PMID- 31500646
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20200225
IS  - 1550-2783 (Electronic)
IS  - 1550-2783 (Linking)
VI  - 16
IP  - 1
DP  - 2019 Sep 10
TI  - Effects of enzymatically modified isoquercitrin in supplementary protein powder 
      on athlete body composition: a randomized, placebo-controlled, double-blind 
      trial.
PG  - 39
LID - 10.1186/s12970-019-0303-x [doi]
LID - 39
AB  - BACKGROUND: Enzymatically modified isoquercitrin (EMIQ), a water-soluble 
      quercetin, has been shown to intensify muscle hypertrophy in mice. We 
      investigated the effect of EMIQ in supplementary protein powder on athlete body 
      composition. METHODS: Forty Japanese males who played American football (age: 
      19.8 +/- 1.4 years; body height: 174.1 +/- 6.0 cm; body mass: 75.5 +/- 10.7 kg) were 
      assigned to a randomized, placebo-controlled, double-blind trial of parallel 
      group. Participants received either EMIQ in whey protein (EW, n = 19) or contrast 
      whey protein (W, n = 20) 6 days per week over 4 months. Body composition was 
      assessed using dual-energy X-ray absorptiometry. Markers of oxidative stress, 
      derivatives of reactive oxygen metabolites (d-ROMs) and biological antioxidant 
      potential (BAP), were assessed using a free radical analytical system. Data were 
      analyzed using a univariate and repeated measures general model statistics. 
      RESULTS: After 4 months, changes in lower limb fat-free mass and muscle mass were 
      significantly greater in the EW group than in the W group (mean change +/-95% CI; 
      W: 324.1 +/- 284.3, EW: 950.3 +/- 473.2, p = 0.031, W: 255.7 +/- 288.6, EW: 
      930.9 +/- 471.5, p = 0.021, respectively). Moreover, the EW group exhibited a 
      significantly higher BAP/d-ROMs ratio, antioxidation index, than the W group 
      after 4 months (mean change +/- SD; W: 8.8 +/- 1.1, EW: 10.3 +/- 2.8; p = 0.028). No 
      significant differences in body mass, lean body mass, fat mass, or lower limb fat 
      mass were observed between the groups. CONCLUSION: Ingestion of EMIQ in 
      supplementary protein powder for 4 months exerts antioxidant effects and 
      increases muscle mass among American football players. TRIAL REGISTRATION: 
      University Hospital Medical Information Network Clinical Trial Registry, 
      UMIN000036036 . Retrospectively registered in 2019.
FAU - Omi, Naomi
AU  - Omi N
AD  - Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan. 
      ominaomi@taiiku.tsukuba.ac.jp.
AD  - Physical Education Graduate School, University of Tsukuba, Tsukuba, Japan. 
      ominaomi@taiiku.tsukuba.ac.jp.
FAU - Shiba, Hideki
AU  - Shiba H
AD  - Physical Education Graduate School, University of Tsukuba, Tsukuba, Japan.
FAU - Nishimura, Eisaku
AU  - Nishimura E
AD  - Health Science Research Center, Morinaga & Co., Ltd, Tokyo, Japan.
FAU - Tsukamoto, Sakuka
AU  - Tsukamoto S
AD  - Health Science Research Center, Morinaga & Co., Ltd, Tokyo, Japan.
FAU - Maruki-Uchida, Hiroko
AU  - Maruki-Uchida H
AD  - Health Science Research Center, Morinaga & Co., Ltd, Tokyo, Japan.
FAU - Oda, Masaya
AU  - Oda M
AD  - Physical Education Graduate School, University of Tsukuba, Tsukuba, Japan.
FAU - Morita, Minoru
AU  - Morita M
AD  - Health Science Research Center, Morinaga & Co., Ltd, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190910
PL  - United States
TA  - J Int Soc Sports Nutr
JT  - Journal of the International Society of Sports Nutrition
JID - 101234168
RN  - 0 (Dietary Proteins)
RN  - 0YX10VRV6J (isoquercitrin)
RN  - 9IKM0I5T1E (Quercetin)
SB  - IM
EIN - J Int Soc Sports Nutr. 2019 Oct 21;16(1):45. PMID: 31639004
MH  - Absorptiometry, Photon
MH  - Adolescent
MH  - Athletes
MH  - *Body Composition
MH  - Dietary Proteins/administration & dosage
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Football
MH  - Humans
MH  - Male
MH  - Muscle, Skeletal/*growth & development
MH  - Quercetin/administration & dosage/*analogs & derivatives
MH  - Sports Nutritional Physiological Phenomena
MH  - Young Adult
PMC - PMC6734270
OTO - NOTNLM
OT  - Antioxidant
OT  - Muscle mass
OT  - Quercetin
OT  - Resistance training
OT  - Rutin
OT  - Weight management
COIS- This research received financial support from MORINAGA & CO., Ltd. (Tokyo, 
      Japan). EN, ST, HM-U, and MM are employees of MORINAGA & CO., Ltd. The other 
      authors declare that they have no competing interests.
EDAT- 2019/09/11 06:00
MHDA- 2019/11/14 06:00
PMCR- 2019/09/10
CRDT- 2019/09/11 06:00
PHST- 2019/03/29 00:00 [received]
PHST- 2019/08/20 00:00 [accepted]
PHST- 2019/09/11 06:00 [entrez]
PHST- 2019/09/11 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
PHST- 2019/09/10 00:00 [pmc-release]
AID - 10.1186/s12970-019-0303-x [pii]
AID - 303 [pii]
AID - 10.1186/s12970-019-0303-x [doi]
PST - epublish
SO  - J Int Soc Sports Nutr. 2019 Sep 10;16(1):39. doi: 10.1186/s12970-019-0303-x.