PMID- 31491814
OWN - NLM
STAT- MEDLINE
DCOM- 20200806
LR  - 20200806
IS  - 2213-1582 (Electronic)
IS  - 2213-1582 (Linking)
VI  - 23
DP  - 2019
TI  - Somatic symptoms disorders in Parkinson's disease are related to default mode and 
      salience network dysfunction.
PG  - 101932
LID - S2213-1582(19)30282-7 [pii]
LID - 10.1016/j.nicl.2019.101932 [doi]
LID - 101932
AB  - BACKGROUND: Somatic Symptoms Disorder (SSD) has been shown to have a clinically 
      very high prevalence in Parkinson's Disease (PD) with frequencies ranging from 
      7.0% to 66.7%, higher than in the general population (10%- 25%). SSD has been 
      associated with dysfunction in Default Mode and Salience network. AIM: With the 
      present study we aim to verify by means of resting state functional MRI whether 
      possible specific abnormalities in the activation and functional connectivity of 
      the default mode network (DMN) and salience network in cognitively intact PD 
      patients may be more prominent in PD patients with somatic symptoms (SSD-PD) as 
      compared with patients without SSD (PD). METHODS: Eighteen SSD-PD patients (61% 
      male), 18 PD patients (83% male) and 22 healthy age-matched subjects (59% male) 
      were enrolled in the study and underwent resting state functional MRI. RESULTS: 
      fractional amplitude of low-frequency fluctuation (fALFF) showed reduced activity 
      in bilateral lateral parietal cortex and in left anterior insula in both SSD-PD 
      and PD compared to control group. Functional connectivity (FC) values in the DMN 
      areas and between DMN and salience network areas were found to be lower in SSD-PD 
      than in control group and PD. No significant correlation was found between fMRI 
      results and demographic and clinical variables, excluding the effect of possible 
      confounders on fMRI results. The present study, showing reduced activity in 
      bilateral parietal areas and in the left anterior insula as compared to healthy 
      controls, suggests a dysfunction of the DMN and salience network in PD, either 
      with or without SSD. The FC reduction within DMN areas and between DMN and 
      salience network areas in SSD-PD patients suggests a role of dysfunctional 
      connectivity in the resting state network of patients with SSD.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Franciotti, Raffaella
AU  - Franciotti R
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. 
      d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Delli Pizzi, Stefano
AU  - Delli Pizzi S
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. 
      d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Russo, Mirella
AU  - Russo M
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. 
      d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Carrarini, Claudia
AU  - Carrarini C
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. 
      d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Carrozzino, Danilo
AU  - Carrozzino D
AD  - Department of Psychological Sciences, Health and Territorial Sciences, University 
      G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Perfetti, Bernardo
AU  - Perfetti B
AD  - Department of Psychological Sciences, Health and Territorial Sciences, University 
      G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Onofrj, Marco
AU  - Onofrj M
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. 
      d'Annunzio of Chieti-Pescara, Chieti, Italy.
FAU - Bonanni, Laura
AU  - Bonanni L
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. 
      d'Annunzio of Chieti-Pescara, Chieti, Italy. Electronic address: 
      l.bonanni@unich.it.
LA  - eng
PT  - Journal Article
DEP - 20190715
PL  - Netherlands
TA  - Neuroimage Clin
JT  - NeuroImage. Clinical
JID - 101597070
SB  - IM
MH  - Aged
MH  - Cerebral Cortex/diagnostic imaging/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Medically Unexplained Symptoms
MH  - Middle Aged
MH  - Nerve Net/diagnostic imaging/*physiopathology
MH  - Parkinson Disease/diagnostic imaging/*physiopathology
PMC - PMC6658828
OTO - NOTNLM
OT  - Default mode network
OT  - Fractional amplitude of low-frequency fluctuation
OT  - Parkinson's disease
OT  - Resting state functional MRI
OT  - Salience network
OT  - Somatic symptoms disorder
EDAT- 2019/09/08 06:00
MHDA- 2020/08/07 06:00
PMCR- 2019/07/15
CRDT- 2019/09/08 06:00
PHST- 2019/04/11 00:00 [received]
PHST- 2019/06/11 00:00 [revised]
PHST- 2019/07/13 00:00 [accepted]
PHST- 2019/09/08 06:00 [entrez]
PHST- 2019/09/08 06:00 [pubmed]
PHST- 2020/08/07 06:00 [medline]
PHST- 2019/07/15 00:00 [pmc-release]
AID - S2213-1582(19)30282-7 [pii]
AID - 101932 [pii]
AID - 10.1016/j.nicl.2019.101932 [doi]
PST - ppublish
SO  - Neuroimage Clin. 2019;23:101932. doi: 10.1016/j.nicl.2019.101932. Epub 2019 Jul 
      15.