PMID- 31493225
OWN - NLM
STAT- MEDLINE
DCOM- 20190918
LR  - 20190918
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1178
DP  - 2019
TI  - Dietary Restriction, Cardiovascular Aging and Age-Related Cardiovascular 
      Diseases: A Review of the Evidence.
PG  - 113-127
LID - 10.1007/978-3-030-25650-0_7 [doi]
AB  - Both morbidity and mortality due to cardiovascular diseases (CVDs) elevate with 
      age. The elevated prevalence of cardiovascular risk factors with age and 
      cardiovascular aging contribute to the relationship between aging and CVDs. 
      Dietary restriction (DR) consisting of calorie restriction (CR) and alternate-day 
      fasting (ADF) is an approved nutritional intervention and shows anti-aging 
      impacts. Recent studies demonstrate that DR makes an active defense response in 
      stressful states. At the core of this response are cardiovascular protective 
      signals, which consist of the mammalian target of rapamycin (mTOR), AMP-activated 
      kinase, sirtuins and endothelial nitric oxide synthase. These make a network with 
      positive and negative feedback regulation. Hence, DR is a hopeful intervention 
      for controlling cardiovascular aging and managing individuals with CVDs.
FAU - Abiri, Behnaz
AU  - Abiri B
AD  - Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
FAU - Vafa, Mohammadreza
AU  - Vafa M
AD  - Department of Nutrition, School of Public Health, Iran University of Medical 
      Sciences, Tehran, Iran. vafa.m@iums.ac.ir.
AD  - Pediatric Growth and Development Research Center, Institute of Endocrinology and 
      Metabolism, Iran University of Medical Sciences, Tehran, Iran. vafa.m@iums.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
SB  - IM
MH  - Aging/physiology
MH  - *Caloric Restriction
MH  - *Cardiovascular Diseases/diet therapy
MH  - *Fasting
MH  - Humans
OTO - NOTNLM
OT  - Age-related cardiovascular diseases
OT  - Alternate-day fasting
OT  - Animal models
OT  - Calorie restriction
OT  - Cardiovascular aging
OT  - Humans
EDAT- 2019/09/08 06:00
MHDA- 2019/09/19 06:00
CRDT- 2019/09/08 06:00
PHST- 2019/09/08 06:00 [entrez]
PHST- 2019/09/08 06:00 [pubmed]
PHST- 2019/09/19 06:00 [medline]
AID - 10.1007/978-3-030-25650-0_7 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2019;1178:113-127. doi: 10.1007/978-3-030-25650-0_7.