PMID- 31498485
OWN - NLM
STAT- MEDLINE
DCOM- 20200914
LR  - 20200914
IS  - 1097-4644 (Electronic)
IS  - 0730-2312 (Linking)
VI  - 120
IP  - 12
DP  - 2019 Dec
TI  - miR-4735-3p regulates phenotypic modulation of vascular smooth muscle cells by 
      targeting HIF-1-mediated autophagy in intracranial aneurysm.
PG  - 19432-19441
LID - 10.1002/jcb.29219 [doi]
AB  - Intracranial aneurysm (IA) is recognized as a lethal form of cerebrovascular 
      disease mainly featured with a modulated phenotype of vascular smooth muscle 
      cells (SMCs). It is generally believed that enhanced SMC proliferation and 
      migration capabilities are the main characteristics in this process. In this 
      study, we revealed that microRNA-4735 (miR-4735) participates in phenotypic 
      modulation in a hypoxia-inducible factor-1 (HIF-1)-dependent manner of SMCs. 
      miR-4735 targets the 3'-untranslated region of HIF-1. The downregulated 
      expression of miR-4735 in IA tissues leads to elevated expression of HIF-1, which 
      activates autophagy and promotes autophagy-mediated SMC proliferation and 
      migration. Overexpression of miR-4735 suppressed HIF-1 expression and 
      HIF-1-mediated autophagy, which led to impaired SMC proliferation and migration 
      abilities. Forced expression of HIF-1 in miR-4735-overexpressed SMCs rescued the 
      impaired SMC proliferation and migration abilities. In conclusion, miR-4735 plays 
      an important role in phenotypic modulation in IA by regulating autophagy-promoted 
      SMC proliferation and migration.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Gao, Ge
AU  - Gao G
AUID- ORCID: 0000-0003-0332-8389
AD  - Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of 
      Life Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, P.R. China.
AD  - Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical 
      University, Hefei, Anhui, P.R. China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of 
      Life Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, P.R. China.
AD  - Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical 
      University, Hefei, Anhui, P.R. China.
FAU - Chao, Yingjiu
AU  - Chao Y
AD  - Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of 
      Life Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, P.R. China.
AD  - Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical 
      University, Hefei, Anhui, P.R. China.
FAU - Niu, Chaoshi
AU  - Niu C
AD  - Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of 
      Life Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, P.R. China.
AD  - Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical 
      University, Hefei, Anhui, P.R. China.
FAU - Fu, Xianming
AU  - Fu X
AD  - Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of 
      Life Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, P.R. China.
AD  - Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical 
      University, Hefei, Anhui, P.R. China.
FAU - Wei, Jianjun
AU  - Wei J
AD  - Department of Neurosurgery, The First Affiliated Hospital of USTC, Division of 
      Life Sciences and Medicine, University of Science and Technology of China, Hefei, 
      Anhui, P.R. China.
AD  - Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical 
      University, Hefei, Anhui, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20190909
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autophagy/genetics/*physiology
MH  - Blotting, Western
MH  - Cell Movement/genetics/physiology
MH  - Cell Proliferation/genetics/physiology
MH  - Cells, Cultured
MH  - Female
MH  - Humans
MH  - Hypoxia-Inducible Factor 1/genetics/*metabolism
MH  - Intracranial Aneurysm/genetics/*metabolism
MH  - Male
MH  - MicroRNAs/genetics/*metabolism
MH  - Middle Aged
MH  - Muscle, Smooth, Vascular/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - HIF-1
OT  - autophagy
OT  - intracranial aneurysm
OT  - miR-4735
OT  - phenotypic modulation
EDAT- 2019/09/10 06:00
MHDA- 2020/09/15 06:00
CRDT- 2019/09/10 06:00
PHST- 2018/09/14 00:00 [received]
PHST- 2019/05/20 00:00 [accepted]
PHST- 2019/09/10 06:00 [pubmed]
PHST- 2020/09/15 06:00 [medline]
PHST- 2019/09/10 06:00 [entrez]
AID - 10.1002/jcb.29219 [doi]
PST - ppublish
SO  - J Cell Biochem. 2019 Dec;120(12):19432-19441. doi: 10.1002/jcb.29219. Epub 2019 
      Sep 9.