PMID- 31497235
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 11
IP  - 8
DP  - 2019
TI  - Resveratrol improves cardiac function by promoting M2-like polarization of 
      macrophages in mice with myocardial infarction.
PG  - 5212-5226
AB  - Macrophage polarization determines the transition from the inflammation phase to 
      the inflammation resolution phase after myocardial infarction (MI). The aim of 
      the present study was to investigate whether resveratrol (RSV) could inhibit the 
      inflammatory mediators associated with the regulation of macrophage phenotypes 
      and functions in MI mice. We initially discovered that RSV significantly improved 
      cardiac function and suppressed the expression of fibrosis markers, such as 
      collagen-I, collagen-III, and fibronectin, and pro-inflammatory cytokines, 
      including interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor 
      alpha (TNF-alpha). RSV inhibited the expression of M1-like macrophage-related 
      biomarkers (e.g., TNF-alpha and MCP-1) when bone marrow-derived macrophages (BMDMs) 
      were stimulated with lipopolysaccharide (LPS) and interferon-gamma (INF-gamma). In 
      contrast, it upregulated M2-like macrophage-related biomarkers (e.g., CD163 and 
      Arg-1) when BMDMs were stimulated with interleukin-4 (IL-4) and interleukin-10 
      (IL-10). In addition, we found that RSV promoted M2-like macrophage polarization 
      under anoxic conditions, which could be related to JAK2-SATA3 phosphorylation. In 
      summary, RSV might promote anti-inflammatory M2-like polarization of macrophages 
      after MI to improve cardiac function via the regulation of JAK2-SATA3 
      phosphorylation.
FAU - Liu, Shuiyuan
AU  - Liu S
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University Nanjing, Jiangsu, P. R. China.
FAU - Du, Yingqiang
AU  - Du Y
AD  - Department of Cardiology, The Affliated Suzhou Hospital of Nanjing Medical 
      University, Suzhou Municipal Hospital Suzhou, Jiangsu, P. R. China.
FAU - Shi, Kexin
AU  - Shi K
AD  - Department of Ultrasound, The First Affiliated Hospital of Nanjing Medical 
      University Nanjing, Jiangsu, P. R. China.
FAU - Yang, Yaqing
AU  - Yang Y
AD  - Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and 
      Molecular Intervention, Nanjing Medical University Nanjing, Jiangsu, P. R. China.
FAU - Yang, Zhijian
AU  - Yang Z
AD  - Department of Cardiology, The First Affiliated Hospital of Nanjing Medical 
      University Nanjing, Jiangsu, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20190815
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC6731431
OTO - NOTNLM
OT  - JAK2-SATA3 phosphorylation
OT  - Resveratrol
OT  - inflammation
OT  - macrophage polarization
OT  - myocardial infarction
COIS- None.
EDAT- 2019/09/10 06:00
MHDA- 2019/09/10 06:01
PMCR- 2019/08/15
CRDT- 2019/09/10 06:00
PHST- 2019/07/22 00:00 [received]
PHST- 2019/08/03 00:00 [accepted]
PHST- 2019/09/10 06:00 [entrez]
PHST- 2019/09/10 06:00 [pubmed]
PHST- 2019/09/10 06:01 [medline]
PHST- 2019/08/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2019 Aug 15;11(8):5212-5226. eCollection 2019.