PMID- 31505923
OWN - NLM
STAT- MEDLINE
DCOM- 20200218
LR  - 20200218
IS  - 1122-0643 (Print)
IS  - 1122-0643 (Linking)
VI  - 89
IP  - 3
DP  - 2019 Sep 10
TI  - Immune reconstitution inflammatory syndrome in tuberculous pleurisy and 
      ulcerative colitis: a case report.
LID - 10.4081/monaldi.2019.1103 [doi]
AB  - We present the case of a 46-year-old Caucasian male, affected by ulcerative 
      colitis, who developed tuberculous pleurisy during immunosuppressive therapy; 
      despite proper therapy, worsening of the radiological findings was observed. The 
      case was discussed among an online group of Italian physicians and diagnosis of 
      immune reconstitution inflammatory syndrome (IRIS) tuberculosis was established. 
      Therapy was continued and full recovery was obtained. IRIS is a syndrome 
      initially described during opportunistic infections in HIV infected after being 
      placed in anti-retroviral therapy. It reveals itself through a wide variety of 
      manifestations, including fever, lymphadenopathies, worsening of lung 
      infiltrates, pleural or pericardial effusion, central nervous system involvement. 
      Few data are available regarding the best therapeutic options. IRIS is an 
      insidious and potentially serious complication of opportunistic infections in 
      immunocompromised patients. The always wider diffusion of immunosuppressive 
      therapies increases the number of patients at risk, therefore physicians need to 
      be aware of the issue.
FAU - Piffer, Federico
AU  - Piffer F
AD  - Pulmonology Department, APSS Trento, Hospital of Arco. 
      federico.piffer@apss.tn.it.
FAU - Levi, Guido
AU  - Levi G
FAU - Marchetti, Giampietro
AU  - Marchetti G
FAU - Barbieri, Chiara
AU  - Barbieri C
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20190910
PL  - Italy
TA  - Monaldi Arch Chest Dis
JT  - Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
JID - 9307314
RN  - 0 (Antitubercular Agents)
RN  - 0 (Immunosuppressive Agents)
SB  - IM
MH  - Antitubercular Agents/therapeutic use
MH  - Colitis, Ulcerative/complications/*drug therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*chemically induced
MH  - Immunosuppressive Agents/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Opportunistic Infections/drug therapy/*etiology
MH  - Tuberculosis, Pleural/drug therapy/*etiology
EDAT- 2019/09/12 06:00
MHDA- 2020/02/19 06:00
CRDT- 2019/09/12 06:00
PHST- 2019/05/28 00:00 [received]
PHST- 2019/07/24 00:00 [accepted]
PHST- 2019/09/12 06:00 [entrez]
PHST- 2019/09/12 06:00 [pubmed]
PHST- 2020/02/19 06:00 [medline]
AID - 10.4081/monaldi.2019.1103 [doi]
PST - epublish
SO  - Monaldi Arch Chest Dis. 2019 Sep 10;89(3). doi: 10.4081/monaldi.2019.1103.