PMID- 31491608
OWN - NLM
STAT- MEDLINE
DCOM- 20200225
LR  - 20200225
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 132
DP  - 2019 Nov
TI  - Association between serum heavy metals and prostate cancer risk - A multiple 
      metal analysis.
PG  - 105109
LID - S0160-4120(19)31095-5 [pii]
LID - 10.1016/j.envint.2019.105109 [doi]
AB  - BACKGROUND: Prostate cancer is one of the most prevalent cancers in men. Exposure 
      to heavy metals and their association with prostate cancer risk has been studied 
      extensively, but combined effects remain largely inconclusive. OBJECTIVES: To 
      elucidate the association between serum concentrations of heavy metals and 
      prostate cancer risk. METHODS: Inductively coupled plasma mass spectrometry 
      (ICP-MS) was used to determine the concentrations of a panel of 10 heavy metals 
      (Mn, Cu, Zn, As, Se, Sb, Co, Cu, Cd and Pb) in serum samples of 141 cases and 114 
      controls in the Singapore Prostate Cancer Study. Linear probit regression models 
      were used to estimate risk differences (RDs) and 95% confidence intervals (CIs) 
      for the associations between log-centered serum metal concentrations and prostate 
      cancer risk with adjustment for potential confounders. Bayesian kernel machine 
      regression (BKMR) models were used to account for nonlinear, interactive, and 
      joint metal effects. RESULTS: Using probit regression, four heavy metals (As, Zn, 
      Mn, Sb) were significantly and positively associated with prostate cancer risk in 
      the unadjusted models. Using BKMR analysis, both As and Zn had positive risk 
      differences on prostate cancer risk when all other metals were held fixed at the 
      25th and 50th percentiles (RD, 25th percentile: As: 0.15, Zn: 0.19, RD, 50th 
      percentile: As: 0.45, Zn: 0.37). In addition, the overall mixture risk difference 
      was positive and the 95% credible intervals did not include 0 when all metals in 
      the mixture were jointly above their 55th percentile, as compared to when all 
      metals were below their median values. CONCLUSIONS: In summary, we found positive 
      associations between the serum levels of As and Zn and prostate cancer risk on 
      the risk difference scale using BKMR models. The overall mixture effect was also 
      associated with increased prostate cancer risk. Future studies are warranted to 
      validate these findings in prospective studies.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Lim, Jue Tao
AU  - Lim JT
AD  - Saw Swee Hock School of Public Health, National University of Singapore, National 
      University Health System, Singapore.
FAU - Tan, Yue Qian
AU  - Tan YQ
AD  - Saw Swee Hock School of Public Health, National University of Singapore, National 
      University Health System, Singapore.
FAU - Valeri, Linda
AU  - Valeri L
AD  - Department of Biostatistics, Columbia University Mailman School of Public Health, 
      New York, NY, USA.
FAU - Lee, Jingyi
AU  - Lee J
AD  - NUS Environmental Research Institute, National University of Singapore, 
      Singapore.
FAU - Geok, Per Poh
AU  - Geok PP
AD  - NUS Environmental Research Institute, National University of Singapore, 
      Singapore.
FAU - Chia, Sin Eng
AU  - Chia SE
AD  - Saw Swee Hock School of Public Health, National University of Singapore, National 
      University Health System, Singapore; Department of Medicine, Yong Loo Lin School 
      of Medicine, National University of Singapore, National University Health System, 
      Singapore.
FAU - Ong, Choon Nam
AU  - Ong CN
AD  - Saw Swee Hock School of Public Health, National University of Singapore, National 
      University Health System, Singapore; NUS Environmental Research Institute, 
      National University of Singapore, Singapore.
FAU - Seow, Wei Jie
AU  - Seow WJ
AD  - Saw Swee Hock School of Public Health, National University of Singapore, National 
      University Health System, Singapore; Department of Medicine, Yong Loo Lin School 
      of Medicine, National University of Singapore, National University Health System, 
      Singapore. Electronic address: ephswj@nus.edu.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190903
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Metals, Heavy)
RN  - H6241UJ22B (Selenium)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Aged
MH  - Arsenic/*blood
MH  - Bayes Theorem
MH  - Biological Monitoring/statistics & numerical data
MH  - Humans
MH  - Male
MH  - Metals, Heavy/*blood
MH  - Middle Aged
MH  - Prostatic Neoplasms/*epidemiology
MH  - Risk Factors
MH  - Selenium/*blood
MH  - Singapore
OTO - NOTNLM
OT  - Combined effects
OT  - Heavy metals
OT  - Joint exposure
OT  - Mixtures
OT  - Prostate cancer
EDAT- 2019/09/07 06:00
MHDA- 2020/02/26 06:00
CRDT- 2019/09/07 06:00
PHST- 2019/04/03 00:00 [received]
PHST- 2019/07/30 00:00 [revised]
PHST- 2019/08/19 00:00 [accepted]
PHST- 2019/09/07 06:00 [pubmed]
PHST- 2020/02/26 06:00 [medline]
PHST- 2019/09/07 06:00 [entrez]
AID - S0160-4120(19)31095-5 [pii]
AID - 10.1016/j.envint.2019.105109 [doi]
PST - ppublish
SO  - Environ Int. 2019 Nov;132:105109. doi: 10.1016/j.envint.2019.105109. Epub 2019 
      Sep 3.