PMID- 31494415
OWN - NLM
STAT- MEDLINE
DCOM- 20191220
LR  - 20191220
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 698
DP  - 2020 Jan 1
TI  - Persistent organic pollutants in Greenlandic pregnant women and indices of foetal 
      growth: The ACCEPT study.
PG  - 134118
LID - S0048-9697(19)34095-1 [pii]
LID - 10.1016/j.scitotenv.2019.134118 [doi]
AB  - The Greenlandic population has some of the highest levels of environmental 
      persistent organic pollutants (POPs) globally. Studies have previously found POPs 
      to be linked with disturbance of child development, immune function and 
      reproductive abilities. We investigated the associations between serum POP levels 
      of pregnant women in Greenland and their infant's birth weight, length, head 
      circumference and gestational age (GA) at birth. Pregnant Greenlandic women 
      (n = 504) were enrolled during pregnancy and serum levels of the lipophilic POPs 
      (Organochlorine pesticides, Polychlorinated biphenyls and Polybrominated diphenyl 
      ethers) and the amphiphilic POPs, Perfluoroalkylated substances (PFASs), were 
      measured. We analysed the associations between maternal serum levels of POPs and 
      birth weight, length, head circumference and GA using linear regression analysis. 
      We found significant inverse associations between Perfluorooctanoic Acid (PFOA) 
      and birth weight (adjusted beta = -119 g, 95% CI: -201; -36), birth length (adjusted 
      beta = -0.37 cm, 95% CI: -0.76; 0.02, borderline significant) and head circumference 
      (adjusted beta = -0.35 cm, 95% CI: -0.59; -0.10) and a positive association with GA 
      (adjusted beta = 0.45 week, 95% CI: 0.17; 0.74). For the lipophilic POPs, we found 
      an overall trend of inverse associations to foetal growth indices. In conclusion, 
      we found that the amphiphilic PFOA had a significant inversely association with 
      foetal growth indices, whereas GA was positively associated. The data indicate 
      that POPs have a negative effect on foetal growth.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Hjermitslev, Marie Harthoj
AU  - Hjermitslev MH
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Denmark.
FAU - Long, Manhai
AU  - Long M
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Denmark.
FAU - Wielsoe, Maria
AU  - Wielsoe M
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Denmark.
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
AD  - Center for Arctic Health and Molecular Epidemiology, Department of Public Health, 
      Aarhus University, Denmark; Greenland Center for Health Research, University of 
      Greenland, Nuuk, Greenland. Electronic address: ebj@ph.au.dk.
LA  - eng
PT  - Journal Article
DEP - 20190827
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - *Fetal Development
MH  - Gestational Age
MH  - Greenland/epidemiology
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Maternal Exposure/*statistics & numerical data
MH  - Pesticides/blood
MH  - Polychlorinated Biphenyls/blood
MH  - Pregnancy
OTO - NOTNLM
OT  - Arctic
OT  - Birth outcome
OT  - Greenland
OT  - Lipophilic persistent organic pollutants
OT  - Perfluoroalkylated substances
OT  - Pregnant
EDAT- 2019/09/09 06:00
MHDA- 2019/12/21 06:00
CRDT- 2019/09/09 06:00
PHST- 2019/06/26 00:00 [received]
PHST- 2019/08/23 00:00 [revised]
PHST- 2019/08/25 00:00 [accepted]
PHST- 2019/09/09 06:00 [pubmed]
PHST- 2019/12/21 06:00 [medline]
PHST- 2019/09/09 06:00 [entrez]
AID - S0048-9697(19)34095-1 [pii]
AID - 10.1016/j.scitotenv.2019.134118 [doi]
PST - ppublish
SO  - Sci Total Environ. 2020 Jan 1;698:134118. doi: 10.1016/j.scitotenv.2019.134118. 
      Epub 2019 Aug 27.