medicine of USC, University of Southern California, USA.
FAU - Thompson, Paul M
AU  - Thompson PM
AD  - Imaging Genetics Center, USC Stevens Neuroimaging and Informatics Institute, Keck 
      School of Medicine of USC, University of Southern California, USA.
FAU - Bottlaender, Michel
AU  - Bottlaender M
AD  - UMR 1023 IMIV, Service Hospitalier Frederic Joliot, CEA, Inserm, Universite Paris 
      Sud, CNRS, Universite Paris-Saclay, Orsay, France; Neurospin, CEA, 
      Gif-sur-Yvette, France.
FAU - Sarazin, Marie
AU  - Sarazin M
AD  - Unit of Neurology of Memory and Language, Universite Paris Descartes, Sorbonne 
      Paris Cite, Centre Hospitalier Sainte Anne, Paris, France; UMR 1023 IMIV, Service 
      Hospitalier Frederic Joliot, CEA, Inserm, Universite Paris Sud, CNRS, Universite 
      Paris-Saclay, Orsay, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190729
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Alzheimer Disease/*diagnosis/pathology/*physiopathology
MH  - Brain/*pathology
MH  - *Cognition
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Cortical thickness
OT  - Data-driven science
OT  - Sulcal morphology
OT  - Sulcal width
EDAT- 2019/09/07 06:00
MHDA- 2020/08/07 06:00
CRDT- 2019/09/07 06:00
PHST- 2018/10/25 00:00 [received]
PHST- 2019/07/23 00:00 [revised]
PHST- 2019/07/24 00:00 [accepted]
PHST- 2019/09/07 06:00 [pubmed]
PHST- 2020/08/07 06:00 [medline]
PHST- 2019/09/07 06:00 [entrez]
AID - S0197-4580(19)30219-2 [pii]
AID - 10.1016/j.neurobiolaging.2019.07.015 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2019 Dec;84:41-49. doi: 10.1016/j.neurobiolaging.2019.07.015. 
      Epub 2019 Jul 29.