PMID- 31496112
OWN - NLM
STAT- MEDLINE
DCOM- 20200525
LR  - 20200525
IS  - 1751-2980 (Electronic)
IS  - 1751-2972 (Linking)
VI  - 20
IP  - 11
DP  - 2019 Nov
TI  - HLA-DQ genotypes relative risks for celiac disease in Arabs: A case-control 
      study.
PG  - 602-608
LID - 10.1111/1751-2980.12817 [doi]
AB  - OBJECTIVES: It remains unknown what degree of risk is conferred by celiac disease 
      (CD)-predisposing human leukocyte antigen (HLA)-DQ genotypes in Saudi Arabia 
      compared with in Western countries. In this study, we aimed to determine the CD 
      risk gradient associated with the HLA-DQ genotypes and to compare HLA-DQ 
      genotypes between symptomatic patients with CD and screening-identified 
      asymptomatic CD patients. METHODS: We enrolled three groups of subjects, 
      including 46 CD children diagnosed consecutively over the past 10 years, 54 CD 
      children diagnosed during a mass screening of schoolchildren, and 192 healthy 
      controls. All the participants were typed for the HLA-DQA1 and HLA-DQB1 genes by 
      polymerase chain reaction sequence-specific oligonucleotide probes. RESULTS: 
      Comparing the patients with CD to controls, we identified 5 groups in the CD risk 
      gradient: (i) very high risk associated with the DQ2.5/DQ8 genotype (odds ratio 
      [OR] 46.93); (ii) high risk (homozygous DQ2.5, DQ2.5/DQ2.2; OR 4.12-5.04); (iii) 
      intermediate risk (heterozygous DQ2.5, DQ8/DQ2.2; OR 1.61 and 1.67); (iv) low 
      risk (DQ8, DQ2.2); and (v) very low risk (DQ2.x, DQX.5, DQX.x). Heterozygous DQ8 
      was more common in screening-identified group compared to symptomatic patients 
      (13.0% vs 2.2%); however, other genotypes were very similar between the two 
      groups. CONCLUSION: The highest risk of developing CD in our Saudi Arabia 
      population is associated with the DQ2.5/DQ8 genotype.
CI  - (c) 2019 Chinese Medical Association Shanghai Branch, Chinese Society of 
      Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University 
      School of Medicine and John Wiley & Sons Australia, Ltd.
FAU - Al-Hussaini, Abdulrahman
AU  - Al-Hussaini A
AUID- ORCID: 0000-0003-4512-9070
AD  - Division of Pediatric Gastroenterology, Children's Specialized Hospital, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
AD  - College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
FAU - Eltayeb-Elsheikh, Nezar
AU  - Eltayeb-Elsheikh N
AD  - Department of Pathology and Laboratory Medicine, Division of Immunology, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
FAU - Alharthi, Hanan
AU  - Alharthi H
AD  - Department of Pathology and Laboratory Medicine, Division of Immunology, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
FAU - Osman, Awad
AU  - Osman A
AD  - Department of Pathology and Laboratory Medicine, Division of Immunology, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
FAU - Alshahrani, Maram
AU  - Alshahrani M
AD  - Division of Pediatric Gastroenterology, Children's Specialized Hospital, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
FAU - Sandogji, Ibrahim
AU  - Sandogji I
AD  - Division of Pediatric Gastroenterology, Children's Specialized Hospital, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
FAU - Alrashidi, Sami
AU  - Alrashidi S
AD  - Division of Pediatric Gastroenterology, Children's Specialized Hospital, King 
      Fahad Medical City, Riyadh, Saudi Arabia.
FAU - Bashir, Muhammed Salman
AU  - Bashir MS
AD  - Department of Biostatistics, Research Services Administration, Research Center at 
      King Fahad Medical City, Riyadh, Saudi Arabia.
LA  - eng
GR  - A-T-32-48/King Abdulaziz City for Science and Technology/
PT  - Journal Article
DEP - 20191022
PL  - Australia
TA  - J Dig Dis
JT  - Journal of digestive diseases
JID - 101302699
RN  - 0 (HLA-DQ Antigens)
SB  - IM
MH  - Case-Control Studies
MH  - Celiac Disease/*etiology/genetics
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - Humans
MH  - Male
MH  - Risk
OTO - NOTNLM
OT  - DQ2.2
OT  - HLA typing
OT  - HLA-DQ2.5
OT  - HLA-DQ8
OT  - Saudi Arabia
OT  - celiac disease
EDAT- 2019/09/10 06:00
MHDA- 2020/05/26 06:00
CRDT- 2019/09/10 06:00
PHST- 2019/03/15 00:00 [received]
PHST- 2019/08/30 00:00 [revised]
PHST- 2019/09/04 00:00 [accepted]
PHST- 2019/09/10 06:00 [pubmed]
PHST- 2020/05/26 06:00 [medline]
PHST- 2019/09/10 06:00 [entrez]
AID - 10.1111/1751-2980.12817 [doi]
PST - ppublish
SO  - J Dig Dis. 2019 Nov;20(11):602-608. doi: 10.1111/1751-2980.12817. Epub 2019 Oct 
      22.