PMID- 31496775
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231013
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Urinary biomarkers for diagnosing poststroke depression in patients with type 2 
      diabetes mellitus.
PG  - 1379-1386
LID - 10.2147/DMSO.S215187 [doi]
AB  - BACKGROUND: Depression can seriously affect the quality of life of type 2 
      diabetes mellitus (T2DM) patients after stroke. However, there were still no 
      objective methods to diagnose T2DM patients with poststroke depression (PSD). 
      Therefore, we conducted this study to deal with this problem. METHODS: Gas 
      chromatography-mass spectroscopy (GC-MS)-based metabolomics profiling method was 
      used to profile the urinary metabolites from 83 nondepressed T2DM patients after 
      stroke and 101 T2DM patients with PSD. The orthogonal partial least-squares 
      discriminant analysis was conducted to explore the metabolic differences in T2DM 
      patients with PSD. The logistic regression analysis was performed to identify the 
      optimal and simplified biomarker panel for diagnosing T2DM patients with PSD. The 
      receiver operating characteristic curve analysis was used to assess the 
      diagnostic performance of this biomarker panel. RESULTS: In total, 23 
      differential metabolites (7 decreased and 16 increased in T2DM patients with PSD) 
      were found. A panel consisting of pseudouridine, malic acid, hypoxanthine, 
      3,4-dihydroxybutyric acid, fructose and inositol was identified. This panel could 
      effectively separate T2DM patients with PSD from nondepressed T2DM patients after 
      stroke. The area under the curve was 0.965 in the training set and 0.909 in the 
      validation set. Meanwhile, we found that the galactose metabolism was 
      significantly affected in T2DM patients with PSD. CONCLUSION: Our results could 
      be helpful for future development of an objective method to diagnose T2DM 
      patients with PSD and provide novel ideas to study the pathogenesis of 
      depression.
FAU - Liang, Zi-Hong
AU  - Liang ZH
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Jia, Yan-Bo
AU  - Jia YB
AD  - Department of Orthopaedics, The Second Affiliated Hospital of Inner Mongolia 
      Medical University, Huhhot, Inner Mongolia, People's Republic of China.
FAU - Li, Zi-Ru
AU  - Li ZR
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Li, Min
AU  - Li M
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Wang, Mei-Ling
AU  - Wang ML
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Yun, Yong-Li
AU  - Yun YL
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Yu, Li-Jun
AU  - Yu LJ
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Shi, Lei
AU  - Shi L
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
FAU - Zhu, Run-Xiu
AU  - Zhu RX
AD  - Department of Neurology, Inner Mongolia Autonomous Region People's Hospital, 
      Huhhot, Inner Mongolia, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20190813
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6698178
OTO - NOTNLM
OT  - metabolite
OT  - metabolomics
OT  - post-stroke depression
OT  - type 2 diabetes mellitus
COIS- The authors declare no financial or other conflicts of interest in this work.
EDAT- 2019/09/10 06:00
MHDA- 2019/09/10 06:01
PMCR- 2019/08/13
CRDT- 2019/09/10 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2019/07/04 00:00 [accepted]
PHST- 2019/09/10 06:00 [entrez]
PHST- 2019/09/10 06:00 [pubmed]
PHST- 2019/09/10 06:01 [medline]
PHST- 2019/08/13 00:00 [pmc-release]
AID - 215187 [pii]
AID - 10.2147/DMSO.S215187 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Aug 13;12:1379-1386. doi: 10.2147/DMSO.S215187. 
      eCollection 2019.